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African Trypanosomiasis

Updated : September 17, 2022





Background

Epidemiology

Anatomy

Pathophysiology

Etiology

Genetics

Prognostic Factors

Clinical History

Physical Examination

Age group

Associated comorbidity

Associated activity

Acuity of presentation

Differential Diagnoses

Laboratory Studies

Imaging Studies

Procedures

Histologic Findings

Staging

Treatment Paradigm

by Stage

by Modality

Chemotherapy

Radiation Therapy

Surgical Interventions

Hormone Therapy

Immunotherapy

Hyperthermia

Photodynamic Therapy

Stem Cell Transplant

Targeted Therapy

Palliative Care

Medication

 

melarsoprol 

Investigational Drug:


2 to 3.6mg/kg/day intravenous for three days
After one week, administer 3.6mg/kg/day intravenous for three days
Repetition after 10 to 21 days: 3.6 mg/kg per day



fexinidazole 

It is used for HAT hemolymphatic stage 1 and meningoencephalitic stage 2
10-Day treatment regimen
Days 1 to 4: 1800 mg (3 tab) orally every day, following
Days 5 to 10: 1200 mg (2 tab) orally every day



Dose Adjustments

Dosage Modifications
Hepatic impairment

pharmacokinetics not known; Contraindicated
Renal impairment
Mild-moderate (eGFR 30 to less than 89 mL/min/1.73 m2): dose adjustment is not required
Severe (eGFR less than 30 mL/min/1.73 m2): Pharmacokinetics are not known; avoid usage

 

melarsoprol 

Investigational Drug:


A dose of 18-25 mg/kg is administered once a month
Initial dose: 0.36mg/kg intravenously
Gradually increase to 3.6 mg/kg IV at 1-5 days intervals for a total of 9-10 doses



fexinidazole 

It is used for HAT hemolymphatic stage 1 and meningoencephalitic stage 2 in children aged above 6 years who weight 20 kg
Below 6 years: Safety & efficacy were not established
Above 6 years
10-Day treatment regimen
Above 20 to less than 35 kg
Days 1 to 4: 1200 mg (2 tab) orally every day, following
Days 5 to 10: 600 mg (1 tab) orally every day
More than 35 kg
Days 1 to 4: 1800 mg (3 tab) orally every day, following
Days 5 to 10: 1200 mg (2 tab) orally every day



Dose Adjustments

Dosage Modifications
Hepatic impairment

pharmacokinetics not known; Contraindicated
Renal impairment
Mild-moderate (eGFR 30 to less than 89 mL/min/1.73 m2): dose adjustment is not required
Severe (eGFR less than 30 mL/min/1.73 m2): Pharmacokinetics are not known; avoid usage

 

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References

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African Trypanosomiasis

Updated : September 17, 2022




melarsoprol 

Investigational Drug:


2 to 3.6mg/kg/day intravenous for three days
After one week, administer 3.6mg/kg/day intravenous for three days
Repetition after 10 to 21 days: 3.6 mg/kg per day



fexinidazole 

It is used for HAT hemolymphatic stage 1 and meningoencephalitic stage 2
10-Day treatment regimen
Days 1 to 4: 1800 mg (3 tab) orally every day, following
Days 5 to 10: 1200 mg (2 tab) orally every day



Dose Adjustments

Dosage Modifications
Hepatic impairment

pharmacokinetics not known; Contraindicated
Renal impairment
Mild-moderate (eGFR 30 to less than 89 mL/min/1.73 m2): dose adjustment is not required
Severe (eGFR less than 30 mL/min/1.73 m2): Pharmacokinetics are not known; avoid usage

melarsoprol 

Investigational Drug:


A dose of 18-25 mg/kg is administered once a month
Initial dose: 0.36mg/kg intravenously
Gradually increase to 3.6 mg/kg IV at 1-5 days intervals for a total of 9-10 doses



fexinidazole 

It is used for HAT hemolymphatic stage 1 and meningoencephalitic stage 2 in children aged above 6 years who weight 20 kg
Below 6 years: Safety & efficacy were not established
Above 6 years
10-Day treatment regimen
Above 20 to less than 35 kg
Days 1 to 4: 1200 mg (2 tab) orally every day, following
Days 5 to 10: 600 mg (1 tab) orally every day
More than 35 kg
Days 1 to 4: 1800 mg (3 tab) orally every day, following
Days 5 to 10: 1200 mg (2 tab) orally every day



Dose Adjustments

Dosage Modifications
Hepatic impairment

pharmacokinetics not known; Contraindicated
Renal impairment
Mild-moderate (eGFR 30 to less than 89 mL/min/1.73 m2): dose adjustment is not required
Severe (eGFR less than 30 mL/min/1.73 m2): Pharmacokinetics are not known; avoid usage

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