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B-Cell lymphoma

Updated : April 26, 2022



Background

Epidemiology

Anatomy

Pathophysiology

Etiology

Genetics

Prognostic Factors

Clinical History

Physical Examination

Age group

Associated comorbidity

Associated activity

Acuity of presentation

Differential Diagnoses

Laboratory Studies

Imaging Studies

Procedures

Histologic Findings

Staging

Treatment Paradigm

by Stage

by Modality

Chemotherapy

Radiation Therapy

Surgical Interventions

Hormone Therapy

Immunotherapy

Hyperthermia

Photodynamic Therapy

Stem Cell Transplant

Targeted Therapy

Palliative Care

Medication

 

epcoritamab 

Each cycle is 28 days
(Cycle 1)
At the beginning of the treatment, a step-up dose of 0.16 mg administered subcutaneously (SC) was given on the first day
On the eighth day, another step-up dose of 0.8 mg SC was given as a single dose
On the fifteenth day, the patient received a full dose of 48 mg SC in a single administration, requiring hospitalization for 24 hours during the initial 48-mg dose
On the twenty-second day, a single dose of 48 mg SC was administered (Cycles 2 & 3)
Administer a single subcutaneous dose of 48 mg on days 1, 8, 15, and 22 (Cycles 4 to 9)
On Days 1 and 15, a single dose of 48 mg should be administered subcutaneously
(Cycle 10 & after that)
On the first day, administer a single subcutaneous dose of 48 mg



glofitamab 


Indicated for B-Cell Lymphoma
Step up dose regimen:
Dosing starts with step up dose regimen, administer premedication for every dose
1-Cycle:
Day-1: After completion of the obinutuzumab dose, administer glofitamab as intravenous infusion
Day-8: glofitamab 2.5 mg intravenous over 4 hours for one time (step up dose-1)
Day-15: glofitamab 10 mg intravenous over 4 hours for one time (step up dose-2)
If a patient ever experienced CRS with an earlier dose, prolong the infusion rate for over 8 hours
2-Cycle:
Day-1: glofitamab 30 mg intravenous over 4 hours
If a patient ever experienced CRS with an earlier dose, prolong the infusion rate for over 8 hours
3-12 Cycle:
Day-1: glofitamab 30 mg intravenous over 4 hours
If a patient ever experienced CRS with an earlier dose, maintain the time of infusion at 4 hours
Continue the therapy for a maximum of 12 cycles, which includes the initial step-up dosing in 1-Cycle; or until there is disease progression or if unacceptable toxicity arises, whichever comes first



immune globulin IV (IGIV) 

400

mg/kg/dose

Intravenous (IV)

daily

3 - 4

weeks



 

immune globulin IV (IGIV) 

same as adult dosing



 

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B-Cell lymphoma

Updated : April 26, 2022


epcoritamab 

Each cycle is 28 days
(Cycle 1)
At the beginning of the treatment, a step-up dose of 0.16 mg administered subcutaneously (SC) was given on the first day
On the eighth day, another step-up dose of 0.8 mg SC was given as a single dose
On the fifteenth day, the patient received a full dose of 48 mg SC in a single administration, requiring hospitalization for 24 hours during the initial 48-mg dose
On the twenty-second day, a single dose of 48 mg SC was administered (Cycles 2 & 3)
Administer a single subcutaneous dose of 48 mg on days 1, 8, 15, and 22 (Cycles 4 to 9)
On Days 1 and 15, a single dose of 48 mg should be administered subcutaneously
(Cycle 10 & after that)
On the first day, administer a single subcutaneous dose of 48 mg



glofitamab 


Indicated for B-Cell Lymphoma
Step up dose regimen:
Dosing starts with step up dose regimen, administer premedication for every dose
1-Cycle:
Day-1: After completion of the obinutuzumab dose, administer glofitamab as intravenous infusion
Day-8: glofitamab 2.5 mg intravenous over 4 hours for one time (step up dose-1)
Day-15: glofitamab 10 mg intravenous over 4 hours for one time (step up dose-2)
If a patient ever experienced CRS with an earlier dose, prolong the infusion rate for over 8 hours
2-Cycle:
Day-1: glofitamab 30 mg intravenous over 4 hours
If a patient ever experienced CRS with an earlier dose, prolong the infusion rate for over 8 hours
3-12 Cycle:
Day-1: glofitamab 30 mg intravenous over 4 hours
If a patient ever experienced CRS with an earlier dose, maintain the time of infusion at 4 hours
Continue the therapy for a maximum of 12 cycles, which includes the initial step-up dosing in 1-Cycle; or until there is disease progression or if unacceptable toxicity arises, whichever comes first



immune globulin IV (IGIV) 

400

mg/kg/dose

Intravenous (IV)

daily

3 - 4

weeks



immune globulin IV (IGIV) 

same as adult dosing



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Founded in 2014, medtigo is committed to providing high-quality, friendly physicians, transparent pricing, and a focus on building relationships and a lifestyle brand for medical professionals nationwide.

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CONTACT INFORMATION

ADDRESS

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60 Roberts Drive, Suite 313,
North Adams, MA 01247

MAHARASHTRA – INDIA

7, Shree Krishna, 2nd Floor,
Opp Kiosk Koffee,
Shirole Lane, Off FC Road,
Pune 411004, Maharashtra

 

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