The symptoms of chromoblastomycosis are slow-growing, cauliflower-like lesions that could ulcerate, and these lesions are caused by a variety of brown pigment-producing dematiaceous fungi. The fungi develop solitary or multicellular clusters with thick walls.
These fungi find their way into the body through trauma, and lesions are consequently more prevalent on exposed body parts. The condition is chronic, but the vast majority of cases are curable.
Epidemiology
The regions most affected by this condition are the tropics and the subtropics. Individuals working in the agricultural field have a greater tendency to be affected, especially males.
Although rarer, children are also affected by chromoblastomycosis. Most of the world has reported cases of this disease, including Madagascar, Northern Europe, North, Central and South America, Jamaica, Cuba, and Australia.
Anatomy
Pathophysiology
After the skin suffers trauma, the fungi find their way into the skin and evoke a granulomatous response. Following this, the epidermis displays pseudoepitheliomatous hyperplasia, and a granuloma made of Langerhans giant cells and epithelioid cells is seen in the dermis.
The final elements can be seen as sclerotic bodies. As chromoblastomycosis manifests itself, black dots are seen on the surface of the lesion; they are extruded transepidermally.
Etiology
Numerous fungi are capable of causing the sickness. They are dematiaceous, meaning that they produce brown pigment.
Some of the most prevalent fungi which cause this disease include:
Phialophora verrucosa
Fonsecea pedrosoi
Cladosporium carrionii
Other fungi which are slightly less common are:
Exophialia spinier
Fonsacea compactum
Wangiella dermatitidis
Exophialia jeanselmei
Rhinocladiella aquaspersa
As a result of trauma, the fungi enter the body from wood and dirt. This illness is prevalent in rural areas. Cladosporium carrionii reproduces via fission.
It generates numerous conidia in long, straight chains that emerge from the hyphae, with the youngest conidia located furthest from the hyphae.
Genetics
Prognostic Factors
Chromoblastomycosis can be be completely cured through effective treatment. If it’s detected in the early stages, the prognosis is generally favourable, and there is a smaller chance of long-lasting symptoms.
Cases which have spread to the joints and are involved with the lymphatic system have a high chance of morbidity.
Once the illness has spread to the CNS, the prognosis is highly unfavorable. Individuals who have small lesions have a swift recovery after surgery, followed by anti-fungal therapy.
Clinical History
Physical Examination
Age group
Associated comorbidity
Associated activity
Acuity of presentation
Differential Diagnoses
Laboratory Studies
Imaging Studies
Procedures
Histologic Findings
Staging
Treatment Paradigm
by Stage
by Modality
Chemotherapy
Radiation Therapy
Surgical Interventions
Hormone Therapy
Immunotherapy
Hyperthermia
Photodynamic Therapy
Stem Cell Transplant
Targeted Therapy
Palliative Care
Medication
Future Trends
Media Gallary
References
https://www.ncbi.nlm.nih.gov/books/NBK470253/
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The symptoms of chromoblastomycosis are slow-growing, cauliflower-like lesions that could ulcerate, and these lesions are caused by a variety of brown pigment-producing dematiaceous fungi. The fungi develop solitary or multicellular clusters with thick walls.
These fungi find their way into the body through trauma, and lesions are consequently more prevalent on exposed body parts. The condition is chronic, but the vast majority of cases are curable.
The regions most affected by this condition are the tropics and the subtropics. Individuals working in the agricultural field have a greater tendency to be affected, especially males.
Although rarer, children are also affected by chromoblastomycosis. Most of the world has reported cases of this disease, including Madagascar, Northern Europe, North, Central and South America, Jamaica, Cuba, and Australia.
After the skin suffers trauma, the fungi find their way into the skin and evoke a granulomatous response. Following this, the epidermis displays pseudoepitheliomatous hyperplasia, and a granuloma made of Langerhans giant cells and epithelioid cells is seen in the dermis.
The final elements can be seen as sclerotic bodies. As chromoblastomycosis manifests itself, black dots are seen on the surface of the lesion; they are extruded transepidermally.
Numerous fungi are capable of causing the sickness. They are dematiaceous, meaning that they produce brown pigment.
Some of the most prevalent fungi which cause this disease include:
Phialophora verrucosa
Fonsecea pedrosoi
Cladosporium carrionii
Other fungi which are slightly less common are:
Exophialia spinier
Fonsacea compactum
Wangiella dermatitidis
Exophialia jeanselmei
Rhinocladiella aquaspersa
As a result of trauma, the fungi enter the body from wood and dirt. This illness is prevalent in rural areas. Cladosporium carrionii reproduces via fission.
It generates numerous conidia in long, straight chains that emerge from the hyphae, with the youngest conidia located furthest from the hyphae.
Chromoblastomycosis can be be completely cured through effective treatment. If it’s detected in the early stages, the prognosis is generally favourable, and there is a smaller chance of long-lasting symptoms.
Cases which have spread to the joints and are involved with the lymphatic system have a high chance of morbidity.
Once the illness has spread to the CNS, the prognosis is highly unfavorable. Individuals who have small lesions have a swift recovery after surgery, followed by anti-fungal therapy.
https://www.ncbi.nlm.nih.gov/books/NBK470253/
medtigo
Chromoblastomycosis
Updated :
June 22, 2022
The symptoms of chromoblastomycosis are slow-growing, cauliflower-like lesions that could ulcerate, and these lesions are caused by a variety of brown pigment-producing dematiaceous fungi. The fungi develop solitary or multicellular clusters with thick walls.
These fungi find their way into the body through trauma, and lesions are consequently more prevalent on exposed body parts. The condition is chronic, but the vast majority of cases are curable.
The regions most affected by this condition are the tropics and the subtropics. Individuals working in the agricultural field have a greater tendency to be affected, especially males.
Although rarer, children are also affected by chromoblastomycosis. Most of the world has reported cases of this disease, including Madagascar, Northern Europe, North, Central and South America, Jamaica, Cuba, and Australia.
After the skin suffers trauma, the fungi find their way into the skin and evoke a granulomatous response. Following this, the epidermis displays pseudoepitheliomatous hyperplasia, and a granuloma made of Langerhans giant cells and epithelioid cells is seen in the dermis.
The final elements can be seen as sclerotic bodies. As chromoblastomycosis manifests itself, black dots are seen on the surface of the lesion; they are extruded transepidermally.
Numerous fungi are capable of causing the sickness. They are dematiaceous, meaning that they produce brown pigment.
Some of the most prevalent fungi which cause this disease include:
Phialophora verrucosa
Fonsecea pedrosoi
Cladosporium carrionii
Other fungi which are slightly less common are:
Exophialia spinier
Fonsacea compactum
Wangiella dermatitidis
Exophialia jeanselmei
Rhinocladiella aquaspersa
As a result of trauma, the fungi enter the body from wood and dirt. This illness is prevalent in rural areas. Cladosporium carrionii reproduces via fission.
It generates numerous conidia in long, straight chains that emerge from the hyphae, with the youngest conidia located furthest from the hyphae.
Chromoblastomycosis can be be completely cured through effective treatment. If it’s detected in the early stages, the prognosis is generally favourable, and there is a smaller chance of long-lasting symptoms.
Cases which have spread to the joints and are involved with the lymphatic system have a high chance of morbidity.
Once the illness has spread to the CNS, the prognosis is highly unfavorable. Individuals who have small lesions have a swift recovery after surgery, followed by anti-fungal therapy.
https://www.ncbi.nlm.nih.gov/books/NBK470253/
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