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Background
Epidemiology
Anatomy
Pathophysiology
Etiology
Genetics
Prognostic Factors
Clinical History
Physical Examination
Age group
Associated comorbidity
Associated activity
Acuity of presentation
Differential Diagnoses
Laboratory Studies
Imaging Studies
Procedures
Histologic Findings
Staging
Treatment Paradigm
by Stage
by Modality
Chemotherapy
Radiation Therapy
Surgical Interventions
Hormone Therapy
Immunotherapy
Hyperthermia
Photodynamic Therapy
Stem Cell Transplant
Targeted Therapy
Palliative Care
Medication
1 g IM or IV given every 12hrs for mild conditions
1-2 g IM or IV every 8hrs moderate to severe infections
2 g IV every 6-8hrs high dosing for infections
2 g IV every 4hrs for life-threatening infections
12 g is the maximum dose required per day
1-2 g IV or IM every 12hrs for moderate infections
2 g IV every 12hrs for Severe infections
3 g IV every 12hrs for Life-threatening infections
The maximum duration of therapy is seven days
Loading Dose: 200 mg via IV infusion for 1 hour on day 1 or 100 mg via IV infusion for 30mins two times on day 1 or 300 mg orally two times on day 1
Maintenance Dose: 100 mg via IV infusion for 30mins per day or 300 mg orally per day
the maximum duration of treatment is 7-14 days
500
mg
Tablet
Orally
every 8 hrs
5
days
Extend the therapy duration as per vital signs
1-2 g IV or IM was given once a day or in equally divided doses 2x a day
maximum duration of therapy is 4-14 days
prolonged treatment recommends for complicated infections
At least treatment given ten days for diseases due to streptococcus
800
mg
Orally
once a day
7 - 10
days
200
mg
Orally
every 12 hrs
14
days
Note: It is indicated for Acute Community-Acquired Pneumonia.
Indicated for Community Acquired Bacterial Pneumonia (CABP)
150 mg IV 2 times a day for 5-7 days
or
600 mg orally 2 times a day for 5 days
500 mg oral tablet immediate release twice a day for a minimum of 5 days
The drug treats pneumonia acquired due to various bacterial infections
500 mg orally once a day, followed by 250 mg 4 times a day, on the 2nd to 5th day
600 mg oral/IV 2 times daily 10-14 days
400
mg
Tablet
Intravenous (IV)
every day
7 - 14
days
(M. pneumoniae; S. pneumoniae; C. pneumoniae; H. influenzae): 320mg orally every day for five days
(Multidrug-resistant K. pneumoniae; S. pneumoniae; M. catarrhalis): 320mg orally every day for 7 days
1-2g intramuscular or intravenous every 8 to 12 hours
Do not exceed 8g/day
Day 1: 500 mg orally in a single dosage;
Days 2–5: 250 mg orally per day
(Off Label):
Fluoroquinolone and 500 mg intravenously every 8 hours for around five days
Take 400 mg orally after every 12 hours up to 14 days.
Take 200 mg orally after every 12 hours up to 10 days
Renal Impairment
For creatinine clearance of 30 to 49 ml/minute/1.73 square meter: maximum up to 200 mg orally after every 12 hours
For creatinine clearance of <30 ml/minute/1.73/square meter: every day 200 mg orally
End-stage: dose not determined yet
600
mg
Intravenous (IV)
twice a day
5 - 14
days
Pending for FDA approval
1 to 2 grams intravenous/intramuscular given every 2 times a day
300 mg in single dose or two divided doses every day
Administer dose of 500 mg intramuscularly or intravenously every 6 hours
100 to 300 mg orally daily, as a single or two divided doses
Dose Adjustments
Dosing modifications
Renal impairment:
Dose adjustment is required in case of severe impairment
600 mg oral/IV 2 times daily 10-14 days
≤7 days:
<2kg bodyweight: 30mg/kg intravenous every 12 hours
>2 kg bodyweight: 30mg/kg intravenous every 8 hours
8 to 30 days:
<1.2kg: 30mg/kg intravenous every 12 hours
1.2kg-2kg: 30mg/kg intravenous every 8 hours
>2kg: 30mg/kg intravenous every 6 hours
1 to 18 years: 30mg/kg intravenous every 6-8 hours
For <6 months: Safety and efficacy are not seen
For ≥6 months: 10 mg/kg orally as 1st dose on 1st day, followed by 5 mg/kg orally on 2nd to 5th day
Indicated for mild to severe infections:
>3 months:
150mg/kg/day intravenous/intramuscular divided every 8 hours
6 months: Safety and effectiveness are not yet proven
For six months, administer 10 mg/kg orally x 1 dosage on Day 1 and then 5 mg/kg orally on Days 2–5.
Children >8 years and adolescents:
1 to 2 mg/kg per dose twice a day for 10 days
Age: 2 months-<2 years:
8
mg/kg
Intravenous (IV)
every 8 hrs
5 - 14
days
Age: ≥2 years-<18 years; wt: ≤33 kg: 12 mg/kg Intravenous (IV) every 8 hrs 5-14 days
Age: 2-18 years; wt: >33 kg: 400 mg Intravenous (IV) every 8 hrs OR 600 mg Intravenous (IV) every 8 hrs 5-14 days
Age: ≥18 years: 600 mg Intravenous (IV) every 8 hrs 5-7 days
Pending for FDA approval
Children up to 12 years: 5 to 8 mg/kg in two divided doses every day; maximum dose: 150 mg 2 times a day
for infants and Children:
Administer daily dose of 50 to 100 mg/kg intramuscularly or intravenously divided doses every 4 to 8 hours
Future Trends
References
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1 g IM or IV given every 12hrs for mild conditions
1-2 g IM or IV every 8hrs moderate to severe infections
2 g IV every 6-8hrs high dosing for infections
2 g IV every 4hrs for life-threatening infections
12 g is the maximum dose required per day
1-2 g IV or IM every 12hrs for moderate infections
2 g IV every 12hrs for Severe infections
3 g IV every 12hrs for Life-threatening infections
The maximum duration of therapy is seven days
Loading Dose: 200 mg via IV infusion for 1 hour on day 1 or 100 mg via IV infusion for 30mins two times on day 1 or 300 mg orally two times on day 1
Maintenance Dose: 100 mg via IV infusion for 30mins per day or 300 mg orally per day
the maximum duration of treatment is 7-14 days
500
mg
Tablet
Orally
every 8 hrs
5
days
Extend the therapy duration as per vital signs
1-2 g IV or IM was given once a day or in equally divided doses 2x a day
maximum duration of therapy is 4-14 days
prolonged treatment recommends for complicated infections
At least treatment given ten days for diseases due to streptococcus
800
mg
Orally
once a day
7 - 10
days
200
mg
Orally
every 12 hrs
14
days
Note: It is indicated for Acute Community-Acquired Pneumonia.
Indicated for Community Acquired Bacterial Pneumonia (CABP)
150 mg IV 2 times a day for 5-7 days
or
600 mg orally 2 times a day for 5 days
500 mg oral tablet immediate release twice a day for a minimum of 5 days
The drug treats pneumonia acquired due to various bacterial infections
500 mg orally once a day, followed by 250 mg 4 times a day, on the 2nd to 5th day
600 mg oral/IV 2 times daily 10-14 days
400
mg
Tablet
Intravenous (IV)
every day
7 - 14
days
(M. pneumoniae; S. pneumoniae; C. pneumoniae; H. influenzae): 320mg orally every day for five days
(Multidrug-resistant K. pneumoniae; S. pneumoniae; M. catarrhalis): 320mg orally every day for 7 days
1-2g intramuscular or intravenous every 8 to 12 hours
Do not exceed 8g/day
Day 1: 500 mg orally in a single dosage;
Days 2–5: 250 mg orally per day
(Off Label):
Fluoroquinolone and 500 mg intravenously every 8 hours for around five days
Take 400 mg orally after every 12 hours up to 14 days.
Take 200 mg orally after every 12 hours up to 10 days
Renal Impairment
For creatinine clearance of 30 to 49 ml/minute/1.73 square meter: maximum up to 200 mg orally after every 12 hours
For creatinine clearance of <30 ml/minute/1.73/square meter: every day 200 mg orally
End-stage: dose not determined yet
600
mg
Intravenous (IV)
twice a day
5 - 14
days
Pending for FDA approval
1 to 2 grams intravenous/intramuscular given every 2 times a day
300 mg in single dose or two divided doses every day
Administer dose of 500 mg intramuscularly or intravenously every 6 hours
100 to 300 mg orally daily, as a single or two divided doses
Dose Adjustments
Dosing modifications
Renal impairment:
Dose adjustment is required in case of severe impairment
600 mg oral/IV 2 times daily 10-14 days
≤7 days:
<2kg bodyweight: 30mg/kg intravenous every 12 hours
>2 kg bodyweight: 30mg/kg intravenous every 8 hours
8 to 30 days:
<1.2kg: 30mg/kg intravenous every 12 hours
1.2kg-2kg: 30mg/kg intravenous every 8 hours
>2kg: 30mg/kg intravenous every 6 hours
1 to 18 years: 30mg/kg intravenous every 6-8 hours
For <6 months: Safety and efficacy are not seen
For ≥6 months: 10 mg/kg orally as 1st dose on 1st day, followed by 5 mg/kg orally on 2nd to 5th day
Indicated for mild to severe infections:
>3 months:
150mg/kg/day intravenous/intramuscular divided every 8 hours
6 months: Safety and effectiveness are not yet proven
For six months, administer 10 mg/kg orally x 1 dosage on Day 1 and then 5 mg/kg orally on Days 2–5.
Children >8 years and adolescents:
1 to 2 mg/kg per dose twice a day for 10 days
Age: 2 months-<2 years:
8
mg/kg
Intravenous (IV)
every 8 hrs
5 - 14
days
Age: ≥2 years-<18 years; wt: ≤33 kg: 12 mg/kg Intravenous (IV) every 8 hrs 5-14 days
Age: 2-18 years; wt: >33 kg: 400 mg Intravenous (IV) every 8 hrs OR 600 mg Intravenous (IV) every 8 hrs 5-14 days
Age: ≥18 years: 600 mg Intravenous (IV) every 8 hrs 5-7 days
Pending for FDA approval
Children up to 12 years: 5 to 8 mg/kg in two divided doses every day; maximum dose: 150 mg 2 times a day
for infants and Children:
Administer daily dose of 50 to 100 mg/kg intramuscularly or intravenously divided doses every 4 to 8 hours
Pending for FDA approval
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Founded in 2014, medtigo is committed to providing high-quality, friendly physicians, transparent pricing, and a focus on building relationships and a lifestyle brand for medical professionals nationwide.
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Pune 411004, Maharashtra
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