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Endometrial Carcinoma

Updated : April 26, 2022



Background

Epidemiology

Anatomy

Pathophysiology

Etiology

Genetics

Prognostic Factors

Clinical History

Physical Examination

Age group

Associated comorbidity

Associated activity

Acuity of presentation

Differential Diagnoses

Laboratory Studies

Imaging Studies

Procedures

Histologic Findings

Staging

Treatment Paradigm

by Stage

by Modality

Chemotherapy

Radiation Therapy

Surgical Interventions

Hormone Therapy

Immunotherapy

Hyperthermia

Photodynamic Therapy

Stem Cell Transplant

Targeted Therapy

Palliative Care

Medication

 

anastrozole

1

mg

Orally 

once a day

depending upon symptoms



goserelin

3.6 mg subcutaneously placed in the upper abdominal wall for every 28days The maximum duration of the treatment is six months



lenvatinib

20

mg

Orally 

4 times a day

It is given in combination with 200 mg of intravenous pembrolizumab every 3 weeks



trastuzumab

Advanced cancer:
:

Initial dose for cycle 1: 8 mg/kg IV over 90 mins
Maintenance dose: 6 mg/kg IV infused over 30 to 90 minutes every 3 Weeks in combination with carboplatin and paclitaxel for 6 cycles
Gastric metastatic cancer:
Initial dose for cycle 1: 8 mg/kg IV over 90 mins
Maintenance dose: 6 mg/kg IV infused over 30 to 90 minutes every 3 Weeks in combination with cisplatin and capecitabine/fluorouracil for 6 cycles



danazol 

Mild condition: 200-400 mg/day orally divided twice daily
Moderate to severe condition: 800 mg/day orally divided twice daily
Decrease the dose accordingly to sustain amenorrhea
Continue the therapy ranging from 6-9 months



megestrol 

Indicated for reducing the pain and symptoms due to advanced endometrial carcinoma
40-320 mg orally each day in divided doses
Check on the efficacy 2 months post-treatment
A maximum dose of up to 800 mg/day can be utilized
It shouldn’t be used as a substitute for radiotherapy, chemotherapy, or surgery



medroxyprogesterone 

Indicated for Metastatic Endometrial Carcinoma
Depo-Provera is only indicated for relieving the symptoms of recurrent, metastatic, or inoperable endometrial carcinoma
Initially 400-1000 mg intramuscularly each week



dostarlimab 

For the Initial dose
Dose 1 to Dose 4-Intravenous infusion of 500 mg for 30 minutes, repeated every three weeks
For the Maintenance dose
Starting from 3 weeks after Dose 4 (Dose 5 onwards)- Intravenous infusion of 1000 mg for 30 minutes, given for six weeks



 
 

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Endometrial Carcinoma

Updated : April 26, 2022


anastrozole

1

mg

Orally 

once a day

depending upon symptoms



goserelin

3.6 mg subcutaneously placed in the upper abdominal wall for every 28days The maximum duration of the treatment is six months



lenvatinib

20

mg

Orally 

4 times a day

It is given in combination with 200 mg of intravenous pembrolizumab every 3 weeks



trastuzumab

Advanced cancer:
:

Initial dose for cycle 1: 8 mg/kg IV over 90 mins
Maintenance dose: 6 mg/kg IV infused over 30 to 90 minutes every 3 Weeks in combination with carboplatin and paclitaxel for 6 cycles
Gastric metastatic cancer:
Initial dose for cycle 1: 8 mg/kg IV over 90 mins
Maintenance dose: 6 mg/kg IV infused over 30 to 90 minutes every 3 Weeks in combination with cisplatin and capecitabine/fluorouracil for 6 cycles



danazol 

Mild condition: 200-400 mg/day orally divided twice daily
Moderate to severe condition: 800 mg/day orally divided twice daily
Decrease the dose accordingly to sustain amenorrhea
Continue the therapy ranging from 6-9 months



megestrol 

Indicated for reducing the pain and symptoms due to advanced endometrial carcinoma
40-320 mg orally each day in divided doses
Check on the efficacy 2 months post-treatment
A maximum dose of up to 800 mg/day can be utilized
It shouldn’t be used as a substitute for radiotherapy, chemotherapy, or surgery



medroxyprogesterone 

Indicated for Metastatic Endometrial Carcinoma
Depo-Provera is only indicated for relieving the symptoms of recurrent, metastatic, or inoperable endometrial carcinoma
Initially 400-1000 mg intramuscularly each week



dostarlimab 

For the Initial dose
Dose 1 to Dose 4-Intravenous infusion of 500 mg for 30 minutes, repeated every three weeks
For the Maintenance dose
Starting from 3 weeks after Dose 4 (Dose 5 onwards)- Intravenous infusion of 1000 mg for 30 minutes, given for six weeks



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Founded in 2014, medtigo is committed to providing high-quality, friendly physicians, transparent pricing, and a focus on building relationships and a lifestyle brand for medical professionals nationwide.

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CONTACT INFORMATION

ADDRESS

MASSACHUSETTS – USA

60 Roberts Drive, Suite 313,
North Adams, MA 01247

MAHARASHTRA – INDIA

7, Shree Krishna, 2nd Floor,
Opp Kiosk Koffee,
Shirole Lane, Off FC Road,
Pune 411004, Maharashtra

 

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