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» Home » CAD » Endocrinology » Metabolic Disorders » Familial Hypercholesterolemia
Background
Epidemiology
Anatomy
Pathophysiology
Etiology
Genetics
Prognostic Factors
Clinical History
Physical Examination
Age group
Associated comorbidity
Associated activity
Acuity of presentation
Differential Diagnoses
Laboratory Studies
Imaging Studies
Procedures
Histologic Findings
Staging
Treatment Paradigm
by Stage
by Modality
Chemotherapy
Radiation Therapy
Surgical Interventions
Hormone Therapy
Immunotherapy
Hyperthermia
Photodynamic Therapy
Stem Cell Transplant
Targeted Therapy
Palliative Care
Medication
Altoprev (Extended release):
10 to 60 mg orally every night at bedtime
Mevacor (Immediate release):
Initial dose: 20 mg orally once daily with an evening meal
may divide the daily dose twice a day;
alter dose at 4-week intervals if necessary; maximum daily dose: 80 mg
Dose Adjustments
Dosing Considerations
Danazol, diltiazem, or verapamil coadministration: Do not take over 20 mg of lovastatin daily.
Amiodarone coadministration: Do not take more than 40 mg of lovastatin daily.
Avoid drinking significant amounts of grapefruit juice (more than 1 quart daily).
Management of overdose
Overdosing on the medicine may cause adverse effects such as peripheral neuropathy, diarrhea, higher LFTs, myopathy, rhabdomyolysis, increased K+, and eye lens opacities.
Supportive care is provided.
Dosing Modifications
Renal Impairment
Renal impairment (severe; CrCl>30 mL/min): Doses more than 20 mg/day should be carefully assessed and, if required, administered cautiously.
Future Trends
References
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» Home » CAD » Endocrinology » Metabolic Disorders » Familial Hypercholesterolemia
Altoprev (Extended release):
10 to 60 mg orally every night at bedtime
Mevacor (Immediate release):
Initial dose: 20 mg orally once daily with an evening meal
may divide the daily dose twice a day;
alter dose at 4-week intervals if necessary; maximum daily dose: 80 mg
Dose Adjustments
Dosing Considerations
Danazol, diltiazem, or verapamil coadministration: Do not take over 20 mg of lovastatin daily.
Amiodarone coadministration: Do not take more than 40 mg of lovastatin daily.
Avoid drinking significant amounts of grapefruit juice (more than 1 quart daily).
Management of overdose
Overdosing on the medicine may cause adverse effects such as peripheral neuropathy, diarrhea, higher LFTs, myopathy, rhabdomyolysis, increased K+, and eye lens opacities.
Supportive care is provided.
Dosing Modifications
Renal Impairment
Renal impairment (severe; CrCl>30 mL/min): Doses more than 20 mg/day should be carefully assessed and, if required, administered cautiously.
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