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Familial Hypercholesterolemia

Updated : September 3, 2022





Background

Epidemiology

Anatomy

Pathophysiology

Etiology

Genetics

Prognostic Factors

Clinical History

Physical Examination

Age group

Associated comorbidity

Associated activity

Acuity of presentation

Differential Diagnoses

Laboratory Studies

Imaging Studies

Procedures

Histologic Findings

Staging

Treatment Paradigm

by Stage

by Modality

Chemotherapy

Radiation Therapy

Surgical Interventions

Hormone Therapy

Immunotherapy

Hyperthermia

Photodynamic Therapy

Stem Cell Transplant

Targeted Therapy

Palliative Care

Medication

 

lovastatin 

Altoprev (Extended release):
10 to 60 mg orally every night at bedtime

Mevacor (Immediate release):
Initial dose: 20 mg orally once daily with an evening meal
may divide the daily dose twice a day;
alter dose at 4-week intervals if necessary; maximum daily dose: 80 mg



Dose Adjustments

Dosing Considerations
Danazol, diltiazem, or verapamil coadministration: Do not take over 20 mg of lovastatin daily.
Amiodarone coadministration: Do not take more than 40 mg of lovastatin daily.
Avoid drinking significant amounts of grapefruit juice (more than 1 quart daily).

Management of overdose
Overdosing on the medicine may cause adverse effects such as peripheral neuropathy, diarrhea, higher LFTs, myopathy, rhabdomyolysis, increased K+, and eye lens opacities.
Supportive care is provided.

Dosing Modifications
Renal Impairment
Renal impairment (severe; CrCl>30 mL/min): Doses more than 20 mg/day should be carefully assessed and, if required, administered cautiously.

simvastatin 

Take a dose of 40 mg orally one time daily
Daily dose should not be more than 40 mg



 

simvastatin 

For >10 years old:
Take an initial dose of 10 mg orally one time daily in evening
Take a maintenance dose of 10 to 40 mg orally one time daily in evening
Daily dose should not be more than 40 mg



 

Media Gallary

References

Familial Hypercholesterolemia

Updated : September 3, 2022




lovastatin 

Altoprev (Extended release):
10 to 60 mg orally every night at bedtime

Mevacor (Immediate release):
Initial dose: 20 mg orally once daily with an evening meal
may divide the daily dose twice a day;
alter dose at 4-week intervals if necessary; maximum daily dose: 80 mg



Dose Adjustments

Dosing Considerations
Danazol, diltiazem, or verapamil coadministration: Do not take over 20 mg of lovastatin daily.
Amiodarone coadministration: Do not take more than 40 mg of lovastatin daily.
Avoid drinking significant amounts of grapefruit juice (more than 1 quart daily).

Management of overdose
Overdosing on the medicine may cause adverse effects such as peripheral neuropathy, diarrhea, higher LFTs, myopathy, rhabdomyolysis, increased K+, and eye lens opacities.
Supportive care is provided.

Dosing Modifications
Renal Impairment
Renal impairment (severe; CrCl>30 mL/min): Doses more than 20 mg/day should be carefully assessed and, if required, administered cautiously.

simvastatin 

Take a dose of 40 mg orally one time daily
Daily dose should not be more than 40 mg



simvastatin 

For >10 years old:
Take an initial dose of 10 mg orally one time daily in evening
Take a maintenance dose of 10 to 40 mg orally one time daily in evening
Daily dose should not be more than 40 mg



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