fbpx

ADVERTISEMENT

ADVERTISEMENT

Familial Hypercholesterolemia

Updated : September 3, 2022





Background

Epidemiology

Anatomy

Pathophysiology

Etiology

Genetics

Prognostic Factors

Clinical History

Physical Examination

Age group

Associated comorbidity

Associated activity

Acuity of presentation

Differential Diagnoses

Laboratory Studies

Imaging Studies

Procedures

Histologic Findings

Staging

Treatment Paradigm

by Stage

by Modality

Chemotherapy

Radiation Therapy

Surgical Interventions

Hormone Therapy

Immunotherapy

Hyperthermia

Photodynamic Therapy

Stem Cell Transplant

Targeted Therapy

Palliative Care

Medication

 

lovastatin 

Altoprev (Extended release):
10 to 60 mg orally every night at bedtime

Mevacor (Immediate release):
Initial dose: 20 mg orally once daily with an evening meal
may divide the daily dose twice a day;
alter dose at 4-week intervals if necessary; maximum daily dose: 80 mg



Dose Adjustments

Dosing Considerations
Danazol, diltiazem, or verapamil coadministration: Do not take over 20 mg of lovastatin daily.
Amiodarone coadministration: Do not take more than 40 mg of lovastatin daily.
Avoid drinking significant amounts of grapefruit juice (more than 1 quart daily).

Management of overdose
Overdosing on the medicine may cause adverse effects such as peripheral neuropathy, diarrhea, higher LFTs, myopathy, rhabdomyolysis, increased K+, and eye lens opacities.
Supportive care is provided.

Dosing Modifications
Renal Impairment
Renal impairment (severe; CrCl>30 mL/min): Doses more than 20 mg/day should be carefully assessed and, if required, administered cautiously.

 
 

Media Gallary

References

ADVERTISEMENT 

Familial Hypercholesterolemia

Updated : September 3, 2022




lovastatin 

Altoprev (Extended release):
10 to 60 mg orally every night at bedtime

Mevacor (Immediate release):
Initial dose: 20 mg orally once daily with an evening meal
may divide the daily dose twice a day;
alter dose at 4-week intervals if necessary; maximum daily dose: 80 mg



Dose Adjustments

Dosing Considerations
Danazol, diltiazem, or verapamil coadministration: Do not take over 20 mg of lovastatin daily.
Amiodarone coadministration: Do not take more than 40 mg of lovastatin daily.
Avoid drinking significant amounts of grapefruit juice (more than 1 quart daily).

Management of overdose
Overdosing on the medicine may cause adverse effects such as peripheral neuropathy, diarrhea, higher LFTs, myopathy, rhabdomyolysis, increased K+, and eye lens opacities.
Supportive care is provided.

Dosing Modifications
Renal Impairment
Renal impairment (severe; CrCl>30 mL/min): Doses more than 20 mg/day should be carefully assessed and, if required, administered cautiously.

Free CME credits

Both our subscription plans include Free CME/CPD AMA PRA Category 1 credits.

Digital Certificate PDF

On course completion, you will receive a full-sized presentation quality digital certificate.

medtigo Simulation

A dynamic medical simulation platform designed to train healthcare professionals and students to effectively run code situations through an immersive hands-on experience in a live, interactive 3D environment.

medtigo Points

medtigo points is our unique point redemption system created to award users for interacting on our site. These points can be redeemed for special discounts on the medtigo marketplace as well as towards the membership cost itself.
 
  • Registration with medtigo = 10 points
  • 1 visit to medtigo’s website = 1 point
  • Interacting with medtigo posts (through comments/clinical cases etc.) = 5 points
  • Attempting a game = 1 point
  • Community Forum post/reply = 5 points

    *Redemption of points can occur only through the medtigo marketplace, courses, or simulation system. Money will not be credited to your bank account. 10 points = $1.

All Your Certificates in One Place

When you have your licenses, certificates and CMEs in one place, it's easier to track your career growth. You can easily share these with hospitals as well, using your medtigo app.

Our Certificate Courses