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» Home » CAD » Gastroenterology » Stomach » Gastrointestinal Stromal Tumors (GISTs)
Background
Epidemiology
Anatomy
Pathophysiology
Etiology
Genetics
Prognostic Factors
Clinical History
Physical Examination
Age group
Associated comorbidity
Associated activity
Acuity of presentation
Differential Diagnoses
Laboratory Studies
Imaging Studies
Procedures
Histologic Findings
Staging
Treatment Paradigm
by Stage
by Modality
Chemotherapy
Radiation Therapy
Surgical Interventions
Hormone Therapy
Immunotherapy
Hyperthermia
Photodynamic Therapy
Stem Cell Transplant
Targeted Therapy
Palliative Care
Medication
300
mg
Tablet
Orally
every day
sunitinib is indicated to treat GIST (Gastrointestinal Stromal Tumor) in case of disease progression or reported intolerance of imatinib mesylate
50 mg orally each day for four weeks
After 2 weeks of drug free stage, repeat the cycle
Continue the medication until the disease reduces
Take 150 mg orally every day
Dosage Modifications
Dose reduction recommendations
Decrease up to 100 mg every day
If not able to tolerate 100 mg/day: discontinue forever
Left ventricular systolic dysfunction
For Grade 3 or 4: discontinue forever
Palmoplantar erythrodysesthesia syndrome (PPES)
For Grade 2
Stop until Grade ≤1, start again at the similar dose if resolved within 7 days, or else start again at a decreased dose
For Grade 3
Stop for a minimum of 7 days and then again start at a decreased dosage
Hypertension
For Grade 3
Grade 3 high blood pressure occurs: Stop until indications cured and blood pressure is managed then start again with lower dose
For Grade 4
Discontinue forever
Arthralgia or myalgia
For Grade 2
Stop until Grade ≤1, start again at the similar dose if resolved within 7 days, or else start again at a decreased dosage
For Grade 3
Stop for a minimum of 7 days and then again start at a decreased dose
Renal impairmen
t
Mild-to-moderate: No clinical observations found
Severe: study not performed
Hepatic impairment
Mild, moderate, or severe: dose modification not required
CYP3A inducers
Strong CYP3A inducers: stop using
Moderate CYP3A inducers: stop using
Dosing Considerations
Confirm the pregnancy status of women who have the potential to conceive before commencing.
Future Trends
References
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» Home » CAD » Gastroenterology » Stomach » Gastrointestinal Stromal Tumors (GISTs)
300
mg
Tablet
Orally
every day
sunitinib is indicated to treat GIST (Gastrointestinal Stromal Tumor) in case of disease progression or reported intolerance of imatinib mesylate
50 mg orally each day for four weeks
After 2 weeks of drug free stage, repeat the cycle
Continue the medication until the disease reduces
Take 150 mg orally every day
Dosage Modifications
Dose reduction recommendations
Decrease up to 100 mg every day
If not able to tolerate 100 mg/day: discontinue forever
Left ventricular systolic dysfunction
For Grade 3 or 4: discontinue forever
Palmoplantar erythrodysesthesia syndrome (PPES)
For Grade 2
Stop until Grade ≤1, start again at the similar dose if resolved within 7 days, or else start again at a decreased dose
For Grade 3
Stop for a minimum of 7 days and then again start at a decreased dosage
Hypertension
For Grade 3
Grade 3 high blood pressure occurs: Stop until indications cured and blood pressure is managed then start again with lower dose
For Grade 4
Discontinue forever
Arthralgia or myalgia
For Grade 2
Stop until Grade ≤1, start again at the similar dose if resolved within 7 days, or else start again at a decreased dosage
For Grade 3
Stop for a minimum of 7 days and then again start at a decreased dose
Renal impairmen
t
Mild-to-moderate: No clinical observations found
Severe: study not performed
Hepatic impairment
Mild, moderate, or severe: dose modification not required
CYP3A inducers
Strong CYP3A inducers: stop using
Moderate CYP3A inducers: stop using
Dosing Considerations
Confirm the pregnancy status of women who have the potential to conceive before commencing.
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