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Group A Streptococcal (GAS) infections

Updated : September 17, 2022





Background

Epidemiology

Anatomy

Pathophysiology

Etiology

Genetics

Prognostic Factors

Clinical History

Physical Examination

Age group

Associated comorbidity

Associated activity

Acuity of presentation

Differential Diagnoses

Laboratory Studies

Imaging Studies

Procedures

Histologic Findings

Staging

Treatment Paradigm

by Stage

by Modality

Chemotherapy

Radiation Therapy

Surgical Interventions

Hormone Therapy

Immunotherapy

Hyperthermia

Photodynamic Therapy

Stem Cell Transplant

Targeted Therapy

Palliative Care

Medication

 

amoxicillin 

500

mg

2 times a day or 1 g daily

10

days


ER: 775 mg daily for 10 days



penicillin G benzathine 

1.2 million units given IM daily as a single dose



erythromycin ethylsuccinate 

400

mg

Orally 

divided in to 2 times a day

10

days



clarithromycin 

Indicated for Streptococcal pharyngitis:


250 mg oral tablet immediate release twice a day for 14 days



cephalexin 

250

mg

Capsule

Orally 

every 6 hrs



cefadroxil 

1

g

orally

daily

10

days


Note: indicated for pharyngitis and tonsillitis caused by Group A beta-hemolytic streptococci



azithromycin 

500 mg orally once a day, followed by 250 mg 4 times a day, on the 2nd to 5th day.



penicillin VK 

125 - 250

mg

Orally 

every 8 hrs

10

days



 

amoxicillin 

Children and Adolescents:  :


50 mg/kg/day orally daily or in divided doses 2 times a day for 10 days; may be increase up to 1,000 mg/day
  ER: 775 mg orally daily for 10 days 



penicillin v 

Age > 12 years:

125 - 250

mg

Orally 

every 6-8 hrs

10

days



penicillin G benzathine 

wt <27 kg: 600,000 U IM daily
wt > 27 kg: 1.2 million U IM daily



cefadroxil 

30

mg/kg

orally

daily



clindamycin 

Indicated for Streptococcal Pharyngitis:

20-30 mg/kg/day orally divided 3 times for Chronic carrier treatment
7 mg/kg/dose 3 times daily for 10 days for Acute treatment



cephalexin 

25 - 50

mg/kg

Capsule

Orally 

every 8 hrs

10

days



 

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References

Group A Streptococcal (GAS) infections

Updated : September 17, 2022




amoxicillin 

500

mg

2 times a day or 1 g daily

10

days


ER: 775 mg daily for 10 days



penicillin G benzathine 

1.2 million units given IM daily as a single dose



erythromycin ethylsuccinate 

400

mg

Orally 

divided in to 2 times a day

10

days



clarithromycin 

Indicated for Streptococcal pharyngitis:


250 mg oral tablet immediate release twice a day for 14 days



cephalexin 

250

mg

Capsule

Orally 

every 6 hrs



cefadroxil 

1

g

orally

daily

10

days


Note: indicated for pharyngitis and tonsillitis caused by Group A beta-hemolytic streptococci



azithromycin 

500 mg orally once a day, followed by 250 mg 4 times a day, on the 2nd to 5th day.



penicillin VK 

125 - 250

mg

Orally 

every 8 hrs

10

days



amoxicillin 

Children and Adolescents:  :


50 mg/kg/day orally daily or in divided doses 2 times a day for 10 days; may be increase up to 1,000 mg/day
  ER: 775 mg orally daily for 10 days 



penicillin v 

Age > 12 years:

125 - 250

mg

Orally 

every 6-8 hrs

10

days



penicillin G benzathine 

wt <27 kg: 600,000 U IM daily
wt > 27 kg: 1.2 million U IM daily



cefadroxil 

30

mg/kg

orally

daily



clindamycin 

Indicated for Streptococcal Pharyngitis:

20-30 mg/kg/day orally divided 3 times for Chronic carrier treatment
7 mg/kg/dose 3 times daily for 10 days for Acute treatment



cephalexin 

25 - 50

mg/kg

Capsule

Orally 

every 8 hrs

10

days