Hodgkin’s Disease

Updated: April 26, 2022

Background

Epidemiology

Anatomy

Pathophysiology

Etiology

Genetics

Prognostic Factors

Clinical History

Physical Examination

Age group

Associated comorbidity

Associated activity

Acuity of presentation

Differential Diagnoses

Laboratory Studies

Imaging Studies

Procedures

Histologic Findings

Staging

Treatment Paradigm

by Stage

by Modality

Chemotherapy

Radiation Therapy

Surgical Interventions

Hormone Therapy

Immunotherapy

Hyperthermia

Photodynamic Therapy

Stem Cell Transplant

Targeted Therapy

Palliative Care

Medication

procarbazine

Initial Dose:

2 - 4

mg/kg

Capsules

Orally 

every day

in single or divided doses for seven days

Maintenance Dose: 4 to 6 mg/kg/day orally until a maximum response is attained, or until the white blood count falls below 4000 cells/mm3 or the platelets fall below 100,000 cells/mm3

After the maximum response is obtained, the dosage may be reduced to 1 to 2 mg/kg/day orally
If it is hematologic or other toxicity, stop the treatment until a full recovery has been achieved. After considering the patient's assessment and laboratory results, the doctor may restart treatment at 1 to 2 mg/kg/day

gallium citrate Ga-67

For adult weight 70 kg: The recommended dose is 74-185 MBq, which is equivalent to 2-5 MCi
The injection is for IV administration

chlorambucil

A dose of 4 to 10 mg or 0.1-0.2 mg per kg given orally as a single dose per day for 3-6 weeks
Hodgkin's disease 0.2 mg per kg per day is recommended
Other lymphomas or chronic lymphocytic leukemia 0.1 mg per kg per day is recommended

chlorambucil

The drug dosage is not recommended to the children < 17 years, but if the condition of lymphoma or Hodgkin’s lymphoma is present in the children the adult dosage is followed

Future Trends