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Hodgkin’s Disease

Updated : April 26, 2022





Background

Epidemiology

Anatomy

Pathophysiology

Etiology

Genetics

Prognostic Factors

Clinical History

Physical Examination

Age group

Associated comorbidity

Associated activity

Acuity of presentation

Differential Diagnoses

Laboratory Studies

Imaging Studies

Procedures

Histologic Findings

Staging

Treatment Paradigm

by Stage

by Modality

Chemotherapy

Radiation Therapy

Surgical Interventions

Hormone Therapy

Immunotherapy

Hyperthermia

Photodynamic Therapy

Stem Cell Transplant

Targeted Therapy

Palliative Care

Medication

 

procarbazine 

Initial Dose:

2 - 4

mg/kg

Capsules

Orally 

every day

in single or divided doses for seven days

Maintenance Dose: 4 to 6 mg/kg/day orally until a maximum response is attained, or until the white blood count falls below 4000 cells/mm3 or the platelets fall below 100,000 cells/mm3

After the maximum response is obtained, the dosage may be reduced to 1 to 2 mg/kg/day orally
If it is hematologic or other toxicity, stop the treatment until a full recovery has been achieved. After considering the patient's assessment and laboratory results, the doctor may restart treatment at 1 to 2 mg/kg/day



 
 

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References

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Hodgkin’s Disease

Updated : April 26, 2022




procarbazine 

Initial Dose:

2 - 4

mg/kg

Capsules

Orally 

every day

in single or divided doses for seven days

Maintenance Dose: 4 to 6 mg/kg/day orally until a maximum response is attained, or until the white blood count falls below 4000 cells/mm3 or the platelets fall below 100,000 cells/mm3

After the maximum response is obtained, the dosage may be reduced to 1 to 2 mg/kg/day orally
If it is hematologic or other toxicity, stop the treatment until a full recovery has been achieved. After considering the patient's assessment and laboratory results, the doctor may restart treatment at 1 to 2 mg/kg/day



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