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» Home » CAD » Endocrinology » Thyroid » Hyperthyroidism and Thyrotoxicosis
Background
Epidemiology
Anatomy
Pathophysiology
Etiology
Genetics
Prognostic Factors
Clinical History
Physical Examination
Age group
Associated comorbidity
Associated activity
Acuity of presentation
Differential Diagnoses
Laboratory Studies
Imaging Studies
Procedures
Histologic Findings
Staging
Treatment Paradigm
by Stage
by Modality
Chemotherapy
Radiation Therapy
Surgical Interventions
Hormone Therapy
Immunotherapy
Hyperthermia
Photodynamic Therapy
Stem Cell Transplant
Targeted Therapy
Palliative Care
Medication
Mild dose- 15 mg/day orally divided 3 times daily, depending on the severity of the condition
Moderate- Initially 30-40 mg/day orally divided 3 times daily
Severe- 60 mg/day orally divided 3 times daily
Maintenance dose- 5-30 mg/day orally divided 3 times daily
Thyrotoxicosis
(Off-label)
15-20 mg orally every 4 hours in the initial day as an adjunct
Reduce the frequency to each day or every 12 hours once patient gets stable
300-450 mg orally divided every 8 hours, depending on the severity of the condition
(A dose of 600-900 mg/day maybe required)
Maintenance dose- 100-150 mg orally divided every 8 hours
Thyrotoxic Crisis
(Off-label)
Initially 200-300 mg orally every 4-6 hours on 1st day
Reduce the dose gradually
Maintenance dose- 100-150 mg/day divided 2-3 times daily
4-10 mCi orally (or 148-370 MBq)
Larger doses are required in the case of toxic nodular goiters, and several other severe thyroid conditions
Initially 0.5-0.7 mg/kg orally each day or divided 3 times daily
Maintenance dose- 0.2 mg/kg orally each day or divided 3 times daily
Do not exceed more than 30 mg/day
Thyrotoxicosis
(Off-Label)
0.5-1 mg/kg orally divided 3 times daily
Based on the patient’s response, adjust the subsequent doses/duration of treatment
Indicated in children for hyperthyroidism only
For neonates, less than 28 days old: 5-10 mg/kg orally divided 3 times daily
For <6 years: 5-7 mg/kg orally divided 3 times daily
For 6-10 years: 50-150 mg orally divided 3 times daily
For >10 years: 150-300 mg orally divided daily
Maintenance dose: Usually one to two third of the intial dose 2-3 times daily based on the response
Future Trends
References
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» Home » CAD » Endocrinology » Thyroid » Hyperthyroidism and Thyrotoxicosis
Mild dose- 15 mg/day orally divided 3 times daily, depending on the severity of the condition
Moderate- Initially 30-40 mg/day orally divided 3 times daily
Severe- 60 mg/day orally divided 3 times daily
Maintenance dose- 5-30 mg/day orally divided 3 times daily
Thyrotoxicosis
(Off-label)
15-20 mg orally every 4 hours in the initial day as an adjunct
Reduce the frequency to each day or every 12 hours once patient gets stable
300-450 mg orally divided every 8 hours, depending on the severity of the condition
(A dose of 600-900 mg/day maybe required)
Maintenance dose- 100-150 mg orally divided every 8 hours
Thyrotoxic Crisis
(Off-label)
Initially 200-300 mg orally every 4-6 hours on 1st day
Reduce the dose gradually
Maintenance dose- 100-150 mg/day divided 2-3 times daily
4-10 mCi orally (or 148-370 MBq)
Larger doses are required in the case of toxic nodular goiters, and several other severe thyroid conditions
Initially 0.5-0.7 mg/kg orally each day or divided 3 times daily
Maintenance dose- 0.2 mg/kg orally each day or divided 3 times daily
Do not exceed more than 30 mg/day
Thyrotoxicosis
(Off-Label)
0.5-1 mg/kg orally divided 3 times daily
Based on the patient’s response, adjust the subsequent doses/duration of treatment
Indicated in children for hyperthyroidism only
For neonates, less than 28 days old: 5-10 mg/kg orally divided 3 times daily
For <6 years: 5-7 mg/kg orally divided 3 times daily
For 6-10 years: 50-150 mg orally divided 3 times daily
For >10 years: 150-300 mg orally divided daily
Maintenance dose: Usually one to two third of the intial dose 2-3 times daily based on the response
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