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Liver Transplantation

Updated : July 16, 2024





Background

Epidemiology

Anatomy

Pathophysiology

Etiology

Genetics

Prognostic Factors

Clinical History

Physical Examination

Age group

Associated comorbidity

Associated activity

Acuity of presentation

Differential Diagnoses

Laboratory Studies

Imaging Studies

Procedures

Histologic Findings

Staging

Treatment Paradigm

by Stage

by Modality

Chemotherapy

Radiation Therapy

Surgical Interventions

Hormone Therapy

Immunotherapy

Hyperthermia

Photodynamic Therapy

Stem Cell Transplant

Targeted Therapy

Palliative Care

Medication

 

hepatitis B immune globulin (HBIG) 

indicated for Liver Transplant (HepaGam only)
developed to achieve serum levels of (HBsAb >500 IU/L)
20,000 IU administered intravenously
Initial dose admin together w/grafting of transplanted liver
For the first seven days after the operation, take the medication daily
Then, from weeks two to twelve post-op, take the medication every two weeks After that, starting from the fourth month, take the medication once a month



mycophenolate 

Note: The concurrent administration of this medication alongside cyclosporine and corticosteroids is recommended for the prevention of organ rejection in individuals who have undergone allogeneic hepatic transplants MMF (IV): Administer 1 gram twice a day, intravenously, with a minimum infusion duration of 2 hours or longer MMF (PO): Administer a dosage of 1.5 grams twice a day



 

mycophenolate 

only CellCept
Note: Recommended for the prevention of organ rejection in pediatric patients aged three months or older who have undergone allogeneic hepatic transplantation when used in conjunction with other immunosuppressive medications
Suspension: The recommended starting dose of suspension is 600 mg/m² twice daily by oral route
If the patient tolerates this dose, The maintenance dose of 900 mg/ m² can increased and administered twice daily with a maximum daily limit of 3 grams
Capsules: For patients with a body surface area (BSA) between 1.25 and less than 1.5 m², the initial recommended dose is a capsule 750 mg twice daily by oral route
The maintenance dose may be increased but should not exceed 3 grams/day
Capsules or tablets: Patients with a BSA of 1.5 m² or greater should start with a 1-gram tablet/capsule twice daily by oral route
The maintenance dose may be increased but should not exceed 3 grams/day



 

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References

Liver Transplantation

Updated : July 16, 2024




hepatitis B immune globulin (HBIG) 

indicated for Liver Transplant (HepaGam only)
developed to achieve serum levels of (HBsAb >500 IU/L)
20,000 IU administered intravenously
Initial dose admin together w/grafting of transplanted liver
For the first seven days after the operation, take the medication daily
Then, from weeks two to twelve post-op, take the medication every two weeks After that, starting from the fourth month, take the medication once a month



mycophenolate 

Note: The concurrent administration of this medication alongside cyclosporine and corticosteroids is recommended for the prevention of organ rejection in individuals who have undergone allogeneic hepatic transplants MMF (IV): Administer 1 gram twice a day, intravenously, with a minimum infusion duration of 2 hours or longer MMF (PO): Administer a dosage of 1.5 grams twice a day



mycophenolate 

only CellCept
Note: Recommended for the prevention of organ rejection in pediatric patients aged three months or older who have undergone allogeneic hepatic transplantation when used in conjunction with other immunosuppressive medications
Suspension: The recommended starting dose of suspension is 600 mg/m² twice daily by oral route
If the patient tolerates this dose, The maintenance dose of 900 mg/ m² can increased and administered twice daily with a maximum daily limit of 3 grams
Capsules: For patients with a body surface area (BSA) between 1.25 and less than 1.5 m², the initial recommended dose is a capsule 750 mg twice daily by oral route
The maintenance dose may be increased but should not exceed 3 grams/day
Capsules or tablets: Patients with a BSA of 1.5 m² or greater should start with a 1-gram tablet/capsule twice daily by oral route
The maintenance dose may be increased but should not exceed 3 grams/day