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Metabolic Acidosis

Updated : December 14, 2022





Background

Epidemiology

Anatomy

Pathophysiology

Etiology

Genetics

Prognostic Factors

Clinical History

Physical Examination

Age group

Associated comorbidity

Associated activity

Acuity of presentation

Differential Diagnoses

Laboratory Studies

Imaging Studies

Procedures

Histologic Findings

Staging

Treatment Paradigm

by Stage

by Modality

Chemotherapy

Radiation Therapy

Surgical Interventions

Hormone Therapy

Immunotherapy

Hyperthermia

Photodynamic Therapy

Stem Cell Transplant

Targeted Therapy

Palliative Care

Medication

 

sodium lactate 


Indicated for Alkalinizing Agent
Depending upon the severity of the metabolic acidosis, the dosage is directed by a physician



sodium bicarbonate 

Not posing a threat to life: Intravenous infusion of 2 to 5 milliequivalents/kg over a period of 4 to 8 hours based on the severity of acidosis as determined by the decrease in total CO2 content, clinical state and pH.
Severe (except hyper carbic acidosis): 90 to 180 milliequivalents/liter at a pace of 1 to 1.5 liters during the first hour and adjust for subsequent treatment as required
Dosing Considerations Observe serum potassium, carbon di oxide and pH



veverimer(Pending FDA approval) 

Metabolic acidosis in individuals with chronic renal disease: Pending FDA clearance



 

sodium lactate 


Indicated for Alkalinizing Agent
Depending upon the severity of the metabolic acidosis, the dosage is directed by a physician



sodium bicarbonate 

For older children: Administer an intravenous infusion of 2 to 5 milliequivalent/kg over a period of 4 to 8 hours, depending on the extent of acidosis as determined by the decrease in total CO2 content, clinical condition and pH level
In cases of acidosis with a pH level below 7.0 to 7.2, an intravenous infusion of 0.25 to 2 milliequivalent/kg can be considered
Dosing Considerations Observe the serum potassium



 

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References

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Metabolic Acidosis

Updated : December 14, 2022




sodium lactate 


Indicated for Alkalinizing Agent
Depending upon the severity of the metabolic acidosis, the dosage is directed by a physician



sodium bicarbonate 

Not posing a threat to life: Intravenous infusion of 2 to 5 milliequivalents/kg over a period of 4 to 8 hours based on the severity of acidosis as determined by the decrease in total CO2 content, clinical state and pH.
Severe (except hyper carbic acidosis): 90 to 180 milliequivalents/liter at a pace of 1 to 1.5 liters during the first hour and adjust for subsequent treatment as required
Dosing Considerations Observe serum potassium, carbon di oxide and pH



veverimer(Pending FDA approval) 

Metabolic acidosis in individuals with chronic renal disease: Pending FDA clearance



sodium lactate 


Indicated for Alkalinizing Agent
Depending upon the severity of the metabolic acidosis, the dosage is directed by a physician



sodium bicarbonate 

For older children: Administer an intravenous infusion of 2 to 5 milliequivalent/kg over a period of 4 to 8 hours, depending on the extent of acidosis as determined by the decrease in total CO2 content, clinical condition and pH level
In cases of acidosis with a pH level below 7.0 to 7.2, an intravenous infusion of 0.25 to 2 milliequivalent/kg can be considered
Dosing Considerations Observe the serum potassium



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