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Pancreatic Cancer

Updated : September 16, 2022



Background

Epidemiology

Anatomy

Pathophysiology

Etiology

Genetics

Prognostic Factors

Clinical History

Physical Examination

Age group

Associated comorbidity

Associated activity

Acuity of presentation

Differential Diagnoses

Laboratory Studies

Imaging Studies

Procedures

Histologic Findings

Staging

Treatment Paradigm

by Stage

by Modality

Chemotherapy

Radiation Therapy

Surgical Interventions

Hormone Therapy

Immunotherapy

Hyperthermia

Photodynamic Therapy

Stem Cell Transplant

Targeted Therapy

Palliative Care

Medication

 

fluorouracil 

400 mg/m² of intravenous pyelogram on 1st day, followed by 2400 mg/m² intravenously continuously for 46 hours every 2 weeks
multidrug chemotherapy regimen
For multidrug chemotherapy regimen combined with leucovorin 400 mg/m² intravenous pyelogram on 1st day, followed by 2400 mg/m² intravenously for 46 hours every 2 weeks



gemcitabine 

Indicated for pancreatic cancer as single agent 1000 mg/m2 intravenously once a week for 3 weeks in a 28-day cycle
It can also be used if combined with paclitaxel, erlotinib, capecitabine)



mitomycin 

Indicated for Pancreatic Cancer, Stomach cancer:


20mg/m2 intravenous every 6 to 8 weeks



irinotecan liposomal 


Indicated for Pancreatic Cancer
Administer the irinotecan liposomal before fluorouracil and leucovorin 70 mg/m² intravenous infusion over 1 hour 30 min every two weeks Pre-treatment with the antiemetic agent and corticosteroid 30 minutes prior to irinotecan liposomal infusion
It is used in combination with leucovorin and fluorouracil for the metastatic adenocarcinoma of the pancreas following disease progression occurs after gemcitabine-based treatment
Dose modifications
For patients who are homozygous for the UGT1A1*28 alleles: 50 mg/m² intravenous infusion over 1 hour 30 min every two weeks; enhance the dose to 70 mg/m² as well tolerated in following cycles
Adverse reactions in grade 3 or grade 4
Retain the dose
When it reaches grade 1, restart the dose at,
1st occurrence: Restart dose at 50 mg/m² or at 43 mg/m²
2nd occurrence: Restart dose at 43 mg/m² or at 35 mg/m²
For Diarrhea as a side effect: Retain the dose; start loperamide for the late-onset diarrhea; administer intravenous or subcutaneous atropine 0.25 mg-1 mg for the early-onset diarrhea



 
 

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Pancreatic Cancer

Updated : September 16, 2022


fluorouracil 

400 mg/m² of intravenous pyelogram on 1st day, followed by 2400 mg/m² intravenously continuously for 46 hours every 2 weeks
multidrug chemotherapy regimen
For multidrug chemotherapy regimen combined with leucovorin 400 mg/m² intravenous pyelogram on 1st day, followed by 2400 mg/m² intravenously for 46 hours every 2 weeks



gemcitabine 

Indicated for pancreatic cancer as single agent 1000 mg/m2 intravenously once a week for 3 weeks in a 28-day cycle
It can also be used if combined with paclitaxel, erlotinib, capecitabine)



mitomycin 

Indicated for Pancreatic Cancer, Stomach cancer:


20mg/m2 intravenous every 6 to 8 weeks



irinotecan liposomal 


Indicated for Pancreatic Cancer
Administer the irinotecan liposomal before fluorouracil and leucovorin 70 mg/m² intravenous infusion over 1 hour 30 min every two weeks Pre-treatment with the antiemetic agent and corticosteroid 30 minutes prior to irinotecan liposomal infusion
It is used in combination with leucovorin and fluorouracil for the metastatic adenocarcinoma of the pancreas following disease progression occurs after gemcitabine-based treatment
Dose modifications
For patients who are homozygous for the UGT1A1*28 alleles: 50 mg/m² intravenous infusion over 1 hour 30 min every two weeks; enhance the dose to 70 mg/m² as well tolerated in following cycles
Adverse reactions in grade 3 or grade 4
Retain the dose
When it reaches grade 1, restart the dose at,
1st occurrence: Restart dose at 50 mg/m² or at 43 mg/m²
2nd occurrence: Restart dose at 43 mg/m² or at 35 mg/m²
For Diarrhea as a side effect: Retain the dose; start loperamide for the late-onset diarrhea; administer intravenous or subcutaneous atropine 0.25 mg-1 mg for the early-onset diarrhea



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Founded in 2014, medtigo is committed to providing high-quality, friendly physicians, transparent pricing, and a focus on building relationships and a lifestyle brand for medical professionals nationwide.

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CONTACT INFORMATION

ADDRESS

MASSACHUSETTS – USA

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North Adams, MA 01247

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Opp Kiosk Koffee,
Shirole Lane, Off FC Road,
Pune 411004, Maharashtra

 

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