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Perioperative Blood Management

Updated : October 4, 2022





Background

Epidemiology

Anatomy

Pathophysiology

Etiology

Genetics

Prognostic Factors

Clinical History

Physical Examination

Age group

Associated comorbidity

Associated activity

Acuity of presentation

Differential Diagnoses

Laboratory Studies

Imaging Studies

Procedures

Histologic Findings

Staging

Treatment Paradigm

by Stage

by Modality

Chemotherapy

Radiation Therapy

Surgical Interventions

Hormone Therapy

Immunotherapy

Hyperthermia

Photodynamic Therapy

Stem Cell Transplant

Targeted Therapy

Palliative Care

Medication

 

omidubicel-onlv 


Indicated for Umbilical Cord Blood Transplantation
Administer conditioning dosage regimen before infusion, as per institutional guidelines
A single dose consists of the following:
Cultured Fraction: 8 x 108 total viable cells (i.e., 8.7% is CD34+ cells), which is a minimum of the 9.2 x 107 CD34+ cells suspended in nearly 10% DMSO
Non-Cultured Fraction: 4 x 108 total viable cells which is a minimum of the 2.4 x 107 CD34+ cells suspended in nearly 10% DMSO
See respective COA (Certificate of Analysis) for the Cultured Fraction and Non-cultured Fraction for actual cell counts
cultured fraction and Non-cultured fraction are generally supplied by cryopreservation in two bags
Before administering, thaw and dilute with two infusion solution bags (one for cultured fraction and another for Non-cultured fraction)
Start infusing Non-cultured fraction bag within one hour after completion of Cultured fraction



 

omidubicel-onlv 


Indicated for Umbilical Cord Blood Transplantation
Age >12 years
Administer conditioning dosage regimen before infusion, as per institutional guidelines
A single dose consists of the following:
Cultured Fraction: 8 x 108 total viable cells (i.e., 8.7% is CD34+ cells), which is a minimum of the 9.2 x 107 CD34+ cells suspended in nearly 10% DMSO
Non-Cultured Fraction: 4 x 108 total viable cells which is a minimum of the 2.4 x 107 CD34+ cells suspended in nearly 10% DMSO
See respective COA (Certificate of Analysis) for the Cultured Fraction and Non-cultured Fraction for actual cell counts
cultured fraction and Non-cultured fraction are generally supplied by cryopreservation in two bags
Before administering, thaw and dilute with two infusion solution bags (one for cultured fraction and another for Non-cultured fraction)
Start infusing Non-cultured fraction bag within one hour after completion of Cultured fraction



 

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References

Perioperative Blood Management

Updated : October 4, 2022




omidubicel-onlv 


Indicated for Umbilical Cord Blood Transplantation
Administer conditioning dosage regimen before infusion, as per institutional guidelines
A single dose consists of the following:
Cultured Fraction: 8 x 108 total viable cells (i.e., 8.7% is CD34+ cells), which is a minimum of the 9.2 x 107 CD34+ cells suspended in nearly 10% DMSO
Non-Cultured Fraction: 4 x 108 total viable cells which is a minimum of the 2.4 x 107 CD34+ cells suspended in nearly 10% DMSO
See respective COA (Certificate of Analysis) for the Cultured Fraction and Non-cultured Fraction for actual cell counts
cultured fraction and Non-cultured fraction are generally supplied by cryopreservation in two bags
Before administering, thaw and dilute with two infusion solution bags (one for cultured fraction and another for Non-cultured fraction)
Start infusing Non-cultured fraction bag within one hour after completion of Cultured fraction



omidubicel-onlv 


Indicated for Umbilical Cord Blood Transplantation
Age >12 years
Administer conditioning dosage regimen before infusion, as per institutional guidelines
A single dose consists of the following:
Cultured Fraction: 8 x 108 total viable cells (i.e., 8.7% is CD34+ cells), which is a minimum of the 9.2 x 107 CD34+ cells suspended in nearly 10% DMSO
Non-Cultured Fraction: 4 x 108 total viable cells which is a minimum of the 2.4 x 107 CD34+ cells suspended in nearly 10% DMSO
See respective COA (Certificate of Analysis) for the Cultured Fraction and Non-cultured Fraction for actual cell counts
cultured fraction and Non-cultured fraction are generally supplied by cryopreservation in two bags
Before administering, thaw and dilute with two infusion solution bags (one for cultured fraction and another for Non-cultured fraction)
Start infusing Non-cultured fraction bag within one hour after completion of Cultured fraction



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