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Pneumocystis jiroveci Pneumonia(PJP)

Updated : September 17, 2022



Background

Epidemiology

Anatomy

Pathophysiology

Etiology

Genetics

Prognostic Factors

Clinical History

Physical Examination

Age group

Associated comorbidity

Associated activity

Acuity of presentation

Differential Diagnoses

Laboratory Studies

Imaging Studies

Procedures

Histologic Findings

Staging

Treatment Paradigm

by Stage

by Modality

Chemotherapy

Radiation Therapy

Surgical Interventions

Hormone Therapy

Immunotherapy

Hyperthermia

Photodynamic Therapy

Stem Cell Transplant

Targeted Therapy

Palliative Care

Medication

 

pentamidine 


Prophylaxis: 4 mg/kg intravenous or intramuscular every two-three weeks or Nebulized 300 mg every four weeks
Treatment: 4 mg/kg intravenous or intramuscular every day for 14-21 days
African Trypanosomiasis as Off-label
4 mg/kg intramuscular every day for 10 days
Leishmaniasis as Off-label
Cutaneous: 2 mg/kg intravenous or intramuscular one time a day for 7 doses
Or
3 mg/kg intramuscular one time a day for 4 doses
Visceral: 2-4 mg/kg intramuscular every one-two days for 15-30 doses
Renal Impairment
CrCl >10 mL/min: Dose adjustment not needed
CrCl <10 mL/min: 4 mg/kg intravenous or intramuscular every 24-36 hours



methylprednisolone 

(Off-label):

30 mg intravenous every 2 times a day for 5 days, following 30 mg intravenous every day for 5 days, following 15 mg intravenous every day for 11 days



 

pentamidine 


Age >4 months
Prophylaxis: 4 mg/kg intravenous or intramuscular every two-three weeks or Nebulized 300 mg every four weeks
Treatment: 4 mg/kg intravenous or intramuscular every day for 14-21 days
Age <4 months
Safety and efficacy not established
African Trypanosomiasis as Off-label
4 mg/kg intramuscular every day for 10 days
Leishmaniasis as Off-label
Cutaneous: 2 mg/kg intravenous or intramuscular one time a day for 7 doses
Or
3 mg/kg intramuscular one time a day for 4 doses
Visceral: 2-4 mg/kg intramuscular every one-two days for 15-30 doses
Renal Impairment
CrCl >30 mL/min: Dose adjustment not needed
CrCl 10-30 mL/min: 4 mg/kg intravenous or intramuscular every 36 hours
CrCl <10 mL/min: 4 mg/kg intravenous or intramuscular every 48 hours
Hemodialysis: 4 mg/kg intravenous or intramuscular every 48 hours after the dialysis on the dialysis day



methylprednisolone 

Above 13 yrs: 30 mg intravenous every 2 times a day for 5 days, following 30 mg Intravenous every day for 5 days, following 15 mg Intravenous every day for 11 days



 

Media Gallary

References

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Pneumocystis jiroveci Pneumonia(PJP)

Updated : September 17, 2022


pentamidine 


Prophylaxis: 4 mg/kg intravenous or intramuscular every two-three weeks or Nebulized 300 mg every four weeks
Treatment: 4 mg/kg intravenous or intramuscular every day for 14-21 days
African Trypanosomiasis as Off-label
4 mg/kg intramuscular every day for 10 days
Leishmaniasis as Off-label
Cutaneous: 2 mg/kg intravenous or intramuscular one time a day for 7 doses
Or
3 mg/kg intramuscular one time a day for 4 doses
Visceral: 2-4 mg/kg intramuscular every one-two days for 15-30 doses
Renal Impairment
CrCl >10 mL/min: Dose adjustment not needed
CrCl <10 mL/min: 4 mg/kg intravenous or intramuscular every 24-36 hours



methylprednisolone 

(Off-label):

30 mg intravenous every 2 times a day for 5 days, following 30 mg intravenous every day for 5 days, following 15 mg intravenous every day for 11 days



pentamidine 


Age >4 months
Prophylaxis: 4 mg/kg intravenous or intramuscular every two-three weeks or Nebulized 300 mg every four weeks
Treatment: 4 mg/kg intravenous or intramuscular every day for 14-21 days
Age <4 months
Safety and efficacy not established
African Trypanosomiasis as Off-label
4 mg/kg intramuscular every day for 10 days
Leishmaniasis as Off-label
Cutaneous: 2 mg/kg intravenous or intramuscular one time a day for 7 doses
Or
3 mg/kg intramuscular one time a day for 4 doses
Visceral: 2-4 mg/kg intramuscular every one-two days for 15-30 doses
Renal Impairment
CrCl >30 mL/min: Dose adjustment not needed
CrCl 10-30 mL/min: 4 mg/kg intravenous or intramuscular every 36 hours
CrCl <10 mL/min: 4 mg/kg intravenous or intramuscular every 48 hours
Hemodialysis: 4 mg/kg intravenous or intramuscular every 48 hours after the dialysis on the dialysis day



methylprednisolone 

Above 13 yrs: 30 mg intravenous every 2 times a day for 5 days, following 30 mg Intravenous every day for 5 days, following 15 mg Intravenous every day for 11 days



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Founded in 2014, medtigo is committed to providing high-quality, friendly physicians, transparent pricing, and a focus on building relationships and a lifestyle brand for medical professionals nationwide.

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CONTACT INFORMATION

ADDRESS

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North Adams, MA 01247

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Opp Kiosk Koffee,
Shirole Lane, Off FC Road,
Pune 411004, Maharashtra

 

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