Pregnancy termination

Updated: July 15, 2024

Background

Epidemiology

Anatomy

Pathophysiology

Etiology

Genetics

Prognostic Factors

Clinical History

Physical Examination

Age group

Associated comorbidity

Associated activity

Acuity of presentation

Differential Diagnoses

Laboratory Studies

Imaging Studies

Procedures

Histologic Findings

Staging

Treatment Paradigm

by Stage

by Modality

Chemotherapy

Radiation Therapy

Surgical Interventions

Hormone Therapy

Immunotherapy

Hyperthermia

Photodynamic Therapy

Stem Cell Transplant

Targeted Therapy

Palliative Care

Medication

dinoprostone

20mg suppository intravaginal every 3-5 hours until abortion occurs
Do not exceed more than two days of administration continuously

carboprost tromethamine

250mcg intramuscular initially, repeat whenever necessary every 1.5 to 3 hours or
An optional test dose of 100mcg intramuscularly, then increase the dose to 500mcg
Do not exceed 1200mcg or continuous administration for two days

misoprostol

See drug monograph of mifepristone (Mifeprex) for the FDA-approved dose regimen

mifepristone

Day 1: 200 mg mifepristone orally as a single dosage
Days 2 to 3: 800 mcg misoprostol buccally once as the single dosage; should be administered at least 24-hours and a maximum of 48-hours following mifepristone dose on the day 1
Follow up with the healthcare provider 7 to 14 days after taking the Mifeprex
Days 7 to 14
If complete expulsion has not happened, but the pregnancy is not continuing, women may be given another dosage of 800 mcg misoprostol buccally with a one-week follow-up

mifepristone and misoprostol

Indicated for Intrauterine pregnancy termination
Day-1: mifepristone 200 mg orally one dose in individuals of 63 days of gestation
Day-2 or Day-3: misoprostol 800 mcg as buccal route one to two days following mifepristone
It is administered as four 200 mcg of misoprostol tablets as it is placed between gum and cheek and held for nearly 30 minutes
Day-7 to Day-14(Post-therapy): Individuals should follow up with the health care professional 7-14 days following mifepristone administration for confirmation of pregnancy termination
Surgical termination might be required if the failure of treatment
Pregnancy termination as off-label
mifepristone 200 mg orally after that, misoprostol 800 mcg as buccal route, sublingually/Vaginal route one to two days later in individuals of 70 days of gestation