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Riboflavin Deficiency

Updated : February 14, 2024





Background

The body requires riboflavin, often known as vitamin B2, which is water-soluble and heat-stable, to convert proteins, carbs, and lipids into glucose for energy. This vitamin not only increases energy but also serves as an antioxidant for immune function, smooth skin, and strong hair.

When there is a riboflavin deficiency, the body is unable to metabolize macronutrients such as lipids, proteins, and carbs for maintenance. For healthy growth, lactation, physical ability, and reproduction, riboflavin is required.

This activity discusses the role of the interprofessional team in enhancing care for individuals with this condition and exhibits the examination and therapy of riboflavin insufficiency.

Objectives:

  • Become familiar with the causes of riboflavin insufficiency.
  • Describe the evaluation of a riboflavin-deficient patient.
  • List the remedies for riboflavin insufficiency in brief.
  • To improve the provision of care for those with riboflavin deficiency, discuss the significance of better care coordination among the interprofessional team members. This will help patients understand how important riboflavin is for healthy development, milk production, physical ability, and reproductive capacity.

The body uses the heat-stable and water-soluble vitamin riboflavin, often known as vitamin B2, to convert lipids, proteins, and carbs into energy using glucose. Riboflavin not only increases energy but also serves as an antioxidant for immune function, hair health, and skin. The coenzymes FMN (flavin mononucleotide) and FAD (flavin adenine dinucleotide) enable these effects to take place (FAD).

The body cannot metabolize and maintain macronutrients like proteins, carbohydrates, and lipids without enough riboflavin. It is crucial to obtain the majority of riboflavin from dietary sources since the body can absorb the majority of nutrients from the diet with a healthy digestive system. The yellow-green, fluorescent pigment in riboflavin causes urine to become yellow, a sign that the body is absorbing it.

Niacin, which stimulates vitamin B6, is produced when tryptophan is transformed into riboflavin. Anemia, cataracts, migraines, and thyroid dysfunction are a few avoidable disorders that can be treated with enough riboflavin. For healthy growth, lactating, physical ability, and reproductive, riboflavin is required.

Epidemiology

In the US, riboflavin deficiency is incredibly uncommon. The majority of riboflavin deficient cases occur in poor nations in Africa and Asia. Since the body cannot absorb much riboflavin when taking birth control pills, older persons, women, and drinkers are more prone to experience riboflavin shortage.

Many developmental problems, including cleft palate and lip, short stature, and cardiovascular illness, can be linked to riboflavin deficiency. Riboflavin insufficiency is also a problem for pregnant and nursing women, those with BVVL (Brown-Vialetto-Van Laere syndrome), and vegans.

Anatomy

Pathophysiology

Riboflavin deficiency has been linked to anemia, which makes people tired, according to research. The formation of RBCs and the delivery of oxygen to the cells both include riboflavin. Riboflavin intake can be improved to boost red cell formation and hemoglobin levels in the blood. The majority of hair and skin contain the protein collagen.

Hence, riboflavin is required to maintain a sufficient collagen quantity. Riboflavin supplements can potentially be used as a migraine treatment. Adult migraine headaches can be prevented by taking 400 mg of riboflavin daily, but this treatment must be taken for at least three months to be effective.

This discovery is most likely due to the fact that mitochondrial malfunction has been linked to migraines and that riboflavin is a progenitor to flavin coenzymes, which are essential for the electron transportation chain. Riboflavin supplementation has been shown to improve encephalopathy, cardiomyopathy, and muscular endurance in patients with mitochondrial complex I impairment.

The eye condition known as a cataract, which results in a hazy lens, can be prevented by consuming riboflavin supplementation. Riboflavin also benefits other eye conditions, including keratoconus and glaucoma, in addition to cataracts. To strengthen the cornea, riboflavin solutions are often applied to the sufferer’s cornea.

Additionally, blood pressure and homocysteine concentrations can be lowered by taking riboflavin supplements. Studies show that a 25% reduction in homocysteine can reduce the risk of stroke and CHD (coronary heart disease). The body produces homocysteine, an amino acid, using methionine that is acquired through dietary variables.

Etiology

A lack of riboflavin in the diet or endocrine disorders can cause a deficit. Additionally, riboflavin insufficiency and other vitamin B compounds are related. Foods, including milk products, grains, meats, green vegetables, and eggs, all naturally contain riboflavin. Riboflavin, the primary antioxidant, and glutathione both function.

Due to the fact that free radicals can result in the development of numerous diseases, glutathione acts to eliminate them and cleanse the liver. Additionally, hemodialysis, alcoholism, liver disease, and chronic diarrhea can all contribute to riboflavin insufficiency.

Genetics

Prognostic Factors

Clinical History

Physical Examination

Age group

Associated comorbidity

Associated activity

Acuity of presentation

Differential Diagnoses

Laboratory Studies

Imaging Studies

Procedures

Histologic Findings

Staging

Treatment Paradigm

by Stage

by Modality

Chemotherapy

Radiation Therapy

Surgical Interventions

Hormone Therapy

Immunotherapy

Hyperthermia

Photodynamic Therapy

Stem Cell Transplant

Targeted Therapy

Palliative Care

Medication

 

vitamin b2 

Supplementing with riboflavin is recommended for adults experiencing syndromes caused by riboflavin deficiency
the appropriate dosage is 6-30 mg per day, taken orally and divided into multiple doses



 

vitamin b2 

The suggested dosage for children aged 3 to 12 years is a daily oral intake of 3-10 mg, divided into several doses
As for individuals who are 12 years old and older, the recommended dosage is 6-30 mg per day taken orally, also divided into multiple doses



 

Media Gallary

References

https://www.ncbi.nlm.nih.gov/books/NBK470460/

Riboflavin Deficiency

Updated : February 14, 2024




The body requires riboflavin, often known as vitamin B2, which is water-soluble and heat-stable, to convert proteins, carbs, and lipids into glucose for energy. This vitamin not only increases energy but also serves as an antioxidant for immune function, smooth skin, and strong hair.

When there is a riboflavin deficiency, the body is unable to metabolize macronutrients such as lipids, proteins, and carbs for maintenance. For healthy growth, lactation, physical ability, and reproduction, riboflavin is required.

This activity discusses the role of the interprofessional team in enhancing care for individuals with this condition and exhibits the examination and therapy of riboflavin insufficiency.

Objectives:

  • Become familiar with the causes of riboflavin insufficiency.
  • Describe the evaluation of a riboflavin-deficient patient.
  • List the remedies for riboflavin insufficiency in brief.
  • To improve the provision of care for those with riboflavin deficiency, discuss the significance of better care coordination among the interprofessional team members. This will help patients understand how important riboflavin is for healthy development, milk production, physical ability, and reproductive capacity.

The body uses the heat-stable and water-soluble vitamin riboflavin, often known as vitamin B2, to convert lipids, proteins, and carbs into energy using glucose. Riboflavin not only increases energy but also serves as an antioxidant for immune function, hair health, and skin. The coenzymes FMN (flavin mononucleotide) and FAD (flavin adenine dinucleotide) enable these effects to take place (FAD).

The body cannot metabolize and maintain macronutrients like proteins, carbohydrates, and lipids without enough riboflavin. It is crucial to obtain the majority of riboflavin from dietary sources since the body can absorb the majority of nutrients from the diet with a healthy digestive system. The yellow-green, fluorescent pigment in riboflavin causes urine to become yellow, a sign that the body is absorbing it.

Niacin, which stimulates vitamin B6, is produced when tryptophan is transformed into riboflavin. Anemia, cataracts, migraines, and thyroid dysfunction are a few avoidable disorders that can be treated with enough riboflavin. For healthy growth, lactating, physical ability, and reproductive, riboflavin is required.

In the US, riboflavin deficiency is incredibly uncommon. The majority of riboflavin deficient cases occur in poor nations in Africa and Asia. Since the body cannot absorb much riboflavin when taking birth control pills, older persons, women, and drinkers are more prone to experience riboflavin shortage.

Many developmental problems, including cleft palate and lip, short stature, and cardiovascular illness, can be linked to riboflavin deficiency. Riboflavin insufficiency is also a problem for pregnant and nursing women, those with BVVL (Brown-Vialetto-Van Laere syndrome), and vegans.

Riboflavin deficiency has been linked to anemia, which makes people tired, according to research. The formation of RBCs and the delivery of oxygen to the cells both include riboflavin. Riboflavin intake can be improved to boost red cell formation and hemoglobin levels in the blood. The majority of hair and skin contain the protein collagen.

Hence, riboflavin is required to maintain a sufficient collagen quantity. Riboflavin supplements can potentially be used as a migraine treatment. Adult migraine headaches can be prevented by taking 400 mg of riboflavin daily, but this treatment must be taken for at least three months to be effective.

This discovery is most likely due to the fact that mitochondrial malfunction has been linked to migraines and that riboflavin is a progenitor to flavin coenzymes, which are essential for the electron transportation chain. Riboflavin supplementation has been shown to improve encephalopathy, cardiomyopathy, and muscular endurance in patients with mitochondrial complex I impairment.

The eye condition known as a cataract, which results in a hazy lens, can be prevented by consuming riboflavin supplementation. Riboflavin also benefits other eye conditions, including keratoconus and glaucoma, in addition to cataracts. To strengthen the cornea, riboflavin solutions are often applied to the sufferer’s cornea.

Additionally, blood pressure and homocysteine concentrations can be lowered by taking riboflavin supplements. Studies show that a 25% reduction in homocysteine can reduce the risk of stroke and CHD (coronary heart disease). The body produces homocysteine, an amino acid, using methionine that is acquired through dietary variables.

A lack of riboflavin in the diet or endocrine disorders can cause a deficit. Additionally, riboflavin insufficiency and other vitamin B compounds are related. Foods, including milk products, grains, meats, green vegetables, and eggs, all naturally contain riboflavin. Riboflavin, the primary antioxidant, and glutathione both function.

Due to the fact that free radicals can result in the development of numerous diseases, glutathione acts to eliminate them and cleanse the liver. Additionally, hemodialysis, alcoholism, liver disease, and chronic diarrhea can all contribute to riboflavin insufficiency.

vitamin b2 

Supplementing with riboflavin is recommended for adults experiencing syndromes caused by riboflavin deficiency
the appropriate dosage is 6-30 mg per day, taken orally and divided into multiple doses



vitamin b2 

The suggested dosage for children aged 3 to 12 years is a daily oral intake of 3-10 mg, divided into several doses
As for individuals who are 12 years old and older, the recommended dosage is 6-30 mg per day taken orally, also divided into multiple doses



https://www.ncbi.nlm.nih.gov/books/NBK470460/

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