Salivary gland neoplasms are abnormal cells growing in the salivary gland or in the ducts that drain the glands. They can be present in different locations and have different histologies, including the sublingual, parotid, minor salivary glands and submandibular. 80% of neoplasms are benign, although their tendency to recur or develop into malignant tumors varies.
Epidemiology
With a male-to-female ratio of 1:2 overall and 1:3 for benign tumors, salivary gland neoplasms more frequently affect women. Less than 5% of occurrences of salivary gland tumors occur in children, and most of these tumors tend to be benign and vascular. The equitable distribution of benign and malignant neoplasms makes up 10 to 15% of all salivary gland tumors in the submandibular gland.
Pleomorphic adenoma makes up 36% of all submandibular tumors and is the most frequent benign submandibular tumor.9.5% to 14.7% of all salivary gland tumors are minor salivary gland tumors, with the palate being the most often affected area. The prevalence of benign and malignant tumors is comparable. Pleomorphic, cystic, and canalicular adenomas are the three most typical benign small salivary gland tumors.
Anatomy
Pathophysiology
Salivary gland neoplasms have variable morphology and are considered to develop from the same stem cell pathways as healthy salivary gland tissues.
The excretory duct basal cells inevitably lead to the intercalated ducts, which subsequently give rise to the acinar units and striated ducts. The excretory duct basal cells and intercalated duct progenitor cells are capable of tumor formation and cellular division.
Etiology
Although the exact cause of salivary tumors is unspecified, smoking, radiation, trauma, genetics, and viruses have all been implicated. Salivary gland malignancies have been related in studies to former radiation exposure, with pleomorphic adenomas accounting for 50% of radiation-induced tumors.
Even though consuming alcohol and smoking do not enhance the incidence of various salivary cancers, studies have shown a high correlation between tobacco use and Warthin’s tumor. Ductal papilloma is thought to develop due to oral trauma and is typically observed on the mouth, tongue, lower lip, and palate.
Genetics
Prognostic Factors
The outcome of benign salivary gland tumors varies greatly depending on the tumor histology, with tumor progression and recurrence rates.
Pleomorphic Adenoma has been recorded in 1-5% of patients 7 to 10 years after initial treatment, most likely due to inadequate excision, capsule rupture, pseudopodia presence, and satellite lesions.
Salivary gland neoplasms are abnormal cells growing in the salivary gland or in the ducts that drain the glands. They can be present in different locations and have different histologies, including the sublingual, parotid, minor salivary glands and submandibular. 80% of neoplasms are benign, although their tendency to recur or develop into malignant tumors varies.
With a male-to-female ratio of 1:2 overall and 1:3 for benign tumors, salivary gland neoplasms more frequently affect women. Less than 5% of occurrences of salivary gland tumors occur in children, and most of these tumors tend to be benign and vascular. The equitable distribution of benign and malignant neoplasms makes up 10 to 15% of all salivary gland tumors in the submandibular gland.
Pleomorphic adenoma makes up 36% of all submandibular tumors and is the most frequent benign submandibular tumor.9.5% to 14.7% of all salivary gland tumors are minor salivary gland tumors, with the palate being the most often affected area. The prevalence of benign and malignant tumors is comparable. Pleomorphic, cystic, and canalicular adenomas are the three most typical benign small salivary gland tumors.
Salivary gland neoplasms have variable morphology and are considered to develop from the same stem cell pathways as healthy salivary gland tissues.
The excretory duct basal cells inevitably lead to the intercalated ducts, which subsequently give rise to the acinar units and striated ducts. The excretory duct basal cells and intercalated duct progenitor cells are capable of tumor formation and cellular division.
Although the exact cause of salivary tumors is unspecified, smoking, radiation, trauma, genetics, and viruses have all been implicated. Salivary gland malignancies have been related in studies to former radiation exposure, with pleomorphic adenomas accounting for 50% of radiation-induced tumors.
Even though consuming alcohol and smoking do not enhance the incidence of various salivary cancers, studies have shown a high correlation between tobacco use and Warthin’s tumor. Ductal papilloma is thought to develop due to oral trauma and is typically observed on the mouth, tongue, lower lip, and palate.
The outcome of benign salivary gland tumors varies greatly depending on the tumor histology, with tumor progression and recurrence rates.
Pleomorphic Adenoma has been recorded in 1-5% of patients 7 to 10 years after initial treatment, most likely due to inadequate excision, capsule rupture, pseudopodia presence, and satellite lesions.
on day 1 every 21 days in combination with cisplatin and cyclophosphamide.
https://www.ncbi.nlm.nih.gov/books/NBK564295/
medtigo
Salivary Gland Neoplasms
Updated :
September 2, 2022
Salivary gland neoplasms are abnormal cells growing in the salivary gland or in the ducts that drain the glands. They can be present in different locations and have different histologies, including the sublingual, parotid, minor salivary glands and submandibular. 80% of neoplasms are benign, although their tendency to recur or develop into malignant tumors varies.
With a male-to-female ratio of 1:2 overall and 1:3 for benign tumors, salivary gland neoplasms more frequently affect women. Less than 5% of occurrences of salivary gland tumors occur in children, and most of these tumors tend to be benign and vascular. The equitable distribution of benign and malignant neoplasms makes up 10 to 15% of all salivary gland tumors in the submandibular gland.
Pleomorphic adenoma makes up 36% of all submandibular tumors and is the most frequent benign submandibular tumor.9.5% to 14.7% of all salivary gland tumors are minor salivary gland tumors, with the palate being the most often affected area. The prevalence of benign and malignant tumors is comparable. Pleomorphic, cystic, and canalicular adenomas are the three most typical benign small salivary gland tumors.
Salivary gland neoplasms have variable morphology and are considered to develop from the same stem cell pathways as healthy salivary gland tissues.
The excretory duct basal cells inevitably lead to the intercalated ducts, which subsequently give rise to the acinar units and striated ducts. The excretory duct basal cells and intercalated duct progenitor cells are capable of tumor formation and cellular division.
Although the exact cause of salivary tumors is unspecified, smoking, radiation, trauma, genetics, and viruses have all been implicated. Salivary gland malignancies have been related in studies to former radiation exposure, with pleomorphic adenomas accounting for 50% of radiation-induced tumors.
Even though consuming alcohol and smoking do not enhance the incidence of various salivary cancers, studies have shown a high correlation between tobacco use and Warthin’s tumor. Ductal papilloma is thought to develop due to oral trauma and is typically observed on the mouth, tongue, lower lip, and palate.
The outcome of benign salivary gland tumors varies greatly depending on the tumor histology, with tumor progression and recurrence rates.
Pleomorphic Adenoma has been recorded in 1-5% of patients 7 to 10 years after initial treatment, most likely due to inadequate excision, capsule rupture, pseudopodia presence, and satellite lesions.
https://www.ncbi.nlm.nih.gov/books/NBK564295/
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