7.5

mg

Tablet

Orally 

every 8 hrs

increase by <5mg/kg
Maximum 90 mg/kg

1.5

mg

Tablet

Orally 

every 8 hrs

1

week

2 - 10

mg

Orally 

every 6 hrs

100

mg

Orally 

every 8 hrs

a day 1 week; titrate and increase for 50 mg orally
Maintenance dose: 200 mg-400 mg orally 8 hours a day
Do not exceed 400 mg a day

Indicated for Tonic Clonic & Complex Partial Seizures :

1

g/day

Orally 

in 4-6 divided doses; may be increased up to 2-3 g/day

50 mg orally/IV 2 times a day; dose can be adjusted b/w 25-100 mg orally/IV
When oral delivery is temporarily unfeasible, patients may use injections;
however, clinical study experience with injection is only available for 4 consecutive days of treatment
Note:
Used to treat partial-onset seizures

Maintenance dose: 800 to 1200mg /day
Maximum dose:1600mg/day

Immediate release:
Initial dose:
Tablets: 200mg orally twice a day
Oral suspension: 100mg orally every 6 hours
Increase every week by 200mg/dose divided every 6-8 hours
Maximum dose: 1600mg /day

Extended-release:
Initial dose: 200mg orally twice a day
Increase every week by 200mg/dose divided every 6-8 hours
Maximum dose: 1600mg /day

Initially:

100 - 125

mg

Orally 

at bedtime

3

days

then 100-125 mg twice a day for 3 days
following 100-125 mg thrice a day for 3 days, then 250 mg thrice to four times a day; without exceeding 2 g/day

Dose Adjustments

Dosing considerations:
Should not exceed more than 2 g/day
Do not stop abruptly, due to the chances of risk to status epilepticus
Therapeutic efficacy may take several weeks to achieve

Initial dosages of 1-3 mg/kg/day either intravenously or orally in 1 to 2 divided doses; modify as necessary to achieve a therapeutic steady-state level of 20 mg/L

Indicated for Status Epilepticus:

Administer a loading dose of 15-20 mg/kg intravenous at a rate of 25-100 mg/min; if required, repeat in 10 minutes with an additional 5-10 mg/kg; provide respiratory support once the maximal dosage is given

Indicated for Complex Partial Seizures

10-15 mg/kg IV divided 2 times a day infused over 1 hour
May be increased to 60 mg/kg daily
Maximum duration is 14 days (AS soon as possible switch to Oral)

Complex partial seizures:

10-15 mg/kg orally daily; may increase to 5-10 mg/kg once in a week
Do not exceed 60 mg/kg a day

Conversion to Monotherapy:

Reduce the dosage of a concomitant medication by about 25% every 14 days; this dosage reduction may occur when valproate therapy is started or one to two weeks after the start of valproate therapy

simple and complex absence seizures:

Initial dose: 15 mg/kg orally divided 2-4 times a day; may increase to 5-10 mg/kg
Do not exceed 60 mg/kg a day

Indicated for Seizures
Lennox-Gastaut syndrome/Dravet syndrome:
Initial dose: 2.5 mg/kg orally two times a day
Maintenance dose: After one week, may enhance to 5 mg/kg two times a day
If a 5 mg/kg two times a day dose is tolerated, and then seizure diminishment is required. when the maintenance dose is enhanced to 10 mg/kg two times a day (20 mg/kg every day), the patient may benefit, and it may achieve by an enhanced weekly increment of 2.5 mg/kg two times a day as tolerated
If further quick titration from 10 mg/kg every day to 20 mg/kg every day is warranted, the dose might be enhanced no further frequently than the every other day
20 mg/kg every day dosage administration resulted in a somewhat substantial diminishment in rates of seizures than the 10 mg/kg every day maintenance dose, Yet with enhancement in adverse reactions
Tuberous sclerosis complex:
Initial dose: 2.5 mg/kg orally two times a day
Enhanced weekly increment of 2.5 mg/kg two times a day as tolerated to the maintenance dose of 12.5 mg/kg two times a day
If further quick titration is warranted, the dose might be enhanced no further frequently than the every other day
Dose <12.5 mg/kg two times a day, effectiveness is not studied in individuals with Tuberous sclerosis complex

Indicated for Seizures
stiripentol is indicated for treating seizures related with Dravet syndrome in patients taking clobazam. However, there is no clinical data available to support the use of stiripentol as monotherapy in Dravet syndrome
The recommended dosage for stiripentol is 50 mg/kg daily, to be administered orally in two or three divided doses (16.67 mg/kg three times a day or 25 mg/kg two times a day). The maximum daily dosage should not exceed 3000 mg
If the require dosage is not feasible with the available strengths, it is permissible to the nearest possible dosage (within 50-150 mg of 50 mg/kg daily dosage). Additionally, a mixture of the two available strengths can be used to attain the prescribed dosage

Indicated to treat stereotypic episodes (intermittent) in patients with seizure activity, which are different from usual episodes of epilepsy
The recommended starting dosage is 5 mg, administered as a single spray into one nostril
Second dose (if necessary)
If the patient does not show any response to the initial dose, an extra 5 mg (1 spray) can be administered in the opposite nostril after a 10-minute interval
However, it is important to refrain from administering a second dose if the patient has trouble breathing or if excessive sedation is unusual throughout a seizure cluster episode
Maximum dose and frequency
don't use more than two doses in each single episode of seizure
dont treat more than an episode after every 3 days and not more than five episodes each month

ER: (Only for Partial-Onset Seizures)

1000 mg once daily orally
On the basis of effectiveness and tolerability, increase in 1000 mg increments every two weeks
1000–3000 mg taken orally once day as a maintenance dosage
3000 mg/day is the maximum dosage

IR:

500 mg IV/oral 2 times a day
Depending on effectiveness and tolerance, increase dosage twice daily in increments of 500 mg every two weeks
500 to 1500 mg intravenously or orally twice day for maintenance
3000 mg/day is the maximum dosage

Initial dose-Administer 900 mg orally, three to four times a day, in divided doses.
This dose can be increased by 300 mg weekly until therapeutic effects are noticed or toxic symptoms occur.
Maintenance dose- Administer 900 to 2400mg orally, three to four times daily, in divided doses.

Indicated for Seizure associated with status epilepticus poisoning or tetanus
The suggested dose is 5 to 10 ml intramuscularly

1.5

mg

Tablet

Orally 

every 8 hrs

1

week

Indicated for Tonic Clonic & Complex Partial Seizures :

750

mg/day

Orally 

in 4-6 divided doses; increased up to 500 mg-1 g/day

Age: 1 month-16 years
Wt <11 kg: 0.75-1.5 mg/kg orally every 12 hours; may be increased to 0.75-3 mg/kg
Wt 11-<20 kg: 0.5-1.25 mg/kg orally every 12 hours; may be increased to 0.5 to 2.5 mg/kg
Wt 20-<50 kg: 0.5 to 1 mg/kg orally every 12 hours; may be increased to 0.5 to 2 mg/kg
Wt ≥50 kg: 25-50 mg orally every 12 hours; may be increased to 25 to 100 mg
Age: ≥16 years
50 mg orally every 12 hours; may be increased to 25 mg-100 mg
Note:
Used to treat partial-onset seizures

Indicated for epilepsy:

<6 years of age:
Initial dose(Oral suspension):10 to 20mg/kg/day orally every 6 hours
Initial dose(Tablet): 10 to 20mg/kg/day orally every 8-12 hours
Maintenance dose:400 to 800mg/day
Maximum dose: 1000mg/day

6-12 years:
Initial dose(Oral suspension):100mg orally every 6 hours
Initial dose(Tablet): 100mg orally every 12 hours
Maintenance dose:400 to 800mg/day
Maximum dose: 1000mg/day

Over 12 years of age:
Initial dose(Oral suspension):100mg orally every 6 hours
Initial dose(Tablet): 200mg orally every 12 hours
Maintenance dose:800 to 1200mg/day
Maximum dose: 1000mg/day

Neonates (<28 days): 3 to 5 mg/kg/day in 1 to 2 divided doses intravenous or orally
Infants: 5 to 6 mg/kg/day in 1 to 2 divided doses intravenous or orally
1-5 years: 6-8 mg/kg/day in 1 to 2 divided doses intravenous or orally
6-12 years: 4-6 mg/kg/day in 1 to 2 divided doses intravenous or orally
>12 years: 1-3 mg/kg/day in 1-2 divided doses intravenous or orally, OR 50-100 mg twice or thrice a day

Infants and young children: 15-20 mg/kg intravenous given at a maximum rate of 2 mg/kg/min; Do not exceed 1000 mg/dose
<60 kg: <30 mg/min intravenous rate
When required, repeat with a 5-10 mg/kg bolus dosage after 15-30 minutes; do not exceed a total dose of 40 mg/kg

Indicated for Complex Partial Seizures

10-15 mg/kg IV divided 2 times a day infused over 1 hour
May be increased to 60 mg/kg daily
Maximum duration is 14 days (AS soon as possible switch to Oral)

Complex partial seizures:

10-15 mg/kg orally daily; may increase to 5-10 mg/kg once in a week
Do not exceed 60 mg/kg a day

Conversion to Monotherapy:

Reduce the dosage of a concomitant medication by about 25% every 14 days; this dosage reduction may occur when valproate therapy is started or one to two weeks after the start of valproate therapy

simple and complex absence seizures:

Initial dose: 15 mg/kg orally divided 2-4 times a day; may increase to 5-10 mg/kg
Do not exceed 60 mg/kg a day

Indicated for Seizures
Age >1 years
Lennox-Gastaut syndrome/Dravet syndrome:
Initial dose: 2.5 mg/kg orally two times a day
Maintenance dose: After one week, may enhance to 5 mg/kg two times a day
If a 5 mg/kg two times a day dose is tolerated, and then seizure diminishment is required. when the maintenance dose is enhanced to 10 mg/kg two times a day (20 mg/kg every day), the patient may benefit, and it may achieve by an enhanced weekly increment of 2.5 mg/kg two times a day as tolerated
If further quick titration from 10 mg/kg every day to 20 mg/kg every day is warranted, the dose might be enhanced no further frequently than the every other day
20 mg/kg every day dosage administration resulted in a somewhat substantial diminishment in rates of seizures than the 10 mg/kg every day maintenance dose, Yet with enhancement in adverse reactions
Tuberous sclerosis complex:
Initial dose: 2.5 mg/kg orally two times a day
Enhanced weekly increment of 2.5 mg/kg two times a day as tolerated to the maintenance dose of 12.5 mg/kg two times a day
If further quick titration is warranted, the dose might be enhanced no further frequently than the every other day
Dose <12.5 mg/kg two times a day, effectiveness is not studied in individuals with Tuberous sclerosis complex

Indicated for seizures
For patients who are between 6 months to less than 1 year old and weigh at least 7 kg, the recommended dosage for stiripentol is 25 mg/kg two times a day orally. The BID dosing frequency should not be exceeded to limit free water administration and prevent overexposure to the medication. For patients who weigh between 7 kg to less than 10 kg, the recommended dosage for stiripentol is also 25 mg/kg two times a day orally. The BID dosing frequency should not be exceeded to avoid overexposure to the medication
When rounding to the nearest possible dosage, it is usually recommended to stay within 50-150 mg of the recommended 50 mg/kg/day dosage. In case the exact dosage cannot be achieved with the available strengths, a combination of the two available strengths can be used to achieve the prescribed dosage. The maximum daily dosage should not exceed 3000 mg
For patients who are 1 year old or older and weigh at least 10 kg, the recommended dosage for stiripentol is 25 mg/kg two times a day orally or 16.67 mg/kg three times a day orally. The maximum daily dosage should not exceed 3000 mg

For age ≥12 years Indicated to treat stereotypic episodes (intermittent) in patients with seizure activity, which are different from usual episodes of epilepsy for children ≥12 years of age. The recommended starting dosage is 5 mg, administered as a single spray into one nostril
Second dose (if necessary)
If the patient does not show any response to the initial dose, an extra 5 mg (1 spray) can be administered in the opposite nostril after a 10-minute interval
However, it is important to refrain from administering a second dose if the patient has trouble breathing or if excessive sedation is unusual throughout a seizure cluster episode
Maximum dose and frequency
don't use more than 2 doses in each single episode of seizure
dont treat more than an episode after every 3 days and not more than 5 episodes each month

In divided doses, administer 300 to 900 mg orally three to four times daily.

Indicated for Seizure associated with status epilepticus
The suggested dose is 0.1-0.15 ml/kg, each dose every 3-6 times a day by intramuscular route