Sporothrix schenckii, often known as S. schenckii, is a dimorphic fungus which causes sporotrichosis. S. schenckii occurs as hyphae at temperatures below 37 degrees celsius and as a budding yeast at temperatures higher than of equal to 37 degree celsius. This distinctive morphology is essential for distinguishing the transition from mould to yeast.
Various strains of S. schenckii exist, and the S. schenckii complex strain is the most prevalent in Africa, Asia, and America. S. brasilienis has been discovered in Brazil and is transmitted by infected cats. S. globose and S. Mexicana have also been discovered worldwide. Sporotrichosis is transmitted through inoculation of contaminated soil, organic matter, and plants.
This illness commonly manifests as pustules and papules, which develop into ulcerated lymph nodules. Sporotrichosis is divided into disseminated, cutaneous, and pulmonary forms, with cutaneous being the most prevalent.
Immunocompromised patients, as well as those with chronic obstructive lung disease, diabetes mellitus, and alcoholic tendencies, are susceptible to disseminated illness. To prevent illness, it is wise to wear gloves and long sleeves as a precautionary measure when working with soil. Fungal cultures are the best diagnostic tool for sporotrichosis, and Itraconazole is the first-line treatment.
Epidemiology
Most cases of Sporotrichosis occur in tropical and subtropical regions of the Americas. Sporotrichosis is particularly prevalent in the river basins and southern coastal regions of North America.
There is an elevated risk of infection among miners, horticulturists, miners, farmers, armadillo hunters, and rose gardeners. Patients with symptoms should be questioned about their occupations. S. schenckii is isolable from soil, plants, and plant-based products.
Infection can also result from animal transmissions or zoonotic transmissions caused due to scratching or biting from infected cats. In Rio de Janeiro, 4,669 cases have been reported due to interactions with cats.
Sporotrichosis is a condition that can affect anyone, regardless of gender or age, due to occupational exposure. In Uruguay, this condition is more prevalent among males and armadillo hunters, whereas in India, females are more susceptible because to their larger participation in agricultural labor.
Anatomy
Pathophysiology
S. schenckii is a dimorphic fungus that exists as hyphae at temperatures below 37 degrees Celsius and as yeast at temperatures above 37 degrees Celsius. S. schenckii is found on marine animals, soil moss, wood and decaying vegetation.
A virulence factor is an organismal characteristic that promotes microbial development.
Melanin, ergosterol peroxide, and thermotolerance are virulence factors for S. schenkii. During phagocytosis, the fungus produces ergosterol peroxide to prevent the formation of reactive oxygen species.
Etiology
Medical student Benjamin Schenx initially isolated S. schenckii in 1896 at John Hopkins Hospital.
Sporotrichosis was once believed to be caused by a single organism, but it is now known to contain multiple species, such as S. brasilienis, S. globosa, and S. Mexicana; hence, it has been termed S. schenckii sent lato, or S. schenckii complex.
Sporotrichosis has been documented in the majority of mammalian species, including dogs, cats, armadillos, and rats.
(Off-Label)
Also indicated for Cutaneous and Lymphocutaneous
500 mg orally each day every 12 hours for 2-6 weeks
After the resolution of lesions, additional treatment can be done for more than 2-4 weeks
A total of 3-6 months is required for lesion resolution
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References
https://www.ncbi.nlm.nih.gov/books/NBK532255/
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Sporothrix schenckii, often known as S. schenckii, is a dimorphic fungus which causes sporotrichosis. S. schenckii occurs as hyphae at temperatures below 37 degrees celsius and as a budding yeast at temperatures higher than of equal to 37 degree celsius. This distinctive morphology is essential for distinguishing the transition from mould to yeast.
Various strains of S. schenckii exist, and the S. schenckii complex strain is the most prevalent in Africa, Asia, and America. S. brasilienis has been discovered in Brazil and is transmitted by infected cats. S. globose and S. Mexicana have also been discovered worldwide. Sporotrichosis is transmitted through inoculation of contaminated soil, organic matter, and plants.
This illness commonly manifests as pustules and papules, which develop into ulcerated lymph nodules. Sporotrichosis is divided into disseminated, cutaneous, and pulmonary forms, with cutaneous being the most prevalent.
Immunocompromised patients, as well as those with chronic obstructive lung disease, diabetes mellitus, and alcoholic tendencies, are susceptible to disseminated illness. To prevent illness, it is wise to wear gloves and long sleeves as a precautionary measure when working with soil. Fungal cultures are the best diagnostic tool for sporotrichosis, and Itraconazole is the first-line treatment.
Most cases of Sporotrichosis occur in tropical and subtropical regions of the Americas. Sporotrichosis is particularly prevalent in the river basins and southern coastal regions of North America.
There is an elevated risk of infection among miners, horticulturists, miners, farmers, armadillo hunters, and rose gardeners. Patients with symptoms should be questioned about their occupations. S. schenckii is isolable from soil, plants, and plant-based products.
Infection can also result from animal transmissions or zoonotic transmissions caused due to scratching or biting from infected cats. In Rio de Janeiro, 4,669 cases have been reported due to interactions with cats.
Sporotrichosis is a condition that can affect anyone, regardless of gender or age, due to occupational exposure. In Uruguay, this condition is more prevalent among males and armadillo hunters, whereas in India, females are more susceptible because to their larger participation in agricultural labor.
S. schenckii is a dimorphic fungus that exists as hyphae at temperatures below 37 degrees Celsius and as yeast at temperatures above 37 degrees Celsius. S. schenckii is found on marine animals, soil moss, wood and decaying vegetation.
A virulence factor is an organismal characteristic that promotes microbial development.
Melanin, ergosterol peroxide, and thermotolerance are virulence factors for S. schenkii. During phagocytosis, the fungus produces ergosterol peroxide to prevent the formation of reactive oxygen species.
Medical student Benjamin Schenx initially isolated S. schenckii in 1896 at John Hopkins Hospital.
Sporotrichosis was once believed to be caused by a single organism, but it is now known to contain multiple species, such as S. brasilienis, S. globosa, and S. Mexicana; hence, it has been termed S. schenckii sent lato, or S. schenckii complex.
Sporotrichosis has been documented in the majority of mammalian species, including dogs, cats, armadillos, and rats.
(Off-Label)
Also indicated for Cutaneous and Lymphocutaneous
500 mg orally each day every 12 hours for 2-6 weeks
After the resolution of lesions, additional treatment can be done for more than 2-4 weeks
A total of 3-6 months is required for lesion resolution
https://www.ncbi.nlm.nih.gov/books/NBK532255/
medtigo
Sporotrichosis
Updated :
August 30, 2023
Sporothrix schenckii, often known as S. schenckii, is a dimorphic fungus which causes sporotrichosis. S. schenckii occurs as hyphae at temperatures below 37 degrees celsius and as a budding yeast at temperatures higher than of equal to 37 degree celsius. This distinctive morphology is essential for distinguishing the transition from mould to yeast.
Various strains of S. schenckii exist, and the S. schenckii complex strain is the most prevalent in Africa, Asia, and America. S. brasilienis has been discovered in Brazil and is transmitted by infected cats. S. globose and S. Mexicana have also been discovered worldwide. Sporotrichosis is transmitted through inoculation of contaminated soil, organic matter, and plants.
This illness commonly manifests as pustules and papules, which develop into ulcerated lymph nodules. Sporotrichosis is divided into disseminated, cutaneous, and pulmonary forms, with cutaneous being the most prevalent.
Immunocompromised patients, as well as those with chronic obstructive lung disease, diabetes mellitus, and alcoholic tendencies, are susceptible to disseminated illness. To prevent illness, it is wise to wear gloves and long sleeves as a precautionary measure when working with soil. Fungal cultures are the best diagnostic tool for sporotrichosis, and Itraconazole is the first-line treatment.
Most cases of Sporotrichosis occur in tropical and subtropical regions of the Americas. Sporotrichosis is particularly prevalent in the river basins and southern coastal regions of North America.
There is an elevated risk of infection among miners, horticulturists, miners, farmers, armadillo hunters, and rose gardeners. Patients with symptoms should be questioned about their occupations. S. schenckii is isolable from soil, plants, and plant-based products.
Infection can also result from animal transmissions or zoonotic transmissions caused due to scratching or biting from infected cats. In Rio de Janeiro, 4,669 cases have been reported due to interactions with cats.
Sporotrichosis is a condition that can affect anyone, regardless of gender or age, due to occupational exposure. In Uruguay, this condition is more prevalent among males and armadillo hunters, whereas in India, females are more susceptible because to their larger participation in agricultural labor.
S. schenckii is a dimorphic fungus that exists as hyphae at temperatures below 37 degrees Celsius and as yeast at temperatures above 37 degrees Celsius. S. schenckii is found on marine animals, soil moss, wood and decaying vegetation.
A virulence factor is an organismal characteristic that promotes microbial development.
Melanin, ergosterol peroxide, and thermotolerance are virulence factors for S. schenkii. During phagocytosis, the fungus produces ergosterol peroxide to prevent the formation of reactive oxygen species.
Medical student Benjamin Schenx initially isolated S. schenckii in 1896 at John Hopkins Hospital.
Sporotrichosis was once believed to be caused by a single organism, but it is now known to contain multiple species, such as S. brasilienis, S. globosa, and S. Mexicana; hence, it has been termed S. schenckii sent lato, or S. schenckii complex.
Sporotrichosis has been documented in the majority of mammalian species, including dogs, cats, armadillos, and rats.
https://www.ncbi.nlm.nih.gov/books/NBK532255/
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