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Stem cell therapy

Updated : August 3, 2023





Background

Stem cells are the origin point of all cells. The human body contains unspecialized stem cells. They are capable of self-renewal and developing into any cell of an organism. Both embryonic and adult cells possess stem cells.

Stem cell treatments are described as any treatment for a disease or medical condition that primarily involves the application of any viable human stem cell for autologous or allogeneic therapies, including embryonic stem cells, iPSCs, and adult stem cells.

Epidemiology

Since the first successful treatments in 1968, more than a million hematopoietic stem cell transplants (HCTs) have been performed, with roughly 50,000 performed each year globally.

Most HCTs currently treat malignant conditions, especially blood malignancies, despite being first used to treat non-malignant marrow illnesses such as primary immunological deficiencies and aplastic anemia. Given that the rationale for all HCTs was the management of malignancy, the percentage of fatalities from recurrence is alarming.

For auto and allogenic HCTs, the risk of treatment-related mortality dropped over time, but the chances of relapse increased. Treatment failure rates were generally consistent.

Anatomy

Pathophysiology

Directing stem cells to differentiate into specific cells employed in individuals to regenerate and restore tissues damaged or impacted by disease is possible.

Spinal cord injuries, multiple sclerosis, type 1 diabetes, Alzheimer’s disease, dental pulp regeneration, amyotrophic lateral sclerosis, heart disease, Parkinson’s disease, stroke, periodontal tissue regeneration, osteoarthritis, cancer, and burns are among the conditions that stem cell therapy may help.

The ability to develop stem cells into new tissue for use in transplant and regenerative medicine may exist. Understanding stem cells and their uses in transplant and regenerative medicine is still being developed.

Etiology

There are several sources of stem cell

Embryonic stem cells

These embryonic stem cells range in age from three to five days. A blastocyst, an embryo at this stage, has 150 cells. These are pluripotent stem cells, which may differentiate into any form of body cell or additional stem cells. Due to their adaptability, embryonic stem cells can be employed to replace or treat damaged tissue and organs.

Adult stem cells

Most adult tissues, including bone marrow and fat, contain a tiny amount of these stem cells. Various cell types may be created by adult stem cells. As an illustration, bone marrow stem cells could be able to produce heart or bone cells.

Perinatal stem cells

Amniotic fluid and umbilical cord blood both contain stem cells. These stem cells have the capacity to differentiate into many types of cells. The sac that surrounds and protects a growing fetus in the uterus is filled with amniotic fluid. In samples of amniotic fluid taken from pregnant women for diagnosis or treatment (a process known as amniocentesis), stem cells are discovered.

Genetics

Prognostic Factors

An overall success rate is difficult to determine. According to studies, most individuals get stem cell therapy to treat Hodgkin lymphoma that reappeared after chemotherapy.

Ninety-two percent of patients who had transplants were alive three years later. At the same time, 79% of the individuals who underwent therapy for multiple myeloma were alive even after three years with minimum complications.

Clinical History

Physical Examination

Age group

Associated comorbidity

Associated activity

Acuity of presentation

Differential Diagnoses

Laboratory Studies

Imaging Studies

Procedures

Histologic Findings

Staging

Treatment Paradigm

by Stage

by Modality

Chemotherapy

Radiation Therapy

Surgical Interventions

Hormone Therapy

Immunotherapy

Hyperthermia

Photodynamic Therapy

Stem Cell Transplant

Targeted Therapy

Palliative Care

Medication

Media Gallary

References

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6282701/

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Stem cell therapy

Updated : August 3, 2023




Stem cells are the origin point of all cells. The human body contains unspecialized stem cells. They are capable of self-renewal and developing into any cell of an organism. Both embryonic and adult cells possess stem cells.

Stem cell treatments are described as any treatment for a disease or medical condition that primarily involves the application of any viable human stem cell for autologous or allogeneic therapies, including embryonic stem cells, iPSCs, and adult stem cells.

Since the first successful treatments in 1968, more than a million hematopoietic stem cell transplants (HCTs) have been performed, with roughly 50,000 performed each year globally.

Most HCTs currently treat malignant conditions, especially blood malignancies, despite being first used to treat non-malignant marrow illnesses such as primary immunological deficiencies and aplastic anemia. Given that the rationale for all HCTs was the management of malignancy, the percentage of fatalities from recurrence is alarming.

For auto and allogenic HCTs, the risk of treatment-related mortality dropped over time, but the chances of relapse increased. Treatment failure rates were generally consistent.

Directing stem cells to differentiate into specific cells employed in individuals to regenerate and restore tissues damaged or impacted by disease is possible.

Spinal cord injuries, multiple sclerosis, type 1 diabetes, Alzheimer’s disease, dental pulp regeneration, amyotrophic lateral sclerosis, heart disease, Parkinson’s disease, stroke, periodontal tissue regeneration, osteoarthritis, cancer, and burns are among the conditions that stem cell therapy may help.

The ability to develop stem cells into new tissue for use in transplant and regenerative medicine may exist. Understanding stem cells and their uses in transplant and regenerative medicine is still being developed.

There are several sources of stem cell

Embryonic stem cells

These embryonic stem cells range in age from three to five days. A blastocyst, an embryo at this stage, has 150 cells. These are pluripotent stem cells, which may differentiate into any form of body cell or additional stem cells. Due to their adaptability, embryonic stem cells can be employed to replace or treat damaged tissue and organs.

Adult stem cells

Most adult tissues, including bone marrow and fat, contain a tiny amount of these stem cells. Various cell types may be created by adult stem cells. As an illustration, bone marrow stem cells could be able to produce heart or bone cells.

Perinatal stem cells

Amniotic fluid and umbilical cord blood both contain stem cells. These stem cells have the capacity to differentiate into many types of cells. The sac that surrounds and protects a growing fetus in the uterus is filled with amniotic fluid. In samples of amniotic fluid taken from pregnant women for diagnosis or treatment (a process known as amniocentesis), stem cells are discovered.

An overall success rate is difficult to determine. According to studies, most individuals get stem cell therapy to treat Hodgkin lymphoma that reappeared after chemotherapy.

Ninety-two percent of patients who had transplants were alive three years later. At the same time, 79% of the individuals who underwent therapy for multiple myeloma were alive even after three years with minimum complications.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6282701/

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