- March 23, 2022
- Newsletter
- 617-430-5616
Menu
Menu
Menu
Menu
Menu
Menu
Brand Name :
Xeglyze
Synonyms :
abametapir
Class :
Topical Pediculicides
Dosage Forms & Strengths
lotion (topical)
0.74%
Recommended for use in the topical treatment of head lice infestation
Apply to dry hair in a quantity sufficient to completely cover the hair and scalp
Use as part of a comprehensive lice management programme:
Wash any recently used items, caps, used bedding, and towels in hot water or dry clean them
Wash personal care products in hot water, such as combs, brushes, and hair clips
Dead lice and nits should be removed with a fine-tooth comb or specialised nit comb
lotion (topical)
0.74%
Age: ≥6 months
Recommended for use in the topical treatment of head lice infestation
Apply to dry hair in a quantity sufficient to completely cover the hair and scalp
Use as part of a comprehensive lice management programme:
Wash any recently used items, caps, used bedding, and towels in hot water or dry clean them
Wash personal care products in hot water, such as combs, brushes, and hair clips
Dead lice and nits should be removed with a fine-tooth comb or specialised nit comb
Refer to the adult dosing regimen
may enhance the serum concentration of abametapir
It may enhance the effect when combined with lonafarnib by affecting CYP3A4 metabolism
when both drugs are combined, there may be an increased effect of nilotinib by affecting hepatic or intestinal enzyme cyp3a4 metabolism
may increase the serum concentration of epinastine when combined
may increase the serum concentration when combined with each other
It may enhance the effect when combined with pemigatinib by affecting CYP3A4 metabolism
It may enhance the effect when combined with sufentanil by affecting CYP3A4 metabolism
It may enhance the level when combined with efavirenz by affecting CYP3A4 metabolism
It may enhance the levels when combined with tamsulosin by affecting CYP3A4 metabolism
cyclophosphamide effect of action increased by affecting enzyme CYP3A4 metabolism.
when both drugs are combined, there may be an increased effect of cabozantinib by affecting hepatic or intestinal enzyme cyp3a4 metabolism
when both drugs are combined, there may be an increasing effect of alpelisib by affecting hepatic or intestinal enzyme cyp3a4 metabolism
abametapir, when interacts with brentuximab vedotin, will increase its effect by altering the intestinal/hepatic metabolism of CYP3A4 enzyme the drugs containing substrates of CYP3A4 should be avoided during the medication.
when both drugs are combined, there may be an increased level of serum concentration of erlotinib
the effect of abametapir is increased by lorlatinib, by altering intestinal or hepatic CYP3A4 enzyme metabolism
when both drugs are combined, there may be an increased level or effect of romidepsin by affecting hepatic or intestinal enzyme cyp3a4 metabolism
abametapir increases the effect of ixazomib by altering intestinal/hepatic CYP3A4 enzyme metabolism
abametapir increases the effect of lapatinib by altering the intestinal or hepatic CYP3A4 enzyme metabolism
abametapir increases the effect of fedratinib by altering the intestinal/hepatic CYP3A4 enzyme metabolism
abametapir increases the effect of gefitinib by altering the intestinal/ hepatic CYP3A4 enzyme metabolism
abametapir increases the effect or level of midostaurin by altering the CYP3A4 enzyme metabolism
abametapir increases the effect or level of midostaurin by altering the CYP3A4 enzyme metabolism
it increases the effect or level of palbociclib by altering the intestinal or hepatic CYP3A4 enzyme metabolism
it increases the effect or level of ruxolitinib by altering the intestinal or hepatic CYP3A4 enzyme metabolism
it increases the effect or level of dronabinol by altering the intestinal or hepatic metabolism
when both drugs are combined, there may be an increased risk of adverse effects
when both drugs are combined, there may be an increased risk of adverse effects
may increase the level by affecting hepatic enzyme CYP3A4 metabolism
may increase the level by affecting the hepatic enzyme CYP3A4 metabolism
it enhances by affecting the hepatic enzyme CYP2B6 metabolism
may increase the level of zonisamide by affecting the hepatic enzyme CYP3A4 metabolism
may increase the level by affecting hepatic enzyme CYP3A4 metabolism
relugolix/estradiol/norethindrone
it enhances by affecting the hepatic enzyme CYP3A4 metabolism
abametapir affect the hepatic enzyme CYP1A2 metabolism to increase the level or effect of melatonin
It may enhance the levels when combined with tamsulosin by affecting CYP3A4 metabolism
The co-administration of abametapir has the potential to elevate the concentration serum of netupitant
abametapir with mibefradil may result in an enhance in the concentration serum of mibefradil
Combining antipyrine with abametapir may lead to an elevation in the concentration serum of antipyrine
when both drugs are combined, there may be an increased the serum concentration of paclitaxel
it may enhance the serum concentration when combined with azelastine
may increase the serum concentration when it is combined
anagrelide: they may increase the antiplatelet effect of antiparasitic agents
zanubrutinib: they may increase the antiplatelet effect of antiparasitic agents
Actions and spectrum:
abametapir is a topical insecticide used for the treatment of head lice infestations. It belongs to the class of metalloproteinase inhibitors. abametapir works by blocking an essential metalloproteinase enzyme in the head lice, leading to their death.
abametapir has a broad spectrum of activity against head lice, including those that have developed resistance to other treatments. It is also effective against both adult lice and their eggs.
Frequency defined
1-10%
Hair color changes (1%)
Eye irritation (1.2-1.7%)
Contact dermatitis (1.7%)
Vomiting (1.7%)
Skin burning (2.6%)
edema/Scalp erythema (3.2%)
Rash (3.2%)
Erythema (4%)
Contraindication/Caution:
Contraindication:
abametapir is contraindicated in individuals who have had an allergic reaction to abametapir or any of its components. There are no other known contraindications for abametapir.
Caution:
Comorbidities:
abametapir is a topical insecticide used to treat head lice infestations in patients aged six months and older. There are no known comorbidities associated with abametapir use. However, caution should be exercised in patients with known hypersensitivity or allergy to any of the ingredients in the product. Additionally, patients with open wounds, broken or inflamed skin, or scalp conditions such as psoriasis should avoid using abametapir until these conditions have resolved.
Pregnancy consideration: US FDA pregnancy category: Not assigned
Lactation: It is also not known if abametapir passes into breast milk
Pregnancy category:
Pharmacology:
abametapir is a topical insecticide that is used to treat and prevent head lice infestations in adults and children. The active ingredient in abametapir, called abametapir benzylate, acts by disrupting the nervous system of the lice, leading to paralysis and death. abametapir has low systemic absorption, which means that it stays mostly on the skin and is not expected to have significant effects on the body.
abametapir benzylate belongs to a class of compounds called metalloprotease inhibitors. It works by inhibiting an enzyme called metalloprotease in the lice, which is essential for their survival. Without this enzyme, the lice are unable to maintain their outer protective layer, leading to dehydration, paralysis, and death.
The pharmacology of abametapir is largely limited to its topical action on the skin, where it is applied as a lotion. The drug is not absorbed systemically, and there is no evidence of significant metabolism or elimination in humans.
Pharmacodynamics:
abametapir is an insecticide that works by disrupting the insect’s nervous system. Specifically, it inhibits acetylcholinesterase, an enzyme that breaks down the neurotransmitter acetylcholine. By blocking this enzyme, acetylcholine builds up in the insect’s nervous system, leading to overstimulation and paralysis.
In humans, abametapir is used topically as a pediculicide to treat head lice infestations. Its mechanism of action against head lice is not fully known, but it is thought to disrupt the insect’s nervous system in a similar way as it does in insects.
abametapir is not absorbed through the skin and is only effective when used as directed on the scalp and hair. It has no systemic effects in humans.
Pharmacokinetics:
Absorption
abametapir is applied topically to the hair and scalp. The drug is not well absorbed through the skin, and only minimal amounts are expected to enter the systemic circulation.
Distribution
The distribution of abametapir after topical application is not well characterized.
Metabolism
The metabolism of abametapir has not been extensively studied, but it is expected to undergo hepatic metabolism after systemic absorption.
Elimination and excretion
The excretion of abametapir has not been well characterized, but it is expected to be primarily eliminated in the feces after hepatic metabolism.
Administration:
abametapir is administered topically as a lotion. It should be applied to dry hair and scalp until the entire scalp and hair are completely coated with the lotion. The lotion should be left on for at least 10 minutes before rinsing thoroughly with water.
The recommended dose for children 6 months of age and older is 25 mL (one bottle) of the lotion. The lotion should not be used more than once every 7 days.
Patient information leaflet
Generic Name: abametapir
Pronounced: (ab-a-MEH-ta-peer)
Why do we use abametapir?
abametapir is a topical insecticide used to treat head lice infestation in adults and children who are 6 months of age and older. It works by inhibiting the activity of an enzyme called acetylcholinesterase, which is important for the proper functioning of the nervous system of head lice. abametapir causes paralysis and death of the lice, thus treating the infestation. It is usually applied to both the scalp and hair, left on for a certain period of time, and then washed off.
ADVERTISEMENT
Founded in 2014, medtigo is committed to providing high-quality, friendly physicians, transparent pricing, and a focus on building relationships and a lifestyle brand for medical professionals nationwide.
USA – BOSTON
60 Roberts Drive, Suite 313
North Adams, MA 01247
INDIA – PUNE
7, Shree Krishna, 2nd Floor, Opp Kiosk Koffee, Shirole Lane, Off FC Road, Pune 411004, Maharashtra
Founded in 2014, medtigo is committed to providing high-quality, friendly physicians, transparent pricing, and a focus on building relationships and a lifestyle brand for medical professionals nationwide.
