acebrophylline

Action and Spectrum

Actions and Spectrum 

acebrophylline acts as a bronchodilator, which means it helps to expand the airways in the lungs. This effect is particularly useful in the management of chronic obstructive pulmonary disease (COPD), bronchial asthma, and other conditions characterized by bronchoconstriction or airway narrowing. It promotes better airflow and easier breathing.

Drug Interaction

Adverse Reaction

Frequency not defined  

Nausea 

Vomiting 

Abdominal distension  

Red spots or bumps  

Breathing problems  

Esophageal bleeding 

Drowsiness 

Heartburn 

Loss of appetite 

Rash 

Itching  

Constipation 

Nasal inflammation 

Black Box Warning

Black Box Warning 

None 

Contraindication / Caution

Contraindication/Caution: 

Contraindication: 

• acebrophylline should not be used in individuals who have a known hypersensitivity or allergy to its components. 
• acebrophylline is contraindicated in individuals with active peptic ulcers. 

Caution: 

• acebrophylline should be used with caution in individuals with a history of seizure disorders. 
• Caution is advised while using acebrophylline in patients with a history of heart disease or arrhythmias. 

Pregnancy / Lactation

Pregnancy consideration: 

Pregnancy category: N/A 

Lactation: Excretion into human milk is unknown  

Pregnancy Categories:         

Category A: well-controlled and Satisfactory studies show no risk to the fetus in the first or later trimester. 

<b>Category B: there was no evidence of risk to the fetus in animal studies, and there were not enough studies on pregnant women.  

Category C: there was evidence of risk of adverse effects in animal reproduction studies, and no adequate evidence in human studies must take care of potential risks in pregnant women. 

Category D: adequate data with sufficient evidence of human fetal risk from various platforms, but despite the potential risk, and used only in emergency cases for potential benefits. 

Category X: Drugs listed in this category outweigh the risks over benefits. Hence these categories of drugs need to be avoided by pregnant women. 

Category N: There is no data available for the drug under this category. 

Pharmacology

Pharmacology  

acebrophylline has broncho-dilatory properties and works by relaxing the smooth muscles in the airways, leading to bronchial dilation and increased airflow. 

Theophylline achieves its bronchodilator effect through several mechanisms, including phosphodiesterase inhibition, adenosine receptor antagonism, and stimulation of the release of epinephrine and norepinephrine. 

Pharmacodynamics 

acebrophylline is a mucolytic agent which acts by reducing the viscosity of mucus in the respiratory tract. Thinner mucus is easier to clear from the airways, making it effective in conditions such as mucus production or thickened mucus. 

Pharmacokinetics 

Absorption   

acebrophylline is well-absorbed from the gastrointestinal tract after oral intake. 

Distribution 

acebrophylline is distributed throughout the body. 

Metabolism 

acebrophylline undergoes metabolism in the liver. 

Elimination and excretion 

acebrophylline is excreted through the kidneys.

Adminstartion

Administration 

acebrophylline is taken orally in the form of tablets and syrup.

Patient Information Leaflet

Patient information leaflet 

Generic Name: acebrophylline 

Why do we use acebrophylline? 

acebrophylline is used in individuals with COPD, a chronic lung disease that includes conditions like chronic bronchitis and emphysema. acebrophylline is used as adjunct therapy in the management of bronchial asthma.