How Far Is Too Far? The Ethics of Mini Brain Research
December 11, 2025
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Brand Name :
AB Phylline, Ascovent, Macphylline, Bigbro
Synonyms :
acebrophylline
Class :
Mucolytic and Bronchodilator agents
Brand Name :
AB Phylline, Ascovent, Macphylline, Bigbro
Synonyms :
acebrophylline
Class :
Mucolytic and Bronchodilator agents
Dosage Forms & Strengths
Tablet
100 mg
Syrup
50mg/5ml
Chronic Obstructive Pulmonary Disease (COPD)
Take a dose of 100 mg orally two times daily
Take a dose of 100 mg orally two times daily
Dosage Forms & Strengths
Tablet
100 mg
Syrup
50mg/5ml
Chronic Obstructive Pulmonary Disease (COPD)
For <2 years old:
Take a dose of 2.5 ml orally two times daily
For 2 to 5 years old:
Take a dose of 2.5 ml orally three times daily
For >5 years old:
Take a dose of 5 ml orally two times daily
Refer to adult dosing
Actions and Spectrum
acebrophylline acts as a bronchodilator, which means it helps to expand the airways in the lungs. This effect is particularly useful in the management of chronic obstructive pulmonary disease (COPD), bronchial asthma, and other conditions characterized by bronchoconstriction or airway narrowing. It promotes better airflow and easier breathing.
Frequency not defined
Nausea
Vomiting
Red spots or bumps
Breathing problems
Esophageal bleeding
Drowsiness
Heartburn
Loss of appetite
Rash
Itching
Constipation
Nasal inflammation
Black Box Warning
None
Contraindication/Caution:
Contraindication:
Caution:
Pregnancy consideration:
Pregnancy category: N/A
Lactation: Excretion into human milk is unknown
Pregnancy Categories:
Category A: well-controlled and Satisfactory studies show no risk to the fetus in the first or later trimester.
<b>Category B: there was no evidence of risk to the fetus in animal studies, and there were not enough studies on pregnant women.
Category C: there was evidence of risk of adverse effects in animal reproduction studies, and no adequate evidence in human studies must take care of potential risks in pregnant women.
Category D: adequate data with sufficient evidence of human fetal risk from various platforms, but despite the potential risk, and used only in emergency cases for potential benefits.
Category X: Drugs listed in this category outweigh the risks over benefits. Hence these categories of drugs need to be avoided by pregnant women.
Category N: There is no data available for the drug under this category.
Pharmacology
acebrophylline has broncho-dilatory properties and works by relaxing the smooth muscles in the airways, leading to bronchial dilation and increased airflow.
Theophylline achieves its bronchodilator effect through several mechanisms, including phosphodiesterase inhibition, adenosine receptor antagonism, and stimulation of the release of epinephrine and norepinephrine.
Pharmacodynamics
acebrophylline is a mucolytic agent which acts by reducing the viscosity of mucus in the respiratory tract. Thinner mucus is easier to clear from the airways, making it effective in conditions such as mucus production or thickened mucus.
Pharmacokinetics
Absorption
acebrophylline is well-absorbed from the gastrointestinal tract after oral intake.
Distribution
acebrophylline is distributed throughout the body.
Metabolism
acebrophylline undergoes metabolism in the liver.
Elimination and excretion
acebrophylline is excreted through the kidneys.
Administration
acebrophylline is taken orally in the form of tablets and syrup.
Patient information leaflet
Generic Name: acebrophylline
Why do we use acebrophylline?
acebrophylline is used in individuals with COPD, a chronic lung disease that includes conditions like chronic bronchitis and emphysema. acebrophylline is used as adjunct therapy in the management of bronchial asthma.
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