- March 15, 2022
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Brand Name :
Aceclan,Aceclofar,Aflamil,Bristaflam,Clanza,Zerodol
Synonyms :
aceclofenac
Class :
Analgesic, Nonsteroidal Anti-inflammatory Drug
Dosage Forms & Strengths
Oral Tablet
100mg
Sustained release tablet
200mg
Safety and efficacy not established
Refer adult dosing
may enhance the risk of gastrointestinal irritation when combined with aceclofenac
may increase the risk or severity of hypertension when combined
may diminish the excretion rate of amantadine
may increase the anticoagulation effect when combined
may enhance the risk of adverse effects when combined with aceclofenac
may enhance the risk of hypoglycemia when combined
may increase the risk of adverse effects when combined
When suprofen is taken in conjunction with aceclofenac, there is a potential for an enhance in the seriousness of adverse events
it decreases the rate of elimination of pidotimod acemetacin
may reduce the therapeutic effect
may reduce the therapeutic effect
may reduce the therapeutic effect
it may diminish the excretion rate when combined with permethrin, resulting in an enhanced serum level
By competing with acidic (anionic) drugs for renal clearance, aceclofenac will raise the amount of probenecid
The combination of antipyrine with aceclofenac may elevate the seriousness of adverse events
The seriousness of nephrotoxic effect is enhanced when aceclofenac is used in conjunction with cefotiam
it may diminish the excretion rate when combined with gadofosveset, resulting in an enhanced serum level
When aminophenazone is taken together with acelofenac, there is a potential for an elevated risk or enhanced seriousness of adverse events
aceclofenac Might lead to a reduction in the rate of excretion of triethylenetetramine, potentially leading to elevated levels of serum
Combining xamoterol with aceclofenac may elevate the risk/seriousness of hypertension
meticrane has the potential to enhance the rate of excretion of aceclofenac; this can potentially lead to decreased levels of serum, possibly diminishing its effectiveness
levobetaxolol's antihypertensive properties might be reduced by aceclofenac
It may enhance the risk of bleeding when combined with nimesulide
aceclofenac has the potential to reduce the rate of excretion of idebenone, leading to an elevation in levels of serum
It may enhance the risk of adverse effects when combined with Glycopeptides
It may enhance the risk of adverse effects when combined with Glycopeptides
When loracarbef is used together with acelofenac, the risk or seriousness of nephrotoxicity is enhanced
When acelofenac is used together with hexoprenaline, the potential for hypertension to occur may be elevated
SSRIs increase the antiplatelet effect of NSAIDs
choline magnesium trisalicylate
may enhance the adverse/toxic effect of salicylates
it may enhance the serum potassium levels
may decrease the levels of serum potassium
it may enhance the serum potassium levels
glycopyrrolate inhaled and formoterol
it enhances the serum potassium levels
may increase the risk or severity of hypertension when combined
may enhance the risk or severity of hypertension when combined
may enhance the risk or severity of hypertension when combined
may increase the risk or severity of hypertension when combined
anticoagulation is increased by aceclofenac and decreased by mistletoe. The interaction's effect is unclear; exercise caution
may increase the levels of serum concentration
may increase the levels of serum concentration
may increase the levels of serum concentration
may increase the levels of serum concentration
may increase the levels of serum concentration
may increase the anticoagulation when combined with ginkgo biloba
may increase the anticoagulation effect when combined
may increase the risk of hypertension when combined
Increased serum concentration level by competitive plasma protein binding.
when both drugs are combined, there may be an increased effect of aceclofenac by acidic (anionic) drug competition for renal tubular clearance
Actions and Spectrum:
The mechanism of action of aceclofenac involves inhibiting the cyclooxygenase (COX) enzyme, which is responsible for the production of prostaglandins. aceclofenac selectively inhibits the COX-2 isoform of the enzyme, which is the primary source of prostaglandins involved in inflammation and pain.
By inhibiting the COX-2 enzyme, aceclofenac reduces the production of prostaglandins, thereby reducing pain and inflammation. aceclofenac has a broad spectrum of activity and is effective in treating various conditions such as rheumatoid arthritis, osteoarthritis, ankylosing spondylitis, and other painful inflammatory conditions. It also treats acute pain, including postoperative pain, dental pain, and dysmenorrhea (painful menstrual periods).
Frequency not defined
Constipation
Nausea
Skin rash
Visual Disturbance
Flushing
Abdominal pain
Diarrhoea
Vomiting
Dizziness
Flatulence
Stomach Pain
Contraindications/caution:
Contraindications:
Caution:
Pregnancy consideration: aceclofenac should be avoided during pregnancy as it can harm the developing fetus.
Lactation: Excretion of the drug in human breast milk is unknown
Pregnancy category:
Category A: well-controlled and Satisfactory studies show no risk to the fetus in the first or later trimester.
Category B: there was no evidence of risk to the fetus in animal studies, and there were not enough studies on pregnant women.
Category C: there was evidence of risk of adverse effects in animal reproduction studies, and no adequate evidence in human studies must take care of potential risks in pregnant women.
Category D: adequate data with sufficient evidence of human fetal risk from various platforms, but despite the potential risk, and used only in emergency cases for potential benefits.
Category X: Drugs listed in this category outweigh the risks over benefits. Hence these categories of drugs need to be avoided by pregnant women.
Category N: There is no data available for the drug under this category
Pharmacology:
aceclofenac is a nonsteroidal anti-inflammatory drug (NSAID) that relieves pain and inflammation. Its pharmacology involves multiple mechanisms of action.
Pharmacodynamics:
aceclofenac affects various physiological systems, including the musculoskeletal, immune, and nervous systems. In the musculoskeletal system, aceclofenac reduces pain and inflammation associated with osteoarthritis, rheumatoid arthritis, and ankylosing spondylitis. In the immune system, aceclofenac has anti-inflammatory effects that help reduce the activity of immune cells involved in inflammation. In the nervous system, aceclofenac can reduce pain by inhibiting the activity of specific pain receptors.
Pharmacokinetics:
Absorption
aceclofenac is well absorbed after oral administration, with an absolute bioavailability of about 100%. Food does not affect the rate and extent of absorption, and the drug reaches peak plasma concentration within 1-3 hours.
Distribution
aceclofenac is highly protein-bound (more than 99%) to albumin in the plasma. The volume of distribution is relatively small, approximately 25 L, which indicates that the drug does not extensively distribute into the tissues.
Metabolism
aceclofenac undergoes extensive metabolism in the liver, converting it into its primary metabolite, diclofenac, by cytochrome P450 enzymes. Diclofenac is also an active anti-inflammatory drug responsible for much of the clinical effects of aceclofenac. aceclofenac is also metabolized to other inactive metabolites, excreted in the urine.
Elimination and Excretion
aceclofenac and its metabolites are excreted mainly in the urine (70-80%) and, to a lesser extent, in the feces. The elimination half-life of aceclofenac is around 4 hours, and it is mainly eliminated in the form of its metabolites.
Administration:
aceclofenac is usually administered orally in the form of tablets or capsules. The recommended dose of aceclofenac may vary depending on the condition being treated, the severity of the symptoms, and the patient’s age and overall health status. It is essential to follow the dosage instructions the prescribing healthcare provider provides or as directed on the label.
The usual adult dose for aceclofenac is 100 mg to 200 mg per day, taken in divided doses. The maximum recommended daily dose is 200 mg. The drug should be taken with food to reduce the risk of gastrointestinal side effects. The tablets should be swallowed whole with water and not crushed or chewed.
Patient information leaflet
Generic Name: aceclofenac
Why do we use aceclofenac?
aceclofenac is a nonsteroidal anti-inflammatory drug (NSAID) that is used to treat pain and inflammation associated with various conditions such as:
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