Acellular tissue engineered vessel

Action and Spectrum

Actions and Spectrum 

Bioengineered vascular implant shows mechanical and biological functionality. Host endothelial cells migrate to the luminal surface of the vessel forms an endothelial layer.

Drug Interaction

Adverse Reaction

Frequency defined:

>10%

Pyrexia

Vascular graft thrombosis

Pain

1-10%

Anastomotic failure

Anastomotic stenosis

Vascular graft infection

Black Box Warning

Black Box Warning

Mid-graft rupture or failure may cause life-threatening hemorrhage.

Contraindication / Caution

Contraindication:

Patients unable to continue long-term antiplatelet therapy post-injury resolution.

Caution:

Graft rupture

Anastomotic failure

Thrombosis

Pregnancy / Lactation

Pregnancy Warnings:

Pregnancy category: N/A

Lactation: Excretion of the drug into the human breast milk is unknown

Pregnancy categories:

• Category A: Satisfactory and well-controlled studies show no evidence of risk to the fetus in the first trimester or in the later trimester.
• Category B: No evidence of risk to fetus found in animal reproduction studies and there are not enough studies on pregnant women.
• Category C: Adverse effects on the fetus found with evidence in animal reproduction studies and no adequate evidence for an effect in humans, care must be taken for potential risks in pregnant women.
• Category D: There is adequate data available with sufficient evidence of human fetal risk from various platforms, but despite potential risks may be used only in emergency cases for potential benefits.
• Category X: Drugs listed in this category clearly outweigh risks over benefits. These category drugs should be prohibited for pregnant women.
• Category N: There is no data available for the drug under this category.

Pharmacology

Pharmacology:

Not known

Pharmacodynamics:

Not known

Pharmacokinetic:

ADME is not studied yet.

Adminstartion

Administration

It is administered with surgical implantation to replace injured extremity artery.

Patient Information Leaflet

Patient Information Leaflet

Generic Name: acellular tissue engineered vessel

Why do we use acellular tissue engineered vessel?

Acellular tissue engineered vessel is used as a vascular conduit for urgent revascularization in extremity arterial injury when autologous vein is unavailable.