acetyl hexapeptide-8 amide

Action and Spectrum

Actions and spectrum:

Acetyl hexapeptide-8 amide is known to inhibit the SNAP25 component present in the SNARE complex competitively. SNARE complex plays a role in fusion and vesicle docking at the time of release of neurotransmitters into the synapses. Inhibition of SNAP25 alters the release of a neurotransmitter that is calcium-dependent, which is essential for muscle contraction.

Drug Interaction

Adverse Reaction

Frequency not defined

Stinging

Dryness at the site of application

Redness

Black Box Warning

Black Box Warning

No special black box warning is available

Contraindication / Caution

Contraindication/Caution:

Contraindication:

Hypersensitivity

Pregnancy / Lactation

Pregnancy consideration:

Safety and efficacy studies about the use of acetyl hexapeptide-8 amide in pregnancy are not available

Lactation:

Data about the excretion of acetyl hexapeptide-8 amide into human milk is unknown.

Pregnancy category:

• Category A: Studies that were well-controlled and met expectations revealed no risk to the fetus in the first or second trimester.
• Category B: There was a lack of studies on pregnant women and no evidence of risk to the fetus in animal experiments.
• Category C: There was evidence of risk of adverse effects in animal reproduction studies, and there was no adequate evidence in human studies that must take care of potential risks in pregnant women.
• Category D: adequate data with sufficient evidence of human fetal risk from various platforms, but despite the potential risk, and used only in emergency cases for potential benefits.
• Category X: Drugs listed in this category outweigh the risks over benefits. Hence, these categories of drugs need to be avoided by pregnant women.
• Category N: There is no data available for the drug under this category

Pharmacology

Pharmacology:

Acetyl-hexapeptide-8 amide is a humectant and skin conditioning agent. It is a peptide composed of 6 amino acids.

Pharmacodynamics:

Acetyl hexapeptide-8 amide is a peptide fragment of SNAP-25, a substrate of botox (botulinum toxin).

Pharmacokinetics:

Limited data available

Adminstartion

Administration:

Acetyl hexapeptide-8 amide should be applied topically as suggested by the dermatologist.

Patient Information Leaflet

Patient information leaflet

Generic Name: acetyl hexapeptide-8 amide

Why do we use acetyl hexapeptide-8 amide?

Acetyl hexapeptide-8 amide is a peptide used as an anti-wrinkling and skin conditioning agent.