acetyldigitoxin

Action and Spectrum

Action and Spectrum: 

It inhibits the sodium potassium ATPase pump enhances the sodium levels and calcium levels in myocardial cells. 

Drug Interaction

Adverse Reaction

Frequency not defined 

atrial fibrillation 

dizziness 

Nausea and vomiting 

Fatigue 

Loss of appetite 

Headache 

Fatigue 

Diarrhea 

Muscle pain 

Black Box Warning

Black Box Warning: 

There is no black box warning associated with acetyldigitoxin. 

Contraindication / Caution

Contraindication/Caution: 

Contraindication: 

Hypersensitivity reactions 

Tachycardia 

Hypokalemia 

Caution: 

Renal impairment 

Hepatic impairment 

Pregnancy / Lactation

Pregnancy Warnings: 

Pregnancy Category: 

Not Available 

Lactation: 

The excretion of drug in human breast milk is unknown 

Pregnancy Categories: 

Category A: Satisfactory and well-controlled studies show no evidence of risk to the fetus in the 1st trimester or 2nd trimester. 

Category B: No evidence of risk to fetus found in animal reproduction studies and there are not enough studies on pregnant women. 

Category C: Adverse effects on the fetus found with evidence in animal reproduction studies and no adequate evidence for an effect in humans, care must be taken for potential risks in pregnant women. 

Category D: There is adequate data available with sufficient evidence of human fetal risk from various platforms, but despite potential risks may be used only in emergency cases for potential benefits. 

Category X: Drugs listed in this category clearly outweigh risks over benefits. These category drugs should be prohibited for pregnant women. 

Category N: There is no data available for the drug under this category. 

Pharmacology

Pharmacology: 

It is used to treat congestive heart failure and works by inhibiting the sodium potassium ATPase pump enhance the sodium levels and calcium levels in myocardial cells. 

Pharmacodynamics: 

It reduces the activity of  AV nodes capability which helps in transmiting the electrical impulses. 

Pharmacokinetics: 

Absorption 

Bioavailability is 60%-80%. 

Distribution: 

It is widely distributed into the blood stream. 

Metabolism 

It involves in hepatic metabolism. 

Elimination and Excretion: 

Excreted renally 

Adminstartion

Administration: 

It is administered orally in the form of capsules and tablets. 

Patient Information Leaflet

Patient information leaflet 

Generic Name: acetyldigitoxin 

Pronounced: (uh-SEET-il-di-JI-tox-in) 

Why do we use acetyldigitoxin? 

It belongs to the class of cardiac glycoside involves in fast digitalisation to treat congestive heart failure (CHF).