Anthropometric Measurements as Predictors of Low Birth Weight Among Tanzanian Neonates: A Hospital-Based Study
November 7, 2025
Free CME credits
Both our subscription plans include Free CME/CPD AMA PRA Category 1 credits.
Brand Name :
Aramact
Synonyms :
actarit
Class :
DMARD
Brand Name :
Aramact
Synonyms :
actarit
Class :
DMARD
Dosage forms and strengths
Oral tablet
100 mg
In vivo data suggests taking 300 mg orally daily for the 24 weeks therapy period
Not indicated
Dosage forms and strengths
Oral tablet
100 mg
Actions and Spectrum:
Action:
Anti-Inflammatory: actarit exerts its primary action by reducing inflammation in the body. This is achieved by suppressing the synthesis of inflammatory agents like prostaglandins and cytokines, which are pivotal components of the inflammatory reaction.
Immunomodulatory: actarit also has immunomodulatory effects. One potential benefit is its ability to modulate the immune system by inhibiting the excessive activity of immune cells seen in autoimmune conditions, thereby preventing the immune system from targeting healthy tissues.
Spectrum:
Rheumatoid Arthritis: actarit is most prescribed for rheumatoid arthritis, where it helps reduce joint inflammation and slow down the progression of the disease.
Psoriatic Arthritis: actarit may be used in some cases of psoriatic arthritis, an autoimmune condition that affects both the skin (psoriasis) and the joints.
Â
Abdominal pain
Itching
Rash
Cough
Decreased appetite
Mouth sores
Dry mouth
Decrease in blood cell count
Black Box Warning:
None
Contraindication/Caution:
Hypersensitivity: actarit should not be used in individuals who have a known hypersensitivity or allergy to the active ingredient or any other components of the medication.
Gastrointestinal Disorders: actarit may irritate the gastrointestinal tract and lead to gastrointestinal bleeding or ulcers. It should be used cautiously in individuals with a history of gastrointestinal problems.
Pregnancy and Breastfeeding: The safety of actarit during pregnancy and breastfeeding is not well established. It is advisable to utilize this treatment exclusively for pregnant or nursing women when the advantages surpass the potential drawbacks, and while being supervised by a medical practitioner.
Pregnancy warnings:Â Â Â
Pregnancy category: N/A
Lactation:Â Excreted into human milk is unknown
Pregnancy Categories:
Category A:Â Studies that were well-controlled and met expectations revealed no risk to the fetus in either the first or second trimester.
Category B: There were a lack of studies on pregnant women and no evidence of risk to the fetus in animal experiments.
Category C:Â there was evidence of risk of adverse effects in animal reproduction studies, and no adequate evidence in human studies must take care of potential risks in pregnant women.
Category D:Â adequate data with sufficient evidence of human fetal risk from various platforms, but despite the potential risk, and used only in emergency cases for potential benefits.
Category X:Â Drugs listed in this category outweigh the risks over benefits. Hence these categories of drugs need to be avoided by pregnant women.
Category N:Â There is no data available for the drug under this category
Pharmacology:
actarit belongs to a class of drugs known as disease-modifying antirheumatic drugs (DMARDs) and has anti-inflammatory and immunosuppressive properties.
Pharmacodynamics:
Anti-inflammatory Effects: actarit inhibits the production of inflammatory mediators, such as prostaglandins and leukotrienes. It achieves this by suppressing the activity of enzymes like cyclooxygenase (COX) and lipoxygenase (LOX), which are involved in the synthesis of these inflammatory molecules.
Immunosuppression: actarit has immunosuppressive properties, which can help modulate the immune response. It inhibits the proliferation of certain immune cells, particularly T-lymphocytes, and reduces the production of cytokines involved in the inflammatory response.
Pharmacokinetics:
Absorption
actarit is well absorbed after oral administration, leading to peak plasma levels attained within a time of 1-2 hours following administration.
Distribution
It has a relatively small volume of distribution, suggesting limited tissue penetration.
Metabolism
actarit undergoes extensive hepatic metabolism, primarily through the CYP1A2 enzyme, resulting in the formation of various metabolites.
Excretion and Elimination
The metabolites of actarit are excreted primarily in the urine, with a half-life of approximately 2 to 3 hours.
Administration:Â
actarit is typically taken with meals to reduce stomach upset. It’s important to take it exactly as prescribed.
The route of administration is oral.
Patient information leaflet
Generic Name: actarit
Why do we use actarit?
actarit has been used in the management of rheumatoid arthritis, which is an autoimmune disease that causes joint inflammation and can lead to joint damage.
actarit has also been studied for its potential benefits in osteoarthritis, which is a degenerative joint disease. It may help alleviate pain and improve joint function in some cases.
Some research has explored the use of actarit in psoriatic arthritis, an autoimmune condition that affects joints and is often associated with psoriasis. It may help reduce joint inflammation and symptoms.
Both our subscription plans include Free CME/CPD AMA PRA Category 1 credits.
On course completion, you will receive a full-sized presentation quality digital certificate.
A dynamic medical simulation platform designed to train healthcare professionals and students to effectively run code situations through an immersive hands-on experience in a live, interactive 3D environment.
When you have your licenses, certificates and CMEs in one place, it's easier to track your career growth. You can easily share these with hospitals as well, using your medtigo app.
