RyR1 Structural Alterations Explain Statin-Associated Muscle Dysfunction
December 16, 2025
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Brand Name :
N/A
Synonyms :
albifylline
Class :
Xanthine derivative
Brand Name :
N/A
Synonyms :
albifylline
Class :
Xanthine derivative
Dosage forms and strengths
Acute hemorrhagic shock
In vivo data suggests the dose of 25mg/kg IV helps in substantial amelioration in the liver’s microvascular blood flow
Indicated for Acute Hemorrhagic shock
In vivo data suggests the dose of 25mg/kg IV helps in substantial amelioration in the liver's microvascular blood flow
Not indicated
Actions and Spectrum:
Action:
Research indicates that albifylline increases renal clearance of yeast and reduces the level of yeast present in rat kidneys that have been infected with candida albicans. Furthermore, it also possesses antifungal properties, which prevent amphotericin B-induced acute renal failure in rats.
Limited information available
Black Box Warning:
None
Contraindication/Caution:
Contraindications:
Hypersensitivity
Cautions:
Pregnancy warnings:
Pregnancy category: N/A
Lactation: Excreted into human milk is unknown
Pregnancy Categories:
Pharmacology: Albifylline is a cyclic PDE inhibitor.
Pharmacodynamics:
Research has established it effectively flushes out the yeasts from the urinary system as well as slows yeast proliferation in kidneys of experimental rats. Also, albifylline is beneficial in minimizing AFB connected to amphotericin B induced acute renal failure in rats.
Pharmacokinetics:
Limited data available
Administration:
It is administered intravenously.
Patient information leaflet
Generic Name: albifylline
Why do we use albifylline?
The investigation has revealed that albifylline helps improve urine clearance and keeps yeast levels in the rat’s kidneys low if the rats are infected by Candida albicans.
Furthermore, it shows antifungal properties in the experimental candidiasis systemic syndrome and has been suggested to decrease the acute lung injury in the guinea pigs that are septic.
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