alfuzosin/dutasteride

Action and Spectrum

Actions and Spectrum: 

Actions: 

The combination of alfuzosin/dutasteride is used to relieve the symptoms that emerge from BPH, where urinary problems, especially at night, occur.  

Spectrum: 

 The spectrum of the combination of alfuzosin/dutasteride is used in BPH to relieve the symptoms of urination problems and bladder problems. 

Drug Interaction

Adverse Reaction

Frequency defined  

Ejaculation disorder 

Fatigue 

Impotence 

Angioedema 

Swollen lips 

Chest pain 

Erectile dysfunction 

Constipation 

Orthostatic hypertension 

Urticaria 

Dizziness 

Infection 

Stomach pain 

Rash 

Decreased libido 

Sinus inflammation 

Dyspepsia 

Pharyngitis 

Headache 

Decreased semen volume 

Black Box Warning

Black Box Warning: 

Donation of blood is stopped for 6 months while on this combinational drug.  Avoid driving as this combination can cause dizziness and blurring of the vision.

Contraindication / Caution

Contraindication/Caution: 

Contraindications 

• Hypersensitivity 
• Cataract 
• Kidney disease 
• Liver disease 

Cautions 

• Driving 
• Hepatic impairment 
• Renal impairment 
• Pediatrics 
• Pregnancy 
• Lactation 

Pregnancy / Lactation

Pregnancy consideration:  

No data is available regarding the administration of the drug during pregnancy. 

Breastfeeding warnings:  

No data is available regarding the excretion of drug in breast milk. 

Pregnancy category: 

Category A: well-controlled and satisfactory studies show no risk to the fetus in the first or later trimester. 

Category B: there was no evidence of risk to the fetus in animal studies, and there were not enough studies on pregnant women. 

Category C: there was evidence of risk of adverse effects in animal reproduction studies, and no adequate evidence in human studies must take care of potential risks in pregnant women.    

Category D: adequate data with sufficient evidence of human fetal risk from various platforms, but despite the potential risk, and used only in emergency cases for potential benefits.    

Category X: Drugs listed in this category outweigh the risks over benefits. Hence these categories of drugs need to be avoided by pregnant women.    

Category N: No data is available for the drug under this category. 

Pharmacology

Pharmacology: 

A combination of alfuzosin/dutasteride shows the action of alphablocker/5-alpha reductase inhibitor by relaxing both bladder muscles and prostate gland at the exit, allowing free flow of urine, thereby relieving symptoms that emerge from BPH. 

Pharmacodynamics: 

alfuzosin relaxes the prostate gland, and dutasteride reduces inflammation of prostate gland muscles by decreasing the dihydrotestosterone hormone, which relieves symptoms of BPH, reduces the need for prostate surgery, and decreases the risk of urinary retention. 

Pharmacokinetics: 

Absorption 

The bioavailability is 49% for alfuzosin and 60% for dutasteride. 

The time to achieve peak effect is 8 hours for alfuzosin and 2-3 hours for dutasteride. 

Distribution 

Protein-bound is 82-90% for alfuzosin and 96% for dutasteride 300-500 L/kg. 

The volume of distribution is 3.2 L/kg for alfuzosin and 96% for dutasteride. 

Metabolism 

A combination of these drugs is metabolized in the liver. 

Elimination and Excretion 

The half-life is 10 hours for alfuzosin and five weeks for dutasteride. 

Alfuzosin is excreted 69% in feces and 24% in urine, and dutasteride is eliminated as its metabolites in urine and feces. 

Adminstartion

Administration: 

Swallow the tablet with a drink of water, and it can be taken with food or after having it. It should be taken at the same time every day. Keep it out of reach of children and store it In a cool, dry place. Don’t double dose if you skipped it. 

Patient Information Leaflet

Patient information leaflet 

Generic Name: alfuzosin/dutasteride 

Pronounced: al-FYOO-zoh-sin/doo-TAS-tuh-ryd 

Why do we use alfuzosin/dutasteride? 

A combination of alfuzosin/dutasteride shows the action of alphablocker/5-alpha reductase inhibitor by relaxing both bladder muscles and prostate gland at the exit, allowing free flow of urine, thereby relieving symptoms that emerge from BPH.