2025 Guidelines for the Evaluation and Management of Adults With Congenital Heart Disease
December 19, 2025
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Brand Name :
panretin
Synonyms :
Alitretinoin topical
Class :
Anti-neoplastic, retinoid
Brand Name :
panretin
Synonyms :
Alitretinoin topical
Class :
Anti-neoplastic, retinoid
Dosage Forms & Strengths
Gel
0.1%
Apply every 12 hours to lesions initially, then increase to every 6-8 hours based on the patient tolerance
Apply every 12 hours to the cutaneous lesion
Apply every 12 hours to the cutaneous lesion
may enhance the serum concentration of CYP3A4 inhibitors
may increase the photosensitizing effect
may increase the toxic effects
may increase the photosensitising effect
may increase the photosensitizing effect
applying resorcinol with alitretinoin topical on the same area may lead to excessive drying and irritation of the skin
Frequency defined:
>10%
Pruritis
Pain
Rash
Paresthesia
1-10%
Edema
Paresthesia
Exfoliative dermatitis
Skin disorders
Pregnancy consideration: D
Lactation: Excretion of the drug in human breast milk is unknown
Pregnancy category:
Category A: well-controlled and Satisfactory studies show no risk to the fetus in the first or later trimester.
Category B: there was no evidence of risk to the fetus in animal studies, and there were not enough studies on pregnant women.
Category C: there was evidence of risk of adverse effects in animal reproduction studies, and no adequate evidence in human studies must take care of potential risks in pregnant women.
Category D: adequate data available with sufficient evidence of human fetal risk from various platforms, but despite the potential risk, and used only in emergency cases for potential benefits.
Category X: Drugs listed in this category outweigh the risks over benefits. Hence these categories of drugs need to be avoided by pregnant women.
Category N: There is no data available for the drug under this category
Patient information leaflet
Generic Name: alitretinoin topical
Pronounced: a-li-TRET-i-noin topical
Why do we use alitretinoin topical?
It is used to treat skin lesions in patients with Kaposi’s sarcoma (AIDS-related cancer)
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