allantoin/triclosan/vitamin e/zinc oxide

Action and Spectrum

Actions and Spectrum: 

Action: 

allantoin is a natural compound derived from plants like comfrey. It is known for its soothing and moisturizing properties. allantoin helps promote skin healing, reduce irritation, and stimulate healthy tissue growth. It is often used in skincare products to calm and protect the skin. 

triclosan is an antimicrobial and antibacterial agent. It kills/inhibits the growth of bacteria, fungi, and other microorganisms. triclosan has been commonly used in antibacterial soaps and personal care products for its ability to reduce bacterial contamination. 

vitamin E is known for its moisturizing and anti-aging properties. vitamin E can help improve skin texture, reduce inflammation, and support overall skin health. 

zinc oxide is mineral sunscreen ingredient that provides broad-spectrum UV protection. It works by physically blocking and scattering UVA and UVB rays from the sun, preventing sunburn and UV-related skin damage. 

Spectrum:  

allantoin is generally well-tolerated and suitable for various skin types, making it a common ingredient in moisturizers, lotions, and creams. 

triclosan’s spectrum of action primarily targets a wide range of bacteria and some fungi. However, due to concerns about potential environmental and health risks, its use has been restricted or banned in some products in various regions. 

vitamin E is suitable for various skin types and is commonly found in skincare products like moisturizers, serums, and sunscreens.  

zinc oxide is highly effective against a broad range of UVA and UVB wavelengths, making it a versatile ingredient in sunscreens and sunblocks. It is considered a physical or mineral sunscreen agent and is well-tolerated by most skin types, including sensitive skin. 

Drug Interaction

Adverse Reaction

Frequency not defined 

Rash 

Itchy skin 

Allergic skin reactions 

Black Box Warning

Black Box Warning: 

None 

Contraindication / Caution

Contraindication/Caution: 

Contraindication 

Allergies: allantoin is generally considered safe for most people when used topically. However, individuals with known allergies or sensitivities to allantoin or its derivatives should avoid products containing this ingredient. 

Adverse effects: The use of triclosan has raised concerns due to potential adverse effects, and its use in consumer products has been restricted or banned in some regions. 

vitamin E is typically safe for most people when used topically. However, individuals with known allergies to vitamin E or skin conditions such as eczema may be more prone to irritation/allergic reactions from products containing high vitamin E concentrations. 

zinc oxide is considered safe for most people when used in skincare products.  

Some individuals with susceptible skin may experience minor irritation or redness when using products with high concentrations of zinc oxide. 

Caution 

allantoin is generally safe for topical use. However, some individuals with sensitive or allergy-prone skin may experience mild irritation/allergic reactions when using allantoin products. If you notice any adverse reactions, discontinue use and consult a dermatologist. 

triclosan has raised concerns due to potential adverse effects on human health and the environment. While it has been used in antibacterial products, including soaps and toothpaste, it’s essential to consider the following: 

Avoid the prolonged or excessive use of triclosan products, as it may disrupt the natural balance of the skin’s microbiome. 

Due to concerns about antibiotic resistance, some experts recommend avoiding triclosan-containing products altogether. 

Be aware of any regulatory restrictions or bans on triclosan in your region, as it has been limited or prohibited in certain consumer products in some areas. 

vitamin E is generally safe for topical use. However, consider the following cautions: 

Some individuals with highly sensitive or allergy-prone skin may experience irritation/allergic reactions when using products with high vitamin E concentrations. 

If you have a known allergy to vitamin E or its derivatives, avoid products containing this ingredient. 

Be cautious with vitamin E oil or capsules applied directly to the skin, as high concentrations can irritate. 

zinc oxide is considered safe for most people when used in skincare products. However, keep in mind the following cautions: 

Some individuals with susceptible skin may experience minor irritation or redness when using products with high concentrations of zinc oxide. If irritation occurs, discontinue use. 

Pregnancy / Lactation

Pregnancy consideration:  

US FDA pregnancy category: Not assigned. 

Lactation:   

Excreted into human milk: Not known. 

Pregnancy category: 

• Category A: well-controlled and Satisfactory studies show no risk to the fetus in the first or later trimester. 
• <b>Category B: there was no evidence of risk to the fetus in animal studies, and there were not enough studies on pregnant women. 
• Category C: there was evidence of risk of adverse effects in animal reproduction studies, and no adequate evidence in human studies must take care of potential risks in pregnant women.    
• Category D: adequate data with sufficient evidence of human fetal risk from various platforms, but despite the potential risk, and used only in emergency cases for potential benefits.    
• Category X: Drugs listed in this category outweigh the risks over benefits. Hence, these categories of drugs need to be avoided by pregnant women.    
• Category N: There is no data available for the drug under this category. 

Pharmacology

Pharmacology: 

allantoin is a naturally occurring compound used in skincare for its skin-soothing and wound-healing properties, promoting tissue regeneration and reducing irritation. Although limited or banned in some regions, triclosan has been utilized as an antibacterial agent to inhibit microorganism growth in personal care products; it disrupts bacterial cell membranes and metabolic processes.

vitamin E, an antioxidant, is employed in skincare to combat oxidative stress, reduce inflammation, and moisturize the skin by neutralizing free radicals and promoting skin health. zinc oxide a mineral sunscreen ingredient that provides broad-spectrum UV protection by physically blocking and scattering UVA and UVB rays, thus preventing sunburn and UV-induced skin damage while being suitable for sensitive skin due to its minimal skin irritation potential. 

Pharmacodynamics: 

Mechanism of action: allantoin soothes and promotes skin healing by stimulating tissue regeneration and reducing inflammation. triclosan, an antibacterial agent, disrupts bacterial cell membranes and metabolic processes, inhibiting microorganism growth. vitamin E acts as an antioxidant. zinc oxide generally forms a physical barrier on the skin’s surface, providing broad-spectrum UV protection by scattering and blocking UVA and UVB rays, thereby preventing sunburn and UV-induced skin damage. 

Pharmacokinetics: 

Absorption 

allantoin is primarily used topically in skincare products. It is generally well-absorbed when applied to the skin, allowing it to exert its soothing and moisturizing effects locally. 

triclosan can be absorbed through the skin when applied topically in personal care products. It may also be absorbed through the gastrointestinal tract if ingested. 

vitamin E can be absorbed through the gastrointestinal tract when ingested orally. When applied topically, it is absorbed by the skin. 

zinc oxide is not significantly absorbed through intact skin. Instead, it forms a protective barrier on the skin’s surface. 

Distribution 

allantoin is distributed within the skin’s epidermal and dermal layers, where it can promote healing and reduce irritation. 

triclosan, when absorbed, can be distributed throughout the body via the bloodstream. 

Once absorbed, vitamin E is distributed throughout the body via the bloodstream and is transported to various tissues. 

When applied topically in sunscreens, zinc oxide remains on the skin’s surface and does not distribute systemically throughout the body. 

Metabolism 

allantoin is not significantly metabolized in the body. It usually undergoes minimal chemical changes. 

triclosan can undergo hepatic metabolism (metabolism in the liver) to form various metabolites. Some of these metabolites may be conjugated and eliminated in urine or feces. 

vitamin E is metabolized in the liver, transforming into various metabolites. 

zinc oxide does not undergo metabolism in the body, as it remains on the skin’s surface. 

Elimination and Excretion 

Since allantoin is topically applied, it is not excreted from the body through typical metabolic pathways but instead remains on the skin’s surface or is eventually washed off during daily activities. 

triclosan and its metabolites can be excreted through urine and feces. However, it may accumulate in body tissues over time, leading to concerns about potential long-term effects. 

vitamin E and its metabolites are excreted through bile and feces. Some unmetabolized vitamin E may also be excreted through urine. 

zinc oxide is not excreted through typical metabolic pathways since it is not absorbed into the bloodstream. It is usually removed by washing or sweating. 

Adminstartion

Administration: 

allantoin, triclosan, vitamin E, and zinc oxide are used in various skincare and personal care products, and their administration or application methods depend on the specific product and its intended use.  

allantoin is typically found in creams, lotions, ointments, and skin care products designed for topical use.  

You are cleansing your skin gently before applying the product. 

Apply a small amount of the product to your skin’s affected area(s). 

I was massaging it in until it was absorbed. 

I am using it as directed, often once or twice daily. 

triclosan has been used in various products, including antibacterial soaps and toothpaste. However, its use has been restricted or banned in some regions because of concerns about its environmental impact and potential antibiotic resistance.  

Follow the product’s specific instructions for use, including the duration and frequency of application. 

Be mindful of regulatory restrictions in your region and consider using alternative products if triclosan is banned or limited. 

vitamin E is typically found in skincare products like moisturizers, serums, and creams. Here’s how to apply products containing vitamin E: 

Cleanse your face and pat it dry before application. 

Take a small amount of the product and gently massage it into your skin. 

Follow the product’s recommended usage instructions, which may vary depending on the product type and formulation. 

zinc oxide is primarily used in sunscreens and some skincare products. When applying products containing zinc oxide: 

Apply sunscreen with zinc oxide generously and evenly to all exposed skin areas before sun exposure. 

Reapply as directed, especially after swimming, sweating, or towel drying. 

Ensure thorough coverage for adequate sun protection. 

Patient Information Leaflet

Patient information leaflet 

Generic Name: allantoin/triclosan/vitamin e/zinc oxide 

Why do we use allantoin/triclosan/vitamin e/zinc oxide? 

A combination of allantoin, triclosan, vitamin E, and zinc oxide may be found in various skincare and personal care products, each contributing specific benefits. Here are potential uses for such a combination: 

Sunscreen and After-Sun Products: 

zinc oxide provides broad-spectrum UV protection, safeguarding the skin from harmful UVA and UVB rays. 

vitamin E is an antioxidant that reduces UV-induced oxidative stress and supports skin health. 

allantoin helps soothe and moisturize the skin, reducing irritation from sun exposure. 

triclosan, if present, may help inhibit the growth of bacteria on the skin, especially in after-sun products. 

Wound Healing and Scar Management: 

allantoin’s wound-healing properties aid in tissue repair and reduce inflammation. 

When used in wound care, zinc oxide can provide a protective barrier and support the healing process. 

vitamin E may help minimize scar formation and improve skin texture. 

triclosan, if present, can help maintain cleanliness around the wound. 

Diaper Rash Creams: 

zinc oxide is commonly used in the diaper rash creams for its skin-protective properties. 

allantoin soothes and reduces skin irritation, crucial for babies with diaper rash. 

vitamin E contributes to skin health and can help prevent further irritation. 

triclosan, if included, may assist in maintaining hygiene in the diaper area. 

Antibacterial Skin Products: 

triclosan is an antibacterial agent used in hand sanitizers and soap products to reduce bacterial contamination. 

allantoin soothes and moisturizes the skin, preventing dryness from frequent handwashing. 

vitamin E helps maintain skin health by reducing the impact of harsh chemicals and frequent handwashing. 

If used, zinc oxide contributes to skin protection and overall well-being. 

Skin Repair and Nourishment: 

vitamin E and allantoin provide moisture and antioxidant protection to the skin. 

allantoin supports skin healing and reduces irritation. 

zinc oxide may offer additional protection against environmental stressors. 

triclosan, if present, can help maintain skin hygiene. 

Anti-Aging Products: 

vitamin E acts as an antioxidant, reducing the appearance of fine lines and wrinkles. 

allantoin helps improve skin texture and reduce signs of aging. 

zinc oxide protects against UV damage, a critical factor in premature aging. 

triclosan, if included, may assist in maintaining cleanliness and preventing bacterial contamination.