allogeneic processed thymus tissue

Action and Spectrum

Actions and Spectrum: 

allogeneic processed thymus tissue is a medical product used for the treatment of certain conditions related to the immune system. It contains thymic tissue from a donor, which has been processed and purified to remove immune cells that could cause rejection. 

The spectrum of actions of allogeneic processed thymus tissue is related to its ability to reconstitute the immune system by providing functional thymic tissue. The thymus is a gland located in the chest that is responsible for the development and maturation of T-cells, which are important cells of the immune system that help to fight off infections and cancer. 

Drug Interaction

Adverse Reaction

Frequency Defined  

>10%  

Hypomagnesemia (16%)  

Cytokine release syndrome (18%)  

Rash (15%)  

Thrombocytopenia (12%)  

Hypertension (19%)  

Renal impairment/failure (12%)  

1-10%  

Respiratory distress (8%)  

Neutropenia (9%)  

Graft versus host disease (GVHD) (10%)

Black Box Warning

Contraindication / Caution

Contraindication/Caution: 

Contraindications: 

• Hypersensitivity or allergic reactions to any of the components of the product 
• Active infections or other serious medical conditions that could be worsened by the use of allogeneic processed thymus tissue 
• Immunosuppression due to medication or medical conditions such as HIV/AIDS, which could increase the risk of infection or other adverse effects. 

Caution should be taken when using allogeneic processed thymus tissue in patients who: 

• Have a history of allergies or hypersensitivity reactions 
• Have an underlying medical condition that could increase the risk of infection, such as diabetes or chronic liver or kidney disease 
• Are pregnant or breastfeeding, as there is limited data on the safety of the product in these populations. 

Pregnancy / Lactation

Pregnancy warnings:     

Pregnancy category: N/A 

Lactation: Excreted into human milk is unknown 

Pregnancy Categories:         

Category A: Studies that were well-controlled and met expectations revealed no risk to the fetus in either the first or second trimester. 

Category B: There were lack of studies on pregnant women and no evidence of risk to the foetus in animal experiments.   

Category C: there was evidence of risk of adverse effects in animal reproduction studies, and no adequate evidence in human studies must take care of potential risks in pregnant women.    

Category D: adequate data available with sufficient evidence of human fetal risk from various platforms, but despite the potential risk, and used only in emergency cases for potential benefits.   

Category X: Drugs listed in this category outweigh the risks over benefits. Hence these categories of drugs need to be avoided by pregnant women.    

Category N: There is no data available for the drug under this category

Pharmacology

Pharmacology:  

Allogeneic processed thymus tissue is a medication used in the treatment of primary immunodeficiency disorders. The pharmacology of this medication involves its ability to provide immune support by introducing healthy thymus tissue into the patient’s body.  

Pharmacodynamics: 

The pharmacodynamics of allogeneic processed thymus tissue involve several mechanisms. Thymus tissue contains specialized cells called T-cells that play a critical role in the immune system. Allogeneic processed thymus tissue contains viable T-cells and other cells that help to stimulate the immune system, which can help to fight infections and other diseases.  

Pharmacokinetics: 

Absorption  

allogeneic processed thymus tissue can be administered via various routes, such as intravenous, intramuscular, or subcutaneous injection. The absorption of the tissue depends on the route of administration.  

Distribution  

The processed thymus tissue is distributed throughout the body via the bloodstream. It may accumulate in organs such as the thymus gland, spleen, and lymph nodes, where it can stimulate immune cells.  

Metabolism  

allogeneic processed thymus tissue is composed of proteins and peptides, which can be broken down and metabolized by the body’s enzymes. The rate and extent of metabolism may vary depending on the individual’s immune system and other factors.  

Elimination and Excretion  

The excretion of allogeneic processed thymus tissue depends on the route of administration and the metabolic rate.

Adminstartion

Administration:  

allogeneic processed thymus tissue is a medication used in the treatment of primary immunodeficiency disorders. The administration of allogeneic processed thymus tissue should always be under the guidance of a healthcare professional, as they will determine the appropriate dosage and frequency of administration based on your individual medical condition and other factors. 

Patient Information Leaflet

Patient information leaflet 

Generic Name: allogeneic processed thymus tissue 

Why do we use allogeneic processed thymus tissue? 

allogeneic processed thymus tissue is used in the treatment of primary immunodeficiency disorders (PIDs). PIDs are a group of inherited disorders that affect the immune system, making individuals more susceptible to infections, autoimmune diseases, and cancer.