alpha-galactosidase

Action and Spectrum

Actions and Spectrum 

alpha-galactosidase catalyzes the hydrolysis of alpha-galactosides by breaking the glycosidic bond between the alpha-galactose and other sugar molecules in the substrate. This enzymatic action results in the conversion of alpha-galactosides into simpler sugars like galactose and glucose. 

Drug Interaction

Adverse Reaction

Frequency not defined  

Allergic reactions  

Black Box Warning

Black Box Warning 

None 

Contraindication / Caution

Contraindication/Caution: 

Contraindication: 

• Individuals with known allergies to alpha-galactosidase or any of the ingredients in the supplement should avoid its use. 

Caution: 

• Individuals with pre-existing digestive disorders or conditions such as irritable bowel syndrome (IBS) should take caution.  
• Individuals with certain medical conditions should exercise caution. 

Pregnancy / Lactation

Pregnancy consideration: 

Pregnancy category: N/A 

Lactation: Excretion into human milk is unknown  

Pregnancy Categories:         

Category A: well-controlled and Satisfactory studies show no risk to the fetus in the first or later trimester. 

<b>Category B: there was no evidence of risk to the fetus in animal studies, and there were not enough studies on pregnant women.  

Category C: there was evidence of risk of adverse effects in animal reproduction studies, and no adequate evidence in human studies must take care of potential risks in pregnant women. 

Category D: adequate data with sufficient evidence of human fetal risk from various platforms, but despite the potential risk, and used only in emergency cases for potential benefits. 

Category X: Drugs listed in this category outweigh the risks over benefits. Hence these categories of drugs need to be avoided by pregnant women. 

Category N: There is no data available for the drug under this category. 

Pharmacology

Pharmacology  

alpha-galactosidase works by catalyzing the hydrolysis of alpha-galactoside bonds in complex carbohydrates. These bonds are found in substances like raffinose and stachyose, which are present in certain plant-based foods. The enzyme breaks these bonds, converting alpha-galactosides into simpler sugars, primarily galactose and glucose. 

Pharmacodynamics 

alpha-galactosidase is highly specific for its substrates, which are complex carbohydrates containing alpha-galactoside bonds.  

These substrates include raffinose and stachyose, which are found in various plant-based foods. 

Pharmacokinetics 

Limited information not available

Adminstartion

Administration 

alpha-galactosidase is taken orally in the form of tablets and capsules as dietary supplement.

Patient Information Leaflet

Patient information leaflet 

Generic Name: alpha-galactosidase 

Why do we use alpha-galactosidase? 

alpha-galactosidase is commonly used as a dietary supplement to improve digestive health.   

alpha-galactosidase supplements are used in flatulence to reduce the symptoms of excessive gas and bloating.