- March 15, 2022
- Newsletter
- 617-430-5616
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Brand Name :
Xanax, Xanax XR, Niravam
Synonyms :
alprazolam
Class :
Antianxiety agents, Benzodiazepines, Antiemetics
Brand Name :
Xanax, Xanax XR, Niravam
Synonyms :
alprazolam
Class :
Antianxiety agents, Benzodiazepines, Antiemetics
Dosage forms & Strengths:
Tablet
0.25mg
0.5mg
1mg
2mg
Extended-release tablet
0.5mg
1mg
2mg
3mg
Orally disintegrating tablet
0.25mg
0.5mg
1mg
2mg
Oral solution
1mg/ml
Infusion solution
200mg/100 ml
200mg/20 ml
400mg/40 ml
400mg/200 ml
A dose of 0.25-0.5 mg orally every 6 to 8 hours is indicated for 3 to 4 days
Do not outreach the drug dose to more than 4 mg/day
An immediate-release tablet of 0.5 mg is recommended orally every 8 hours for 4 days
An extended-release tablet of 0.5-1 mg orally each day. May increase the dose by 1 mg/day every 3-4 days
Average dose is 3-6 mg orally each day
An immediate-release tablet of 0.5 mg is recommended orally every 8 hours for 4 days
An extended-release tablet of 0.5-1 mg orally each day. May increase the dose by 1 mg/day every 3-4 days
Average dose is 3-6 mg orally each day
1-4 mg of alprazolam orally every 8 hours a day
alprazolam is not recommended for children below 18 years
Refer to adult dosing for panic disorder and anxiety-related depression
Use a potent dose to prevent oversedation or ataxia
Older people sensitive to benzodiazepines should be given a reduced dose
may enhance the CNS depressant effect
may enhance the serum concentration
may enhance the serum concentration of CYP3A4 inhibitors
may enhance the serum concentration of CYP3A4 inhibitors
may decrease the metabolism when combined
may enhance the serum concentration of CYP3A4 Inhibitors
They increase the concentration of alprazolam in serum
It increases the concentration of alprazolam in serum
it increases the concentration of CYP3A4 substrates in serum
CNS depressants increase the effect of flunarizine
it increases the CNS depressing effect of other CNS depressants
it increases the CNS depressing effect of other CNS depressants
it increases the CNS depressing effect of other CNS depressants
it increases the concentration of CYP3A4 in serum
CNS depressants increase the effect of thalidomide
when both drugs are combined, there may be a decreased effect of alprazolam by affecting hepatic or intestinal enzyme cyp3a4 metabolism
CYP3A strong enhancers of the small intestine may reduce the the bioavailability of alprazolam
it increases the effect of CNS depressants
CNS depressants increase the effect of orphenadrine
it increases the effect of CNS depressants
it increases the effect of CNS depressants
it increases the effect of CNS depressants
CNS depressants increase the effect of brexanolone
CYP3A4 inhibitors increase the concentration of carbamazepine in serum
it increases the effect of CNS depressants
it decreases the concentration of CYP3A4 substrates in serum
CYP3A4 inhibitors increase the concentration of flibanserin in serum
it increases the effect of CNS depressants
CYP3A4 inhibitors increase the concentration of midazolam in serum
CYP3A4 inhibitors increase the concentration of nimodipine in serum
it increases the effect of CNS depressants
CNS depressants increase the effect of rotigotine
CYP3A4 inhibitors increase the concentration of sirolimus in serum
CYP3A4 inhibitors increase the concentration of tacrolimus in serum alpra
it decreases the efficacy of antianxiety agents
CNS depressants may enhance the CNS depressant effect of cannabinoid-Containing products
CNS depressants may enhance the CNS depressant effect of cannabinoid-Containing products
CNS Depressants may enhance the CNS depressant effect of Opioid agonists
CNS Depressants may enhance the CNS depressant effect of Opioid agonists
CNS Depressants may enhance the CNS depressant effect of Opioid agonists
may enhance the serum concentration
may enhance the serum concentration
may enhance the serum concentration
may enhance the serum concentration
may enhance the serum concentration
It may enhance sedation when combined with tramadol
It may enhance sedation when combined with a shepherd's purse
Strong CYP3A4 inducers may lower the serum concentration of alprazolam
Strong CYP3A4 inducers may lower the serum concentration of alprazolam
Strong CYP3A4 inducers may lower the serum concentration of alprazolam
Strong CYP3A4 inducers may lower the serum concentration of alprazolam
Strong CYP3A4 inducers may lower the serum concentration of alprazolam
may enhance the concentration of serum when combined with alprazolam
may enhance the concentration of serum when combined with alprazolam
may enhance the concentration of serum when combined with alprazolam
may enhance the concentration of serum when combined with alprazolam
may enhance the concentration of serum when combined with alprazolam
when both drugs are combined, there may be an increased effect of alprazolam by affecting hepatic or intestinal enzyme cyp3a4 metabolism
the effect of alprazolam is decreased by lorlatinib, by altering intestinal or hepatic CYP3A4 enzyme metabolism
CYP3A4 inhibitors increase the concentration of alprazolam in serum
diphenoxylate, when used with alprazolam, increases sedation
nabilone and alprazolam, when used simultaneously, both increase the sedation
The interaction may enhance the drug serum levels of benzodiazepine agonist hypnotics
The interaction may enhance the drug serum levels of benzodiazepine agonist hypnotics
The interaction may enhance the drug serum levels of benzodiazepine agonist hypnotics
it increases the effect of CNS depressants
may increase the sedative effect
may enhance the serum concentration of CYP3A4 inhibitors
may have an increased adverse effect when combined with olanzapine.
may enhance the serum concentration of CYP3A4 inhibitors
may enhance the serum concentration of CYP3A4 inhibitors
it enhances the effect of alprazolam by diminishing the metabolism
it enhances the effect of alprazolam by diminishing the metabolism
it enhances the effect of alprazolam by diminishing the metabolism
it enhances the effect of alprazolam by diminishing the metabolism
alprazolam enhances the level of lithium by reducing renal clearance
it enhances the effect of alprazolam by diminishing the metabolism
it enhances the effect of alprazolam by diminishing the metabolism
it enhances the effect of alprazolam by diminishing the metabolism
it decreases the effect of alprazolam by diminishing the metabolism
zolpidem and alprazolam increase the effect of each other by pharmacodynamic antagonism
CNS depressants increase the effect of zolpidem
Actions and Spectrum:
alprazolam has a broad spectrum of activity and is effective in treating a variety of conditions, including:
The onset of action for alprazolam is rapid, with effects typically felt within 15-30 minutes of administration. The duration of action is relatively short, typically lasting 4-6 hours.
1-10%
Drowsiness
Depression
Headache
Constipation
Diarrhea
Dry mouth
Increased salivation
Talkativeness
Incontinence
Black Box Warning
The black box warning for alprazolam states that:
Contraindication/Caution:
Pregnancy consideration:
Benzodiazepines cross the placenta during gestation and may cause respiratory distress or sedation to the fetus.
Consult the physician before taking the medication
Breastfeeding warnings: lactating females should not breastfeed during the treatment.
Continue breastfeeding after the two half-lives of the last dose.
Pregnancy category:
Pharmacology:
Administration:
alprazolam is usually administered orally, in tablet form, with or without food. The dosage and duration of treatment depend on the patient’s medical condition, age, and response to treatment. The usual starting dose for anxiety disorders is 0.25-0.5 mg administered orally 3 times a day, with gradual dose increases as needed and tolerated up to a maximum daily dose of 4 mg.
The usual starting dose for panic disorder is 0.5 mg administered orally 3 times a day, with gradual dose increases as needed and tolerated up to a maximum daily dose of 10 mg. Elderly patients, patients with hepatic or renal impairment, and patients with other medical conditions may require lower doses of alprazolam. alprazolam should only be used for the shortest duration possible and at the lowest effective dose.
Abrupt discontinuation of the medication can lead to withdrawal symptoms, and the dose should be gradually tapered off under the guidance of a healthcare provider. alprazolam has a potential for abuse and dependence, and its use should be carefully monitored. Patients should not take more than the prescribed dose and should not share their medication with others.
Patient information leaflet
Generic Name: alprazolam
Pronounced: al-prah-zoh-laam
Why do we use alprazolam?
alprazolam is primarily used to treat anxiety disorders, including generalized anxiety disorder (GAD) and panic disorder. It is also sometimes used to treat other conditions, such as insomnia and depression.
Anxiety disorders are characterized by excessive and persistent feelings of fear, worry, and tension that interfere with daily activities. alprazolam can help to reduce these symptoms by enhancing the activity of the neurotransmitter GABA in the brain, leading to a calming effect and a reduction in anxiety.
Panic disorder is a type of anxiety disorder characterized by recurrent and unexpected panic attacks. alprazolam can help to reduce the frequency and severity of panic attacks, as well as the associated symptoms such as palpitations, sweating, and trembling.