Alcohol Consumption Emerges as a Key Risk Factor for Buccal Cancer in India
December 24, 2025
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Brand Name :
Simalvia, Meteospasmyl
Synonyms :
alverine citrate/simeticone
Class :
Antispasodic, Smooth uscle relaxant/Antiflatulent
Brand Name :
Simalvia, Meteospasmyl
Synonyms :
alverine citrate/simeticone
Class :
Antispasodic, Smooth uscle relaxant/Antiflatulent
Dosage Forms & Strengths
Capsule
60 mg/300 mg
Irritable Bowel Syndrome (IBS)
Take one soft capsule 2 to 3 times daily, preferably at the start of meals or when experiencing discomfort
Safety and efficacy are not seen in pediatrics
Refer to the adult dosing
Actions and Spectrum:
Actions:
Alverine Citrate works on muscle spasms in the gut. Simethicone stops gas from forming bubbles. Together they help with belly problems like cramps and bloating.
Spectrum:
Alverine citrate works as a muscle-relaxing medicine. It stops muscle cramps in the stomach and intestines. Simeticone doesn’t have any medicine effects. Instead, it makes gas bubbles stick together. This helps you pass gas easily.
Frequency not defined
Serum bilirubin increased
Pruritus
Anaphylactic shock
Vertigo
Nausea
Increase of liver transaminases
Rash
Headache
Cytolytic hepatitis
Urticaria
Angioedema
Increase in alkaline phosphatase
Black Box Warning:
Speak with your doctor if you experience any new symptoms, if your existing symptoms get worse, or if your symptoms don’t get better after two weeks of treatment. This medication should not be allowed to freeze in its liquid form.
Never operate a machine or drive a vehicle.
Contraindication/Caution:
Contraindications
Cautions
Pregnancy consideration:
Pregnancy category: D
Breastfeeding warnings:
Contraindicated
Pregnancy category: D
Category A: well-controlled and satisfactory studies show no risk to the fetus in the first or later trimester.
<b>Category B: there was no evidence of risk to the fetus in animal studies, and there were not enough studies on pregnant women.
Category C: there was evidence of risk of adverse effects in animal reproduction studies, and no adequate evidence in human studies must take care of potential risks in pregnant women.
Category D: adequate data with sufficient evidence of human fetal risk from various platforms, but despite the potential risk, and used only in emergency cases for potential benefits.
Category X: Drugs listed in this category outweigh the risks over benefits. Hence these categories of drugs need to be avoided by pregnant women.
Category N: No data is available for the drug under this category.
Pharmacology:
Alverine citrate works as a muscle-relaxing medicine. It stops muscle cramps in the stomach and intestines. Simeticone doesn’t have any medicine effects. Instead, it makes gas bubbles stick together. This helps you pass gas easily.
Pharmacodynamics:
Alverine citrate works in two ways. First, it blocks nerve cells from being too active. This stops muscles in the gut from contracting too much. Then, it also blocks pain receptors from working right. This means the gut doesn’t hurt as much. Simethicone acts differently. It is a chemical that stops gas bubbles from forming. By breaking up bubbles, it lets gas leave the body more easily. Alverine blocks muscle cramps and pain. Simethicone gets rid of gas bubbles. Together, they stop belly pain and bloating.
Pharmacokinetics:
Absorption
Absorption of alverine citrate happens fast – peak effect comes in 1.0-1.5 hours.
Elimination and Excretion
Its metabolites leave the body mainly through urine. This medication gets absorbed quickly into the bloodstream, but its breakdown products exit primarily via the kidneys.
Administration:
Alverine citrate is an antispasmodic. Simeticone is an anti-foaming agent. Together, they help manage gut symptoms. Take one soft capsule 2 to 3 times daily, ideally when eating or feeling discomfort. This combo tackles muscle spasms and excess gas. It soothes conditions like IBS where both these issues cause problems.
Patient information leaflet
Generic Name: alverine citrate and simeticone
Pronounced: Al-ver-een sye-trate/Si-met-i-kone
Why do we use alverine citrate and simeticone?
Alverine citrate and simeticone are often given together. They help with stomach issues. Alverine citrate is an antispasmodic drug. It relaxes muscle spasms in the gut. This is good for conditions like irritable bowel syndrome (IBS). Simeticone is an anti-foaming agent. It cuts down gas in the digestive system. Bloating can be eased with this drug. Using both medicines aims to ease varied symptoms. Muscle cramps and gas troubles are handled. This combo approach may work better. Treatment can be easier to stick with.
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