amcinonide

Action and Spectrum

Actions and Spectrum: 

amcinonide is a corticosteroid medication used to treat various skin conditions such as eczema, dermatitis, and allergic reactions. It works by reducing inflammation and suppressing the immune system. 

Drug Interaction

Adverse Reaction

Frequency undefined: 

Striae 

Skin atrophy 

Dryness 

Burning 

Itching 

Irritation 

Acneform lesions 

Hypertrichosis 

Pigmentation changes 

Secondary infection 

HPA suppression 

Black Box Warning

Contraindication / Caution

Contraindication/Caution: 

amcinonide should not be used in people hypersensitive to the drug itself. 

Pregnancy / Lactation

Pregnancy consideration:  

Category C 

Breastfeeding warnings:  

Use the drug with caution during breastfeeding. 

Pregnancy category: 

• Category A: well-controlled and Satisfactory studies do not show risk to the fetus in the first/later trimester.        
• Category B: there was no evidence of risk to the fetus in animal studies, and there were not enough studies on pregnant women.        
• Category C: there was evidence of risk of adverse effects in animal reproduction studies, and no adequate evidence in human studies must take care of potential risks in pregnant women.       
• Category D: adequate data available with sufficient evidence of human fetal risk from various platforms, but despite the potential risk, and used only in emergency cases for potential benefits.        
• Category X: Drugs listed in this category outweigh the risks over benefits. Hence these categories of drugs need to be avoided by pregnant women.        
• Category N: No data is available for the drug under this category. 

Pharmacology

Pharmacology: 

amcinonide is a potent corticosteroid used to reduce inflammation and itching in the skin. It is most often used topically, although it can also be used as an inhaled nasal spray or an intravenous injection. 

Pharmacokinetics: 

It works by reducing inflammation and suppressing the immune system. amcinonide is generally well tolerated when applied topically, with the most common side effects being skin irritation and dryness. 

Pharmacodynamics: 

amcinonide helps in maintaining the moisture in the skin. It acts as an anti-inflammatory agent.  

Absorption 

After it is absorbed into the bloodstream, amcinonide is distributed throughout the body. However, the extent of distribution depends on the formulation of the medication and the specific condition being treated. 

In general, amcinonide has a low affinity for corticosteroid receptors, making it less likely to bind to these receptors and influence the body’s tissues. It helps to minimize the risk of side effects. 

Distribution 

The volume of distribution of amcinonide is unavailable. 

Metabolism 

amcinonide is metabolized in the liver. It is then eliminated from the body through the kidneys. The half-life of amcinonide is relatively short, which means that it is eliminated from the body relatively quickly. 

Elimination and excretion 

The drug is excreted in urine and feces. 

Adminstartion

Administration 

The amcinonide is administered topically through the skin. 

Patient Information Leaflet

Patient information leaflet 

Generic Name: amcinonide 

Pronounced: am-SIN-oh-nide 

Why do we use amcinonide? 

amcinonide helps treat Corticosteroid-Responsive Dermatoses.