aminobenzoate potassium

Action and Spectrum

Actions and Spectrum: 

Action: 

Antifibrotic: Drug has been shown to have antifibrotic properties. It can help reduce excessive scar tissue formation, particularly in conditions such as Peyronie’s disease, where fibrosis affects the penis. 

Antioxidant: It acts as an antioxidant by neutralizing harmful free radicals in the body. This property can help protect cells and tissues from oxidative damage caused by reactive oxygen species. 

Collagen-Stabilizing: Drug helps stabilize collagen, a protein that provides structural support to various tissues in the body. By promoting collagen stability, it may have positive effects on connective tissues, including tendons and ligaments. 

Spectrum: 

Dermatological Conditions: Drug has been used in the treatment of dermatological conditions such as scleroderma and morphea, which involve excessive fibrosis and skin thickening. 

Peyronie’s Disease: It is used in the management of Peyronie’s disease, a condition characterized by the formation of fibrous plaques in the penis, leading to curvature and erectile dysfunction. 

Drug Interaction

Adverse Reaction

Frequency not defined  

Rash 

Hepatotoxicity 

Fever 

Nausea 

Anorexia 

Black Box Warning

Black Box Warning:  

None

Contraindication / Caution

Contraindication/Caution:  

Hypersensitivity: Individuals with a known hypersensitivity or allergic reaction to aminobenzoate potassium or its components should avoid using the medication. 

Renal Impairment: aminobenzoate potassium is primarily excreted through the kidneys. Therefore, individuals with severe renal impairment or kidney disease may require dosage adjustment or should avoid using this medication altogether. 

Gastrointestinal Disorders: Drug may cause gastrointestinal side effects such as nausea, vomiting, or diarrhea. Individuals with severe gastrointestinal disorders should exercise caution when using this medication. 

Blood Disorders: Drug may influence blood clotting. Therefore, individuals with bleeding disorders or taking medications that affect blood clotting should use aminobenzoate potassium cautiously. 

Pre-existing Medical Conditions: It is essential to consider a person’s overall health status and any pre-existing medical conditions before using aminobenzoate potassium. It is essential to consider a person’s overall health status and any pre-existing medical conditions before using aminobenzoate potassium. It may interact with other medications or exacerbate certain conditions, so consulting with a healthcare professional is essential. 

Pregnancy / Lactation

Pregnancy warnings:     

Pregnancy category: N/A 

Lactation: Excreted into human milk is unknown 

Pregnancy Categories:         

Category A: Studies that were well-controlled and met expectations revealed no risk to the fetus in either the first or second trimester. 

Category B: There were a lack of studies on pregnant women and no evidence of risk to the fetus in animal experiments.   

Category C: there was evidence of risk of adverse effects in animal reproduction studies, and no adequate evidence in human studies must take care of potential risks in pregnant women.    

Category D: adequate data with sufficient evidence of human fetal risk from various platforms, but despite the potential risk, and used only in emergency cases for potential benefits.   

Category X: Drugs listed in this category outweigh the risks over benefits. Hence these categories of drugs need to be avoided by pregnant women.    

Category N: There is no data available for the drug under this category

Pharmacology

Pharmacology: potassium aminobenzoate, also known as potassium para-aminobenzoate or PABA (para-aminobenzoic acid) potassium, is a salt of para-aminobenzoic acid. 

Pharmacodynamics:  

Antifibrotic Effects: aminobenzoate potassium has been studied for its antifibrotic properties. Fibrosis is the formation of excessive scar tissue in organs or tissues, often resulting from chronic inflammation or injury. aminobenzoate potassium is believed to inhibit the excessive production of collagen, a major component of scar tissue, thereby preventing or reducing fibrosis. 

Antioxidant Activity: aminobenzoate potassium has been shown to possess antioxidant properties. aminobenzoate potassium may aid in the reduction of inflammation and safeguarding cells against damage by combating oxidative stress and scavenging free radicals. These actions are crucial as free radicals can cause cellular harm, and antioxidants play a significant role in shielding cells from such oxidative stress. 

Pharmacokinetics: 

Absorption 

Drug can be administered orally or topically. When taken orally, it is typically absorbed in the gastrointestinal tract. The absorption rate and extent may depend on various factors, such as the formulation, dosage, and individual patient factors. 

Distribution 

Once absorbed, aminobenzoate potassium can distribute throughout the body via the bloodstream. The exact distribution pattern and extent may depend on protein binding, tissue permeability, and the drug’s physicochemical properties. 

Metabolism 

Drug is metabolized in the body. However, specific details about its metabolism are limited. It is likely that PABA, the parent compound, undergoes various enzymatic reactions in the body, leading to the formation of metabolites.  

Excretion and Elimination 

aminobenzoate potassium and its metabolites are excreted from the body, primarily through the kidneys via urine. The elimination half-life of aminobenzoate potassium and its metabolites can vary and may be influenced by individual factors and the dosage form used. 

Adminstartion

Administration:  

The administration of aminobenzoate potassium should always be done under the supervision and guidance of a healthcare professional. The prescribing doctor will determine the dosage and duration of treatment based on the individual’s specific condition and needs. 

aminobenzoate potassium is available in tablet form and is typically taken orally. The tablets should be swallowed whole with a glass of water, and it is generally recommended to take them with meals to minimize potential gastrointestinal side effects. 

Patient Information Leaflet

Patient information leaflet 

Generic Name: aminobenzoate potassium 

Why do we use aminobenzoate potassium?  

Peyronie’s disease: The Drug is commonly used in treating Peyronie’s disease, a condition characterized by forming fibrous scar tissue within the penis, resulting in penile curvature and sometimes pain during erection. drug has been shown to help reduce fibrosis progression and improve symptoms in some individuals with Peyronie’s disease. 

Dermatology: The Drug has been used topically in treating certain skin conditions, such as morphea and localized scleroderma. These conditions involve the abnormal hardening and thickening of the skin, and drug mechanism of action is thought to involve inhibiting the formation of excessive collagen, thereby reducing skin fibrosis. 

Fibrotic disorders: The Drug has been investigated as a potential treatment for various fibrotic disorders, including systemic sclerosis (also known as scleroderma) and keloids. Fibrotic disorders involve the excessive accumulation of scar tissue or fibrous connective tissue in different organs or tissues of the body. 

Vitiligo: The drug has been used as an adjuvant therapy for vitiligo, characterized by depigmented skin patches. Although the exact mechanism of action is unclear, the drug is thought to help repigment the affected areas and improve the appearance of the skin in some individuals.