aminohippuric acid

Action and Spectrum

Actions and spectrum: 

Actions: 

The renal glomeruli filter aminohippurate which is then secreted into the urine by the proximal tubules. It is possible to determine the effective renal plasma flow and to measure the amount of the drug in the urine by which it can be known to estimate the functional capacity of kidney. 

Drug Interaction

Adverse Reaction

Adverse reactions 

Anaphylaxis 

Tingling 

Angioedema 

vasomotor disturbances 

flushing 

Urticaria 

Cramps 

Nausea 

Vomiting 

Black Box Warning

Black box warning 

During administration of aminohippuric acid, level of electrolytes must be monitored thoroughly 

Contraindication / Caution

Contraindications/Caution 

Contraindications 

Hypersensitivity 

Caution 

Renal impairment 

Hepatic impairment 

Pregnancy 

Lactation 

Low cardiac reserve patients 

Allergy to latex 

Pregnancy / Lactation

Pregnancy & breastfeeding: 

Pregnancy consideration: 

Safety and efficacy data about the use of aminohippuric acid in pregnancy is not established 

Breastfeeding warnings: 

Data about the excretion of the drug into human milk is not known  

Pregnancy category: 

• Category A: well-controlled and satisfactory studies show no risk to the fetus in the first or later trimester. 
• Category B: There was no evidence of risk to the fetus in animal studies, and there were not enough studies on pregnant women. 
• Category C: There was evidence of risk of adverse effects in animal reproduction studies, and no adequate evidence in human studies must take care of potential risks in pregnant women. 
• Category D: Adequate data with sufficient evidence of human fetal risk from various platforms, but despite the potential risk, and used only in emergency cases for potential benefits. 
• Category X: Drugs listed in this category outweigh the risks over benefits. Hence, these categories of drugs need to be avoided by pregnant women. 
• Category N: No data for the drug under this category is available. 

Pharmacology

Pharmacology: 

Aminohippurate is a glycine amide of p-aminobenzoic acid. It is a derivative injection of hippuric acid used to measure renal functioning. 

Pharmacodynamics: 

P-Aminohippuric acid (PAH, PAHA) is the glycine amide of p-aminobenzoic acid. By the glomeruli, it is filtered and secreted actively by the proximal tubules. At lower plasma concentrations (1.0 to 2.0 mg/100 mL), ninety percent of aminohippurate on an average is cleared from the renal blood stream of the kidneys in one circulation. It is very well-suited to the estimation of ERPF due to its high clearance, a relatively nontoxic state achieved only at the over-recommended dose and the analytic determination is precise and simple. This drug is also used for the purpose of secretion ability measurement of the renal tubular cells (transport maximum maximum, TmPAH) as well. This is done through the build-up of the plasma concentration to the levels (40 to 60 mg/100 mL) necessary to overload the tubular cells with aminohippurate. Inulin clearance is typically performed during TmPAH assessments since the knowledge of the glomerular filtration rate (GFR) must be a prerequisite for secretory Tm calculations. 

Pharmacokinetics: 

Elimination and excretion: 

The drug is likely to be excreted via urine. Renal clearance at low concentrations of plasma in a single circulation is observed to be 90%. 

Half-life:

24 minutes 

Adminstartion

Administration: 

The drug should be administered as an intravenous injection directly into the blood stream. 

It should be given by the specialist and carried out under the guidance of licensed medical practitioners. 

Patient Information Leaflet

Patient information leaflet 

Generic Name: aminohippuric acid 

Pronounced: uh-MEE-noh-HIP-yur-ik AS-id 

Why do we use aminohippuric acid? 

It is the most acceptable procedure to control the blood flow in the kidney. This drug assists in calculating ERPF, the plasma flow in the kidney glomeruli that removes the wastes from the blood stream by filtration so that the functional capability of kidneys can be evaluated.