Bronchodilation: aminophylline relaxes the smooth muscles of the bronchial tubes, helping to open up the airways. It is commonly used in the management of asthma, chronic obstructive pulmonary disease, and respiratory conditions to relieve bronchospasm and improve breathing.
Smooth muscle relaxation: aminophylline has a relaxing effect on smooth muscles throughout the body, including those in the bronchial tubes, blood vessels, and gastrointestinal tract. This can help alleviate symptoms related to smooth muscle spasms or constriction.
Increased respiratory drive: aminophylline can stimulate the respiratory centers in the brain, leading to an increased respiratory drive and improved breathing.
Anti-inflammatory effects: aminophylline has been reported to possess anti-inflammatory properties, although its exact mechanisms are not fully understood. This may contribute to its beneficial effects in respiratory conditions associated with inflammation.
Cardiac stimulation: aminophylline can have a mild positive inotropic and chronotropic effect on the heart, meaning it can increase cardiac contractility and heart rate. This effect is more pronounced at higher doses.
Diuresis: aminophylline can stimulate diuresis (increased urine production) by enhancing renal blood flow and promoting sodium and water excretion. This diuretic effect is often used in the management of certain conditions, such as congestive heart failure.