amylmetacresol

Action and Spectrum

Actions and Spectrum  

Actions: 

• Antiseptic Action: amylmetacresol has antiseptic properties, which means it can help inhibit the growth and activity of microorganisms, such as bacteria, that can cause infections or contribute to the irritation of the throat and mouth. 
• Analgesic Action: amylmetacresol may have a mild analgesic (pain-relieving) effect. This can help reduce discomfort and soreness in the throat, providing temporary relief. 

Spectrum: 

amylmetacresol’s antiseptic action is primarily directed at bacteria. It is effective against a range of bacteria that may be present in the throat and mouth. However, its spectrum of activity is generally limited to common bacteria found in the upper respiratory tract and mouth. It may not be effective against viruses or fungi. 

Drug Interaction

Adverse Reaction

Frequency not defined 

Tongue soreness 

Hypersensitivity 

Black Box Warning

Black Box Warning: 

None 

Contraindication / Caution

Contraindication/Caution: 

Contraindications: 

• Known allergy 

Cautions: 

• Pregnancy  
• Breastfeeding 
• Children 
• Chronic use 
• Other medications 
• Skin conditions 
• Potential side effects 

Pregnancy / Lactation

Pregnancy consideration:  

amylmetacresol is not safe during pregnancy. 

Breastfeeding warnings:  

amylmetacresol is not safe during lactation.  

Pregnancy category: 

Category A: well-controlled and satisfactory studies show no risk to the fetus in the first or later trimester. 

<b>Category B: there was no evidence of risk to the fetus in animal studies, and there were not enough studies on pregnant women. 

Category C: there was evidence of risk of adverse effects in animal reproduction studies, and no adequate evidence in human studies must take care of potential risks in pregnant women.    

Category D: adequate data with sufficient evidence of human fetal risk from various platforms, but despite the potential risk, and used only in emergency cases for potential benefits.    

Category X: Drugs listed in this category outweigh the risks over benefits. Hence these categories of drugs need to be avoided by pregnant women.    

Category N: No data is available for the drug under this category. 

Pharmacology

Pharmacology:  

amylmetacresol is an antiseptic agent commonly used in throat lozenges and cough drops to help relieve sore throat and cough symptoms. It works locally in the throat and mouth, providing antiseptic and soothing effects.Top of Form  

Pharmacodynamics:  

The pharmacodynamics of amylmetacresol primarily involve its antimicrobial effects. It is thought to work by disrupting the cell membranes of bacteria, leading to leakage of cellular contents and, ultimately, bacterial cell death. This action makes it effective against various bacteria commonly associated with oral infections and sore throats. 

Pharmacokinetics: 

Absorption 

amylmetacresol is commonly used in oral hygiene products like throat lozenges and mouthwashes. When used in these forms, it is likely absorbed through the mouth and throat mucous membranes. The rate and extent of absorption can depend on various factors, including the specific formulation, concentration, and individual differences in metabolism. 

Distribution 

After absorption, the compound could be distributed through the bloodstream to various tissues. However, since amylmetacresol is often used locally in the mouth and throat, significant systemic distribution might be a minor consideration.  

Metabolism 

Metabolism could occur in the liver or other tissues, converting the compound into metabolites eliminated from the body. 

Elimination and Excretion 

If amylmetacresol were formed, metabolites would likely be excreted through urine and feces. The specifics of excretion would depend on the nature of the metabolites and the individual’s physiological processes. 

Adminstartion

Administration: 

• Throat Lozenges: amylmetacresol is often included in throat lozenges designed to relieve sore throat and minor mouth and throat infections. These lozenges typically dissolve slowly in the mouth, allowing the active compounds to contact the affected areas. The lozenges are held in the mouth and allowed to dissolve gradually, releasing the active ingredients and providing local antiseptic effects. 
• Mouthwashes and Sprays: amylmetacresol can also be found in mouthwashes and throat sprays. These products are used by rinsing the mouth or throat with the solution or spraying it onto the affected areas. This allows the active ingredients to come into contact with a broader area of the mouth and throat, providing antiseptic effects. 

Patient Information Leaflet

Patient information leaflet 

Generic Name: amylmetacresol 

Pronounced as: am-o-rol-fin 

Why do we use amylmetacresol? 

• Antiseptic Action: amylmetacresol has antimicrobial properties that help inhibit the growth and activity of various microorganisms, including bacteria. It can be effective against bacteria commonly found in the mouth and throat, making it helpful in treating minor infections and maintaining oral hygiene. 
• Sore Throat Relief: Throat lozenges containing amylmetacresol often relieve sore throat discomfort. The antiseptic properties of amylmetacresol can help reduce bacterial activity in the throat, which might contribute to soothing soreness and irritation. 
• Mouth and Throat Infections: Products containing amylmetacresol help prevent or treat minor mouth and throat infections. These infections can include pharyngitis, tonsillitis, and other bacterial infections that can cause discomfort and inflammation. 
• Oral Hygiene: amylmetacresol’s antiseptic properties make it helpful in maintaining oral hygiene. Mouthwashes or sprays containing amylmetacresol can be used in daily oral care routines to reduce bacterial growth contributing to bad breath and dental plaque. 
• Local Application: amylmetacresol is often administered in local forms, such as throat lozenges and mouthwashes. This lets the active compound directly target the affected area, providing quick and focused antiseptic effects. 
• Combined Formulations: amylmetacresol is frequently combined with other antiseptic agents like dichlorobenzyl alcohol. Combining these ingredients can enhance the overall antiseptic efficacy and broaden the spectrum of microorganisms targeted.