amylmetacresol/dextromethorphan hydrobromide

Action and Spectrum

Actions and Spectrum 

amymetacresol is an antiseptic and mild local anesthetic. It is often used in throat lozenges or sprays to help alleviate throat discomfort and irritation due to sore throat. Its primary action is to reduce the sensation of pain and irritation in the throat. 

dextromethorphan hydrobromide is a cough suppressant, which means it helps to reduce the urge to cough. It works by affecting the cough reflex in the brain. Its acts on the central nervous system to inhibit the cough reflex, providing relief from dry and irritating coughs.

Drug Interaction

Adverse Reaction

Frequency not defined  

Joint pain 

Stomachache  

Headache 

Confusion 

Facial swelling 

Tachycardia 

Moderate 

Rash 

Difficulty breathing 

Nervousness 

Drowsiness 

Hallucinations 

Mild 

Nausea or vomiting 

Dizziness 

Restlessness 

Black Box Warning

Black Box Warning 

None 

Contraindication / Caution

Contraindication/Caution: 

Contraindication: 

• Individuals who are known to be hypersensitive or allergic to amylmetacresol/dextromethorphan hydrobromide, or any other components of the medication should avoid its use. 

Caution: 

• Individuals with chronic respiratory conditions such as asthma, chronic obstructive pulmonary disease (COPD) should use dextromethorphan-containing medications with caution.  
• dextromethorphan should not be taken by individuals who are currently taking or have recently taken MAO inhibitors. 

Pregnancy / Lactation

Pregnancy consideration: 

Pregnancy category: N/A 

Lactation: Excretion into human milk is unknown  

Pregnancy Categories:         

Category A: well-controlled and Satisfactory studies show no risk to the fetus in the first or later trimester. 

Category B: there was no evidence of risk to the fetus in animal studies, and there were not enough studies on pregnant women.  

Category C: there was evidence of risk of adverse effects in animal reproduction studies, and no adequate evidence in human studies must take care of potential risks in pregnant women. 

Category D: adequate data with sufficient evidence of human fetal risk from various platforms, but despite the potential risk, and used only in emergency cases for potential benefits. 

Category X: Drugs listed in this category outweigh the risks over benefits. Hence these categories of drugs need to be avoided by pregnant women. 

Category N: There is no data available for the drug under this category. 

Pharmacology

Pharmacology  

amylmetacresol has antiseptic properties, which means it helps inhibit the growth of microorganisms such as bacteria and fungi.  

dextromethorphan hydrobromide acts on the central nervous system i.e., the cough center in the brain, to reduce the urge to cough. 

Pharmacodynamics 

Limited information available  

Pharmacokinetics 

Limited information available on ADME  

Adminstartion

Administration 

amylmetacresol and dextromethorphan hydrobromide combination drug is administered orally.  

It is available in lozenges and capsules form. 

Patient Information Leaflet

Patient information leaflet 

Generic Name: amylmetacresol/ dextromethorphan hydrobromide  

Why do we use amylmetacresol/ dextromethorphan hydrobromide? 

amylmetacresol and dextromethorphan hydrobromide combination drug are commonly used in relief from symptoms associated with respiratory infections, such as sore throat and dry cough.   

amylmetacresol is help in a sore throat and reduce discomfort by numbing the irritated tissues and inhibiting the growth of bacteria and fungi. dextromethorphan is a cough suppressant that acts on the central nervous system to reduce the urge to cough.