Anecortave acetate 

Action and Spectrum

Actions and Spectrum: 

Anti-Angiogenic:
Anecortave acetate has the major function of being an antiangiogenic drug. It prevents the formation of new blood vessels by a mechanism called angiogenesis. It becomes particularly important when the structures for vision have specific diseases; irregular blood vessels interfere with vision as they are formed. Angiogenesis is prevented by the anti-angiogenetic activity, thereby not allowing formation of new or growth of already existing weak blood vessels in the eye which cause vision loss.
Spectrum:
Age-Related Macular Degeneration (AMD): Anecortave acetate has been explored for the management of some forms of AMD most notably the neovascular or the wet form. Its main use is the inhibition of pathologic formation of new blood vessels in the retina, a condition that may cause blindness.
Diabetic Retinopathy: Diabetic retinopathy is a condition that affects the retina and hence the vision because the blood vessels that support the retina may become damaged and the disease’s nature and possibly related to anecortave acetate’s capacity for anti-angiogenic and anti-inflammatory benefits. 

Drug Interaction

Adverse Reaction

Frequency not defined   

None 

Black Box Warning

Black Box Warning:  

None   

Contraindication / Caution

Contraindication/Caution:   

Hypersensitivity 

Active Ocular Infections 

Pregnancy and Lactation 

Pregnancy / Lactation

Pregnancy/Lactation:  

Pregnancy warnings:   

Pregnancy category: N/A  

Lactation: Excreted into human milk is unknown  

Pregnancy Categories:   

• Category A: Studies that were well-controlled and met expectations revealed no risk to the fetus in either the first or second trimester.  
• Category B: There were a lack of studies on pregnant women and no evidence of risk to the fetus in animal experiments.   
• Category C: there was evidence of risk of adverse effects in animal reproduction studies, and no adequate evidence in human studies must take care of potential risks in pregnant women.   
• Category D: adequate data with sufficient evidence of human fetal risk from various platforms, but despite the potential risk, and used only in emergency cases for potential benefits.   
• Category X: Drugs listed in this category outweigh the risks over benefits. Hence these categories of drugs need to be avoided by pregnant women.   
• Category N: There is no data available for the drug under this category. 

Pharmacology

Pharmacology:  

Anecortave acetate is been primarily studied for its potential use in the treatment of various ocular conditions, particularly age-related macular degeneration (AMD).  

Pharmacodynamics:   

Anecortave acetate is believed to function by suppressing the process of angiogenesis, which involves the formation of new blood vessels & reducing inflammation within the eye, which are crucial processes involved in certain ocular diseases.  

Pharmacokinetics:  

Limited information available 

Adminstartion

Administration:   

The exact dosing and administration frequency can differ depending on the unique patient’s circumstances and the formulation employed.  

Patient Information Leaflet

Patient information leaflet  

Generic Name: anecortave acetate  

Why do we use anecortave acetate?   

Anecortave acetate has been considered for its uses in treating exudative AMD, a disease that characterised by the occurrence of abnormally formed, leaky vessels within the retina.
Anecortave acetate also has an anti-inflammatory effect, therefore, it can be applicable in the eye inflammation whereby inflammation is cause of vision complications.