anileridine phosphate

Action and Spectrum

Actions and Spectrum 

anileridine phosphate binds to opioid receptors in the brain and spinal cord. These receptors are part of the body’s natural pain control system. By binding to these receptors, anileridine phosphate reduces the transmission of pain signals and alters the perception of pain.

Drug Interaction

Adverse Reaction

Frequency not defined  

Dizziness 

Restlessness  

Nervousness  

Dry mouth 

Visual difficulty 

Perspiration 

Euphoria 

Feeling of warmth 

Itching 

Black Box Warning

Black Box Warning 

None

Contraindication / Caution

Contraindication/Caution: 

Contraindication: 

• anileridine phosphate should not be used in individuals who have a known hypersensitivity or allergy to anileridine or any of its components. 
• anileridine phosphate with monoamine oxidase inhibitors (MAOIs) or within 14 days of stopping MAOIs is contraindicated. 

Caution: 

• anileridine phosphate can depress respiratory function, so caution should be taken in patients with respiratory disorders. 
• anileridine phosphate should be used cautiously in individuals with head injuries. 

Pregnancy / Lactation

Pregnancy consideration: 

Pregnancy category: N/A 

Lactation: Excretion into human milk is unknown  

Pregnancy Categories:         

Category A: well-controlled and Satisfactory studies show no risk to the fetus in the first or later trimester. 

Category B: there was no evidence of risk to the fetus in animal studies, and there were not enough studies on pregnant women.  

Category C: there was evidence of risk of adverse effects in animal reproduction studies, and no adequate evidence in human studies must take care of potential risks in pregnant women. 

Category D: adequate data with sufficient evidence of human fetal risk from various platforms, but despite the potential risk, and used only in emergency cases for potential benefits. 

Category X: Drugs listed in this category outweigh the risks over benefits. Hence these categories of drugs need to be avoided by pregnant women. 

Category N: There is no data available for the drug under this category. 

Pharmacology

Pharmacology  

anileridine phosphate binds to specific receptors called opioid receptors in the brain and spinal cord. These receptors are part of the body’s natural pain control system.  

Pharmacodynamics 

anileridine phosphate acts as an agonist at various opioid receptors, with a primary affinity for the mu-opioid receptor.  

Pharmacokinetics 

Absorption   

anileridine phosphate is absorbed through the gastrointestinal tract after oral administration. 

Distribution 

anileridine phosphate is distributed throughout the body via the bloodstream.  

Metabolism 

anileridine phosphate undergoes metabolism primarily in the liver, where it is metabolized by various enzymatic pathways.  

Elimination and excretion 

anileridine phosphate is eliminated from the body mainly through the urine.

Adminstartion

Administration 

anileridine phosphate is typically administered via oral or parenteral (subcutaneous or intramuscular) routes.

Patient Information Leaflet

Patient information leaflet 

Generic Name: anileridine phosphate  

Why do we use anileridine phosphate? 

anileridine phosphate is used in management of moderate to severe pain such as angina pectoris, renal colic, biliary colic, and pain associated with extensive burns.   

anileridine phosphate may be used to manage acute pain episodes, such as pain resulting from injuries, trauma, or medical procedures.  

anileridine phosphate is used in acute congestive heart failure for rest and relief of apprehension and in oral surgery for relief of pain including that of exodontia.