Anthropometric Measurements as Predictors of Low Birth Weight Among Tanzanian Neonates: A Hospital-Based Study
November 7, 2025
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Brand Name :
Dritho-scalp, zithranol-RR, psoriatec, micanol
Synonyms :
anthralin
Class :
Keratolytic agent
Brand Name :
Dritho-scalp, zithranol-RR, psoriatec, micanol
Synonyms :
anthralin
Class :
Keratolytic agent
Dosage Forms & Strengths
Cream
0.5%
1%
1.2%
1% cream: Rub enough of the cream into the affected areas of the skin until it is fully absorbed
0.5% cream: Apply the product as directed after washing the hair, and then remove it by washing or showering the hair
Safety and efficacy not established
Refer adult dosing
may increase the photosensitizing effect when combined
may increase the photosensitizing effect when combined
may increase the photosensitizing effect when combined
may increase the photosensitizing effect when combined
Mechanism of action
The mechanism of action of anthralin is not fully understood, but it is thought to work by slowing down the production of skin cells and reducing inflammation.
Spectrum
It has a broad spectrum of activity and effectively treats various skin disorders, including psoriasis, seborrheic dermatitis, and eczema. It is a relatively safe medication with a low risk of severe side effects. However, it can cause skin irritation, redness, and itching if not used properly.
Frequency undefined:
Temporary skin discoloration
Staining of skin, hair, and fingernails
Allergic reactions on the skin
Lesion soreness
Contraindications
Sensitive skin: People with sensitive skin may experience skin irritation, redness, and itching with anthralin use
Allergic reactions: People with known allergies to anthralin or its components should not use the medication.
Open wounds: They should not be used on open or broken skin.
Pregnancy and breastfeeding: The safety of anthralin in pregnant or breastfeeding women has not been established, and it is best to avoid its use.
Children: The safety and efficacy of anthralin in children have yet to be established, and it is generally not recommended for use in this population
Caution
Skin irritation: It can cause skin irritation, redness, and itching if not used properly. People with sensitive skin may be more susceptible to these side effects.
Staining: It can stain clothing, towels, and bed sheets. It is essential to protect clothing and bedding when using this medication.
Photosensitivity: It can increase sensitivity to sunlight, making it more likely to experience sunburn. People using anthralin should take precautions to protect their skin from sun exposure.
Pregnancy and breastfeeding: The safety of anthralin in pregnant or breastfeeding women has not been established, and it is best to avoid its use
Children: The safety and efficacy of anthralin in children have not been established, and it is generally not recommended for use in this population
Pregnancy consideration: C
Lactation: Excretion of the drug in human breast milk is unknown
Pregnancy category:
Category A: well-controlled and Satisfactory studies show no risk to the fetus in the first or later trimester.
Category B: there was no evidence of risk to the fetus in animal studies, and there were not enough studies on pregnant women.
Category C: there was evidence of risk of adverse effects in animal reproduction studies, and no adequate evidence in human studies must take care of potential risks in pregnant women.
Category D: adequate data available with sufficient evidence of human fetal risk from various platforms, but despite the potential risk, and used only in emergency cases for potential benefits.
Category X: Drugs listed in this category outweigh the risks over benefits. Hence these categories of drugs need to be avoided by pregnant women.
Category N: There is no data available for the drug under this category
Pharmacology
It is thought to have antiproliferative effects on skin cells, and it is believed to inhibit DNA synthesis. This may help slow down skin cell production and reduce inflammation, which are critical factors in the development of psoriasis
In addition to its antiproliferative effects, anthralin may also have anti-inflammatory effects by inactivating epidermal 12-lipoxygenase and reducing endothelial cell adhesion molecule levels, which are elevated in people with psoriasis
Pharmacodynamics
When applied to the skin, anthralin is absorbed into the skin and is converted to its active form, anthraquinone. This active form is thought to interfere with the function of skin cells, leading to a reduction in the production of skin cells and a reduction in inflammation.
The antiproliferative and anti-inflammatory effects of anthralin are thought to be responsible for its therapeutic effects in treating psoriasis and other skin disorders
Pharmacokinetics
Absorption:
It is a topical medication applied to the skin and absorbed into the skin. It is not absorbed into the bloodstream significantly and does not have systemic effects
Distribution: 
Once absorbed into the skin, the skin rapidly metabolizes anthralin and is not distributed to other parts of the body
Metabolism: 
It is converted to its active form, anthraquinone after it is absorbed into the skin. This active form is thought to interfere with the function of skin cells, leading to a reduction in the production of skin cells and a reduction in inflammation
Elimination/Excretion: 
It is rapidly metabolized by the skin and is eliminated from the body within 24 hours. It is not known to accumulate in the body and is not expected to have long-term effects
Administration
Patient information leaflet
Generic Name: anthralin
Pronounced: [ AN-thra-lin ]
Why do we use anthralin?
It is a topical medication that is used for the treatment of skin disorders, particularly psoriasis. Its antiproliferative and anti-inflammatory effects are thought to be responsible for its therapeutic effects
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