arabinoxylan

Action and Spectrum

Actions and Spectrum 

It is also known as AXs which are a type of non-starch polysaccharides that are found in the cell walls of cereal grains. These pentosans are made up of xylose and arabinose which are important for hydrating cereal flour and especially in making bread with rye and wheat. By making enzymatic changes to AXs their function can be improved which in turn affects the quality of yeast-leavened baked goods. This includes their impact on the way gluten-forming proteins come together along with foam stability and the overall shelf life of the end product. 

Drug Interaction

Adverse Reaction

Frequency not defined 

Belly pain 

Belly cramps 

Intestinal gas or GIT discomfort 

Wheezing 

Fever 

Bad cough 

Seizures 

Swelling (lips, face, throat, or tongue) 

Throwing up ( very bad) 

Bowel habits ( changes) 

Blue skin colour 

Tightness in the chest 

Hypoglycemia 

Black Box Warning

Black Box Warning 

None 

Contraindication / Caution

Contraindication/Caution: 

Contraindications 

• Hypersensitivity 

Cautions 

• Renal impairment 
• Allergic to rice bran, yeast, or mushrooms 
• Infection 
• Transplantation 
• Chemotherapy 
• Auto immune disorders  
• Hepatic impairment 
• Drug interactions (immunosuppresants, antidiabetic medications) 
• Hypoglycemia 
• DM 
• Cancer 
• Pregnancy  
• Breastfeeding 
• Surgery 

Pregnancy / Lactation

Pregnancy consideration:  

No data is available regarding the administration of the drug during pregnancy. 

Breastfeeding warnings:  

No data is available regarding the excretion of drug in breast milk. 

Pregnancy category: 

Category A: well-controlled and satisfactory studies show no risk to the fetus in the first or later trimester. 

<b>Category B: there was no evidence of risk to the fetus in animal studies, and there were not enough studies on pregnant women. 

Category C: there was evidence of risk of adverse effects in animal reproduction studies, and no adequate evidence in human studies must take care of potential risks in pregnant women.    

Category D: adequate data with sufficient evidence of human fetal risk from various platforms, but despite the potential risk, and used only in emergency cases for potential benefits.    

Category X: Drugs listed in this category outweigh the risks over benefits. Hence these categories of drugs need to be avoided by pregnant women.    

Category N: No data is available for the drug under this category. 

Pharmacology

Pharmacology 

It is a pentosan polymer found in plant cell walls made up of arabinose and xylose sugars. It has effects on intestinal viscosity and nutritional digestion and can be found in both insoluble and soluble forms. Wheat’s soluble arabinoxylans are believed to be antinutritional so commercial enzymes may be added to chicken feed to minimize these effects. It have protective metabolic effects due to their viscosity and ion exchange capability and they also serve as structural components in plant cells and retain phenolic acids by providing various health benefits. 

Pharmacodynamics: 

Arabinoxylans are important components in wheat and rye that play a key role in the quality of baked goods. They affect the texture and shelf life of baked products. They also help trap gas in dough and have a mild laxative effect when consumed from psyllium husk. The amount of arabinose attached to the molecules can also affect how soluble they are in liquid. 

Pharmacokinetics: 

ADME has limited data 

Adminstartion

Administration: 

It is included in food items or supplements and taken orally 

Patient Information Leaflet

Patient information leaflet 

Generic Name: arabinoxylan 

Pronounced: uh-rab-in-uhk-suh-lan 

Why do we use arabinoxylan? 

Whole grains like wheat and barley contain a type of fiber called arabinoxylan. This fiber is beneficial for the gut microbiota,weight management, and digestion. It is also used in gluten-free products and has potential applications in wound healing and drug delivery systems.