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Brand Name :
N/A
Synonyms :
arhalofenic acid
Class :
Anti-gout agent
Brand Name :
N/A
Synonyms :
arhalofenic acid
Class :
Anti-gout agent
Dosage forms and strengths Â
Based on patient responses in clinical trials, in vivo data suggests taking 600 mg & 800 mg orally
The suggested oral dose is 200 mg, 400 mg, or 600 mg, to be taken one time a day for sixteen weeks
Not indicatedÂ
Refer adult dosingÂ
Actions and Spectrum:Â
Action:Â
Arhalofenic acid blocks URAT1 in the kidneys, decreasing uric acid reabsorption & raising its elimination through urine, thereby decreasing blood levels in gout.Â
Frequency not definedÂ
Stomach painÂ
HeadacheÂ
Black Box Warning:Â Â
None
Contraindication/Caution:Â
Hypersensitivity or allergy: If you have a known allergy to this medication or any of its components, taking it can trigger severe allergic reactions.Â
Pregnancy and breastfeeding: Arhalofenic acid is avoided during pregnancy & breastfeeding because of the lack of sufficient data.Â
Certain medical conditions: Conditions like congestive heart failure, uncontrolled hypertension, and active tuberculosis require cautious evaluation before considering arhalofenic acid due to potential interactions with existing medications or worsening of the underlying condition.Â
Pregnancy/Lactation:Â
Pregnancy warnings:Â
Pregnancy category: N/AÂ
Lactation: Excreted into human milk is unknownÂ
Pregnancy Categories:Â
Category A: Studies that were well-controlled and met expectations revealed no risk to the fetus in either the first or second trimester.Â
Category B: There were a lack of studies on pregnant women and no evidence of risk to the fetus in animal experiments.Â
Category C: There was evidence of risk of adverse effects in animal reproduction studies, and no adequate evidence in human studies must take care of potential risks in pregnant women.Â
Category D: Adequate data with sufficient evidence of human fetal risk from various platforms, but despite the potential risk, and used only in emergency cases for potential benefits.Â
Category X: Drugs listed in this category outweigh the risks over benefits. Hence these categories ofdrugsneed to be avoided by pregnant women.Â
Category N: There is no data available for the drug under this categoryÂ
Pharmacology:Â
Arhalofenic acid shows potential as a gout treatment.Â
Pharmacodynamics:Â
Arhalofenic acid blocks URAT1 in the kidneys, decreasing uric acid reabsorption & raising its elimination through urine, thereby decreasing blood levels in gout.Â
Pharmacokinetics:Â
AbsorptionÂ
Arhalofenic acid shows rapid absorption in the bloodstream.Â
DistributionÂ
Arhalofenic acid is distributed throughout the body.Â
MetabolismÂ
The drug metabolism occurs in liver.Â
Excretion and EliminationÂ
The drug excretion occurs in feces by process of biliary excretion & elimination occurs through urine.Â
Administration:Â
The drug is taken orally.Â
Patient information leafletÂ
Generic Name: arhalofenic acidÂ
Why do we use arhalofenic acid?Â
Arhalofenic acid is useful for reducing inflammation & joint pain & preventing gout attacks.Â
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