artesunate

Action and Spectrum

Drug Interaction

Adverse Reaction

Adverse drug reactions  

Frequency Defined  

>10%  

Thrombocytopenia (18%)  

Hyperbilirubinemia (14%)  

Anemia (65%)  

Increased transaminase (27%)  

1-10%  

Pneumonia (3%)  

Pulmonary edema (3%)  

Leukocytosis (10%)  

ARDS (8%)  

Lymphopenia (7%)  

Neutropenia (5%)  

Diarrhea (3%)  

DIC (3%)  

Elevated creatinine (3%)  

Neurologic sequelae (1%)  

Jaundice (2.3%)  

Hemoglobinuria (6.7%)  

Black Box Warning

Contraindication / Caution

Pregnancy / Lactation

Pregnancy warnings:     

US FDA pregnancy category: Not Assigned 

Lactation: 

Excreted into human milk is known 

Pregnancy Categories:       

Category A: Satisfactory and well-controlled studies show no risk to the fetus in the first or later trimester.       

Category B: No evidence shown of risk to the fetus found in animal reproduction studies, and there are not enough studies on pregnant women       

Category C: Adverse effects on the fetus found with evidence in animal reproduction studies and no adequate evidence for a result in humans must take care of potential risks in pregnant women       

Category D: adequate data available with sufficient evidence of human fetal risk from various platforms, but despite the potential risk, and used only in emergency cases for potential benefits.       

Category X: Drugs listed in this category outweigh the risks over benefits. Hence these categories of drugs need to be avoided by pregnant women.       

Category N: There is no data available for the drug under this category 

Pharmacology

Adminstartion

Patient Information Leaflet

Patient Information Leaflet    

Generic Name: artesunate  

Why do we use artesunate? 

artesunate is a Miscellaneous antimalarials used to treat Malaria.