articulin

Action and Spectrum

Actions and Spectrum: 

articulin is a nonsteroidal anti-inflammatory drug (NSAID) that works by inhibiting the activity of cyclooxygenase (COX) enzymes, which are responsible for the production of prostaglandins. Prostaglandins are hormone-like substances that are involved in the inflammatory response, and their inhibition by articulin leads to a reduction in inflammation, pain, and fever. 

In terms of spectrum, articulin is effective against a wide range of conditions that involve inflammation, pain, and fever, including osteoarthritis, rheumatoid arthritis, ankylosing spondylitis, gout, menstrual cramps, and headache. It is also effective in reducing post-operative pain and inflammation. 

articulin’s spectrum of action is primarily limited to the inhibition of COX-2 enzymes, which are involved in the production of prostaglandins at sites of inflammation. By selectively inhibiting COX-2 enzymes, articulin provides effective pain relief while minimizing the risk of gastrointestinal side effects, which are often associated with the inhibition of COX-1 enzymes. 

Drug Interaction

Adverse Reaction

Frequency not defined  

Abdominal pain 

Dermatitis 

Nausea 

Black Box Warning

Black Box Warning:   

articulin carries a black box warning regarding the risk of serious cardiovascular events, gastrointestinal bleeding, ulceration, and perforation, as well as potential liver and kidney toxicity, hypersensitivity reactions, and hematological abnormalities. Healthcare providers should carefully evaluate each patient’s individual risk factors and weigh the potential benefits of treatment against the potential risks before prescribing articulin. 

Due to the serious risks associated with articulin, it is important to carefully evaluate each patient’s individual risk factors and weigh the potential benefits of treatment against the potential risks. Patients should be advised to take articulin only as directed and to report any adverse effects to their healthcare provider immediately. 

Contraindication / Caution

Contraindication/Caution:  

articulin is contraindicated in patients with a known hypersensitivity to nonsteroidal anti-inflammatory drugs (NSAIDs), including articulin. 

 Additionally, the use of articulin is contraindicated in patients who have experienced asthma, urticaria, or other allergic-type reactions after taking aspirin or other NSAIDs. 

articulin is also contraindicated in patients who have a history of gastrointestinal bleeding or perforation, which may be exacerbated by the use of NSAIDs.  

In addition, patients with a history of peptic ulcer disease, inflammatory bowel disease, or other gastrointestinal disorders should use articulin with caution. 

Patients who are currently taking anticoagulant therapy or who have a bleeding disorder should also exercise caution when using articulin, as the medication may increase the risk of bleeding. 

Pregnancy / Lactation

Pregnancy warnings:     

Pregnancy category: N/A 

Lactation: Excreted into human milk is unknown 

Pregnancy Categories:         

Category A: Studies that were well-controlled and met expectations revealed no risk to the fetus in either the first or second trimester. 

Category B: There were a lack of studies on pregnant women and no evidence of risk to the fetus in animal experiments.   

Category C: there was evidence of risk of adverse effects in animal reproduction studies, and no adequate evidence in human studies must take care of potential risks in pregnant women.    

Category D: adequate data with sufficient evidence of human fetal risk from various platforms, but despite the potential risk, and used only in emergency cases for potential benefits.   

Category X: Drugs listed in this category outweigh the risks over benefits. Hence these categories of drugs need to be avoided by pregnant women.    

Category N: There is no data available for the drug under this category

Pharmacology

Pharmacology: 

articulin is a pharmaceutical agent that belongs to the class of nonsteroidal anti-inflammatory drugs (NSAIDs) and is commonly used to manage pain and inflammation. The active ingredient in articulin is diclofenac sodium, which acts by inhibiting the production of prostaglandins, which are responsible for mediating pain, inflammation, and fever.  

Pharmacodynamics Mechanism: 

articulin is a medication used to treat inflammatory conditions. Its pharmacodynamic mechanism involves inhibition of the enzyme cyclooxygenase (COX), which is responsible for the conversion of arachidonic acid into prostaglandins. By inhibiting COX, articulin reduces the production of prostaglandins, which are known to cause inflammation and pain. Additionally, articulin inhibits the activity of leukotrienes, which are also involved in the inflammatory response.  

Mechanism of Action:  

The mechanism of action of articulin involves inhibition of COX-2, which reduces the production of prostaglandins involved in inflammation and pain. This results in the relief of symptoms associated with arthritis. The pharmacokinetics of articulin involve rapid and complete absorption following oral administration, with a short elimination half-life. 

Pharmacokinetics: 

Absorption 

articulin is administered via injection and thus is immediately available for absorption into the bloodstream. The drug’s absorption rate is rapid and its bioavailability is high. 

Distribution 

articulin has a high volume of distribution and primarily distributes to synovial fluid in the joints. The drug does not bind extensively to plasma proteins. 

Metabolism 

 articulin is metabolized primarily in the liver via oxidation and conjugation pathways. The primary metabolic pathway is mediated by the cytochrome P450 (CYP) enzyme system, specifically CYP3A4 and CYP2C9. 

Excretion and elimination:  

articulin is primarily eliminated via the kidneys as unchanged drug, with a small amount of the drug eliminated via fecal excretion. The drug has a moderate half-life of approximately 12 hours, which may be increased in patients with impaired renal function. 

Adminstartion

Administration:  

articulin is a medication that is typically administered via injection into the affected joint. The dosage and frequency of administration will vary depending on the severity of the condition being treated and the individual patient’s medical history.  

Prior to administration, the injection site should be properly cleaned and disinfected. A healthcare professional will typically administer the injection in a clinical setting, such as a doctor’s office or hospital.  

It is important to follow the dosage and administration instructions provided by the prescribing healthcare professional, as improper administration may result in adverse effects or reduced efficacy of the medication. 

As with any medication, it is essential to discuss any concerns or questions about articulin administration with a qualified healthcare professional. 

Patient Information Leaflet

Patient information leaflet 

Generic Name: articulin 

Why do we use articulin?  

articulin is a medication that is commonly used to treat the symptoms of osteoarthritis. It belongs to the class of drugs known as nonsteroidal anti-inflammatory drugs (NSAIDs) and works by inhibiting the production of prostaglandins, which are inflammatory mediators that contribute to pain, swelling, and stiffness in joints affected by osteoarthritis.  

articulin is typically used to alleviate the pain and inflammation associated with osteoarthritis, a degenerative joint disease that affects millions of people worldwide. This condition occurs when the cartilage in joints breaks down over time, leading to pain, stiffness, and reduced range of motion. 

articulin can help to reduce these symptoms, allowing individuals with osteoarthritis to lead more active and comfortable lives.